This article analysis the present situation of less than 35 years of Sun Yat-sen university youth scientific and technological personnel,they declare、undertake to support basic research based science fundation related cases,discusses the science foundation for their assistance and training problems,put forward youth scientific talents to suit the science funds development requirements to promote their development proposals

OBJECTIVE:To compare the effects of2different treatment methods on the assaying of triptolide alcohol in tripterygium wilfordii cut crude drug.METHODS:After concentration,tripterygium wilfordii cut crude drug water decoction underwent column chromatographic separation after adsorption with neutral alumina(Method1)and neutral alumina column chromatographic separation after ethanol precipitation and extraction by chloroform(Method2),respectively.Triptolide alcohol was determined by HPLC and the assaying result underwent pairing and t tests.RESULTS:There was significant difference between the2methods with the content determined by Method1significantly higher than that by Method2(P

Although alpha2-adrenoceptor agonists are widely used as postoperative sedatives in adults, the postoperative effects in pediatric patients with secondary pulmonary arterial hypertension (PAH) due to congenital heart disease are not well known. We experienced a case of successful ventilator weaning with continuous intravenous administration of dexmedetomidine (DEX) after surgical correction in a 46-month-old child with congenital ventricular septal defect (VSD) with severe PAH. She underwent VSD closure on cardiopulmonary bypass (CPB). After successful weaning from the CPB, hemodynamics and oxygenation were stabilized on DEX and nitroglycerin in the intensive care unit. The patient was successfully weaned from the ventilator 46 hours after surgery. The transthoracic echocardiogram two weeks after surgery showed a closed VSD with no residual shunt and trivial tricuspid regurgitation (Vmax = 2.5 m/sec) without PAH.
Administration, Intravenous ; Adult ; Cardiopulmonary Bypass ; Child* ; Child, Preschool ; Dexmedetomidine* ; Heart Defects, Congenital ; Heart Septal Defects, Ventricular* ; Hemodynamics ; Humans ; Hypertension* ; Hypnotics and Sedatives ; Intensive Care Units ; Nitroglycerin ; Oxygen ; Tricuspid Valve Insufficiency ; Ventilator Weaning ; Ventilators, Mechanical ; Weaning

An experiment on seminal vesiculitis in rats induced by repeated injections of homologous and heterologous seminal vesicle tissue suspension with Freund's complete adjuvant was accomplished to produce an immune disease in the seminal vesicle for the purpose to find the cause of same type of lesion in human beings were divided into 7 In this study 65 healthy adult white rats which weighed from 150 to 250 gm. were divided into 7 groups are follows: Group 1. Six rats, control, injected with normal saline Group 2. Six rats, injected with adjuvant Group 3. Seven rats, injected with seminal vesicle tissue suspension Group 4. Six rats, injected with rat seminal vesicle tissue suspension and adjuvant with prednisolone Group 5. Seven rats, injected with rabbit seminal vesicle tissue suspension Group 6. Seven rats, injected with rabbit seminal vesicle tissue suspension with adjuvant. Rats in these 6 groups were injected weekly for 8 weeks and sacrificed on the sixty fourth day. Group 7. Twenty-six rate, rat seminal vesicle tissue suspension with adjuvant. Rats in this group were subdivided into four groups Group A. Five rats, injected 4 times and sacrificed on 64th day. Group B. Seven rats, injected 6 times and sacrificed on 64th day. Group C. Seven rats, injected 8 times and sacrificed on 64th day. Group D. Seven rats. injected 8 times and sacrificed on 92nd day. Seminal vesicles from all the rats sacrificed were histopathologically studied and results were obtained as follows. Significant histopathologic alterations suck as glandular atrophy, decreased secretoryactivity, interstitial fibrosis, edema. congestion and inflammatory cellinfiltration suggesting of noninfectious chronic seminal vesiculitis were obtained in most rats of Group 7. Severity of inflammatory reaction seemed to be accentuated according to the increase of frequency of the date of sacrifice not concerned. Those allergic reaction were appeared to be inhibited by administration of prednisolone.
Adult ; Animals ; Atrophy ; Edema ; Estrogens, Conjugated (USP) ; Fibrosis ; Humans ; Hypersensitivity ; Immune System Diseases ; Prednisolone ; Rats ; Seminal Vesicles*

