No abstract available.
HL-60 Cells* ; Humans ; Mass Screening* ; Protein Kinases*

No abstract available in English.
Electric Stimulation

We performed a clinical study of the effect of electrical current on the congenital pseudarthrosis of the tibia from May, 1980 to January, 1984. Eight congenital pseudarthrosis were treated with direct current stimulation, six of which had received previous treatment at least more than one time in any manner and two had none. Four were failures in previous treatment with vascularized fibular graft due to the non-uoion at the proximal or distal sites of grafted bones. Six of eight congenital pseudarthrosis were treated with invasive type electrical stimulators, and the remaining two were treated with semi-invasive type. The average follow-up period was 26 months (range from 8 to 39 months). As a result satisfactory union has occured in seven out of eight cases. The mean time for union was 27 weeks (range from 15 weeks to 48 weeks). No serious complication was observed, but in our experience, the semi-invasive type, comparing to invasive type, was handicaped with minor complications such as pin tract infection and skin sloughing due to the irritation by anode pad, and needed frequent recharging to maintain adequate voltage. With above result, we think that the electrical stimulation has revealed to be one of the reliable methods in the treatment of surgery-resistant congenital pseudarthrosis.
Clinical Study ; Electric Stimulation ; Electrodes ; Follow-Up Studies ; Pseudarthrosis ; Skin ; Tibia ; Transplants

No abstract available.
Teratoma* ; Uterus*

OBJECTIVE: To investigate the prevalence and risk factors of carpal tunnel syndrome in diabetic patients. METHOD: Electrodiagnostic study was performed to diagnose carpal tunnel syndrome and polyneuropathy in 266 (male 151, female 115) diabetic patients. General charateristics, diabetes related factors, anthropometric factors were compared between non-carpal tunnel syndrome and carpal tunnel syndrome groups to identify the risk factors for carpal tunnel syndrome. RESULTS: Prevalence of carpal tunnel syndrome in diabetic patients was 16.2 % (43 subjects). Female, farming, wrist depth width ratio (>or=0.7) were associated with carpal tunnel syndrome in diabetic patients. In right hand, odds ratio was 12.82 (95% confidence interval: 2.97~55.3) in female, 5.15 (95% confidence interval: 1.17~22.7) in farming, 28.53 (95% confidence interval: 1.80~451.1) in wrist depth width ratio (>or=0.7). The similar results were also observed in left hand. CONCLUSION: The results suggest that occupation, sex, and anthropometric factor like wrist shape were more associated with carpal tunnel syndrome in diabetic patients than diabetes mellitus itself.
Carpal Tunnel Syndrome* ; Diabetes Mellitus ; Female ; Hand ; Humans ; Occupations ; Odds Ratio ; Polyneuropathies ; Prevalence* ; Risk Factors* ; Wrist

PURPOSE: The treatment of choice for gastric submucosal tumors (SMT) is surgical resection. Recent advanced techniques has facilitated more extensive application of laparoscopic surgery to most types of resectable gastric SMTs. The aim of this study was to verify the efficacy of laparoscopic resection for treatment of gastric SMT through analysis of outcomes obtained at a single center. METHODS: A total of 141 patients who underwent laparoscopic resection for treatment of gastric SMT were enrolled between April 2003 and June 2011. Analysis of the demographics, tumor characteristics, and surgical or oncological outcomes of these patients was performed. RESULTS: Gastrointestinal stromal tumors (GIST) were the most common pathologic findings (90 cases), and the upper third of the stomach was the most common location (70 cases). Wedge resections were performed in 128 patients and major gastrectomies were performed in 13 patients. The mean surgical time was 102 minutes, which was reduced to a stable 70 minutes after the 30th case. The surgical time for tumors located on the posterior or lesser portion of the upper third of the stomach was longer than that for other lesions. Twelve postoperative complications, including two cases of intra-abdominal bleeding, one case of marginal ulcer bleeding, and one case of leakage occurred. However, there was no occurrence of complications after the 70th case. During the follow-up period, two patients suffered recurrent GIST. CONCLUSION: Laparoscopic surgery for treatment of gastric SMT is safe and feasible, particularly as the surgeon develops greater skill with increased experience. Laparoscopic resection is useful for treatment of any type of gastric SMT.
Demography ; Follow-Up Studies ; Gastrectomy ; Gastrointestinal Stromal Tumors ; Hemorrhage ; Humans ; Laparoscopy ; Operative Time ; Peptic Ulcer ; Postoperative Complications ; Stomach ; Stomach Neoplasms