Alteration of H-and M-isozymfs of Lactic Dehydrogenase(LDH) were observed in the various tissues after exposing the rats to 50ppm and 250ppm of sulfur dioxide. These isozymes of the respective tissue were separated by Diethlaminoethyl(DEAE)-cellulose from tile tissue homogenates of brain, lung and muscle, presenting the activities by rate of reduction of nicot inamids-adenine-dinucleotide (NAD+). Pure LDH and the coenzyme NAD (NAD) were directly treated with sulfur dioxide in vitro order to find out the direct to sulfur dioxide on LDH and NAD+ and the results were as follow. 1. In the normal tissues, the H-isozyme activity was dominant in the brain and heart, and tole M-isozyme in the muscle. 2. In the lung tissue of normal rats, there was no different between tole activity of H-and M-type of LDH. 3 When rats inhale sulfur dioxide gas in concentration of 50ppm and 230ppm, it appeared that the H-type tend to be suppressed in aerobic tissues and the M-type in anaerobic tissues. 4. In the lung tissue exposed to sulfur dioxide, both the LDH activities were suppressed. 5. It seems that LDH and the coenzyme (NAD ) are not directly affected by exposing in sulfur dioxide gas.
Animals ; Brain ; Heart ; Isoenzymes ; Lung ; NAD ; Rats ; Sulfur Dioxide* ; Sulfur*

[Objective] To study Yi Pian of Su Wenand its author. [Method] Using the method of documents index and collection and research to make comprehensive texual research onYi Pian of Su Wento prove the origin from the aspect of term and verb and rhetoric and so on. [Result]Yi Pian of Su Wenis the work after Tang Dynasty,quoting fromXuan Zhu Mi Yu.The rhetoric of it is not the usage before Han Dynasty,for example,black corps,green corps,red corps and so on.We can see the usage of Jia Ling in the work,which was begun fromShang Han Za Bing Lunrather than Nei Jing.The understanding of Yun Qi theory inherited from the theory of Wang Bing.Many therapeutic methods were created by LIU Wenshu instead of WANG Bing orNei Jing. LIU Wenshu wroteSu Wen Ru Shi Yun Qi Lun Aowhich was based on seven sheets of Yun Qi and the theory of WANG Bing,possessing the theory basis ofYi Pian of Su Wen.[Conclusion] Thus we regarded theYi Pian of Su Wenas the work of LIU Wenshu who had made a great contribution to the theory of Five Yun and Six Qi.Su Wen Ru Shi Yun Qi Lun Aoclarified the truth of Yun Qi by plotting,creating Gan Zhi Qi Yun and Si Tian Jue. LIU Wenshu made the theory of Tian Di Jia Zi ,which was founded inXuan Zhu Mi Yu,as the theoretical foundation of'transformation of plague in three years'.He developed the theory and put forward the treatment method.

To find out whether articles that recommended by F1000 medical edition really contain more valuable information than others.Thirty articles published in NEJM were selected from F1000 medical edition (Group A).For each article that entered our collection,another article was picked out from the same issue as control (Group B).ISI Web Service was usedto gain the cited times of these selected articles.The results were statisticallyanalyzed with paired t test.Total cited times were range from 54 to 1 256 in group A versus 20～614 in group B,with 345.2 versus 198.6 in meantimes.Meancited times of first three years was 144.2 in group A versus 88.9 in group B and 210 versus 109.8 in the years that follows.Cited times of articles in group A was higher than that of group B significantly (P=0.05,t=2.430 9).F1000 articles contain more valuable information than others and can act as an important role in acquiring high quality medical information.As F1000 does not contain all high quality information in medical field,other tools are needed if onewants to get all of the concerning information.

Our objective is to enable the blind to use smartphones with touchscreens to make calls and to send text messages (sms) with ease, speed, and accuracy. We believe that with our proposed platform, which enables the blind to locate the position of the keypads, new games and education, and safety applications will be increasingly developed for the blind. This innovative idea can also be implemented on tablets for the blind, allowing them to use information websites such as Wikipedia and newspaper portals.
Visually Impaired Persons ; Cell Phones ; Inventions

Objective To evaluate the efficacy and safety of mini-incision transthoracic occlusion for patent ductus arteriosus(PDA)in adults.Methods From November 2005 to May 2007,10 adult patients(occlusion group)received mini-incision transthoracic occlusion of PDA under the guidance of transesophageal ultrasonography in our hospital.A 3-to 5-cm incision was made at the second intercostal space adjacent to the left sternum to expose the pulmonary aorta.Afterwards,a catheter was introduced into the pulnonary artery,and then delivered into the aorta via the PDA under the guidance of ultrosonograohpy.An occluder of 4 to 6 mm larger than the PDA in diameter was then released to engage on the defect.Twenty patients who recieved on-pump surgery were set as a control group.Results Compared with the control,patients in the occlusion group had a smaller incision [(3.6?1.6)cm vs(25.3?5.4)cm,t'=-16.575,P

Objective:To summarize the experience in nursing diaphragmatic laceration patients after traumatic rupture. Methods:A retrospective analysis was performed for 28 patients admitted to our department between 1995 and 2007,the treatment,nursing care and complications were reviewed and summarized. Results:All the patients recovered uneventfully and no complications occurred. Conclusion:Early diagnosis,active treatment and meticulous nursing care play a key role in the successful treatment of patients with traumatic diaphragmatic rupture.