PURPOSE: Keloid is a clinical term characterized by elevation and extension of scar tissue beyond wound margin. Currently, there is no known treatment that shows consistent effect in all patients. Postoperative radiation therapy is known to prevent recurrence of keloid. METHODS: We reviewed data of patients who had undergone operation or operation followed by radiation therapy at our institute for the last 12 years. Follow up was possible in 39 patients(21 patients treated only by operation and 18 treated by operation and radiation therapy) We then investigated recurrence in both groups by VAS score. By mail, patients were asked to score their current condition on the bar in 4 aspects(itching, pain, mass lesion(by patients and other persons)). Two criteria were used for defining successful treatment. One is the case which total VAS score was 0, and the other is sum of VAS score of mass lesion was 0 to 5. RESULTS: In the former, recurrence rate is 90.5% in operations-only group but 66.7% in operations plus radiation therapy group(p 0.05). In the latter, recurrence rate is 66.7% in operation-only group but 22.2% in operations plus radiation therapy group(p 0.05). CONCLUSION: These results shows postoperative radiation therapy is effective method in keloid treatment.
Cicatrix ; Follow-Up Studies ; Humans ; Keloid* ; Postal Service ; Recurrence ; Retrospective Studies* ; Wounds and Injuries

No abstract available.
46, XY Disorders of Sex Development* ; Humans ; Male*

PURPOSE: To evaluate the efficacy of combined treatment of surgery and chemoradiotherapy for supratentorial primitive neuroectodermal tumors (SPNET) and obtain the prognostic factors and complications. MATERIAL AND METHODS:The age of 18 patients ranged from 1 to 27 years (median=5 years). There were 12 males and 6 females. The extents of surgery were gross total (n=9), subtotal (n=8), biopsy only (n=1). Craniospinal radiotherapy was delivered to all the patients except 2 patients who were treated only with the whole brain and primary lesion. Radiation dose were 3120-5800cGy (median=5460) to primary mass, 1500-4200cGy (median=3600cGy) to the whole brain and 1320-3600cGy (median= 2400 cGy) to the spinal axis. Chemotherapy was done in 13 patients. Median follow-up period was 45 months ranged from 1 to 89 months. RESULTS: Patterns of failure were as follows; local recurrence (1), multiple intracranial recurrence (2), spinal seeding (3), craniospinal seeding (2) and multiple bone metastasis (1). Two of two patients who did not received craniospinal radiotherapy failed at spinal area. All the relapsed cases died at 1 to 13 months after diagnosis of progression. The 2- and 5-year overall survival rates were 61% and 49%, respectively. The age, sex, tumor location did not influence the survival but aggressive resection with combined chemotherapy showed better outcome. Among 9 survivors, complications were detected as radiation necrosis (n=1), hypopituitarism (n=2), cognitive defect (n=1), memory deficit (n=1), growth retardation (n=1). CONCLUSION: To improve the results of treatment of SPNET, maximal surgical resection followed by radiation therapy and chemotherapy is necessary. The extended radiation field including craniospinal axis may reduce the recurrence in spinal axis.
Axis, Cervical Vertebra ; Biopsy ; Brain ; Chemoradiotherapy ; Diagnosis ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Hypopituitarism ; Male ; Memory Disorders ; Necrosis ; Neoplasm Metastasis ; Neuroectodermal Tumors, Primitive* ; Radiotherapy* ; Recurrence ; Survival Rate ; Survivors

This study reports the protective of systemic nicardipine and intracisternal nicardipine administration in the three-hemorrhage canine model of chronic cerebral vasospasm. Twenty-one dogs were assigned to one of three groups : control, intravenous nicardipine, and intracisternal nicardipine. All animals received a total of 12ml of fresh unheparinized autologous blood via three cisternal injection. Selective vertebral angiograms were obtained before intravenous nicardipine for 7 days continuously, the other seven were treated by intracisternal nicardipine for 7 days, and the remaining were not treated. Animals were sacrificed at day 9. Comparisons were based on the percentage of reduction in basilar artery diameter(% RBAD). The ultrastructural changes were studied by transmission electron microscopy(TEM). There was a mean reduction(+/- standard deviation) of 54+/-6% in control dogs, 35+/-4% in dogs with intravenous nicardipine, 32+/-6% in dogs with intracisternal dicardipine(difference significant, t-test, P<0.05). The preventive effects of intracisternal nicardipine was superior to those of intravenous nicardipine. There was a strong trend toward reduction of medial necrosis in the basilar artery in dogs with intravenous and intracisternal group compared to control dogs. All basilar arteries showed structural changes with celectron microscopic examination ; these included medial necrosis, lysosome, initial changes, endothelial cell vacuoles, and adventitial erythrocytes, leukocytes. Intimal proliferation was unusual in all three groups, but reduction of intimal proliferation was found in dogs with treatment, and it was believed that vasospasm in this stage is due to long-standing smooth muscle contraction and not to arterial wall thickening. There was significant reduction of blood clot in intracisternal nicardipine group, which may be due to inhibitory action on platelet aggregation of nicardipine. These investigations support the hypothesis that the presence of clotted blood around the intracranial arteries is the cause of vasospasm.
Animals ; Arteries ; Basilar Artery ; Dogs ; Endothelial Cells ; Erythrocytes ; Leukocytes ; Lysosomes ; Muscle, Smooth ; Necrosis ; Nicardipine* ; Platelet Aggregation ; Vacuoles ; Vasospasm, Intracranial*