This article analysis the present situation of less than 35 years of Sun Yat-sen university youth scientific and technological personnel,they declare、undertake to support basic research based science fundation related cases,discusses the science foundation for their assistance and training problems,put forward youth scientific talents to suit the science funds development requirements to promote their development proposals

OBJECTIVE:To compare the effects of2different treatment methods on the assaying of triptolide alcohol in tripterygium wilfordii cut crude drug.METHODS:After concentration,tripterygium wilfordii cut crude drug water decoction underwent column chromatographic separation after adsorption with neutral alumina(Method1)and neutral alumina column chromatographic separation after ethanol precipitation and extraction by chloroform(Method2),respectively.Triptolide alcohol was determined by HPLC and the assaying result underwent pairing and t tests.RESULTS:There was significant difference between the2methods with the content determined by Method1significantly higher than that by Method2(P

Lysosomal storage disorders (LSDs) are genetic defects caused by lysosomal hydrolase deficiencies. These deficiencies lead to substrate accumulation affecting cells, tissues and organs. Detecting abnormal compound excretion and deficient enzymes assist diagnosis of these disorders for treatment and prevention. This mini review summarizes clinical presentations and diagnostic workup of LSDs and updates the new development in the area.

Objective To investigate the feasibility of bedside temporary transvenous cardiac pacing with balloon tipped floating catheter under non X-ray fluoroscopy.Methods Twenty-four patients of bedside temporary transvenous cardiac pacing,11 cases underwent common electrode (common group),13cases underwent balloon tipped floating electrode (balloon tipped group).The operating time,pacing thresholds,pacing perception and complications were observed between two groups.Results All balloon tipped group placement success,8 cases in common group successfully.The operating time in balloon tipped group was significantly less than that in common group [(2.5 ± 1.5) min vs.(9.3 ±5.3) min],there was significant difference (P ＜ 0.05),but pacing thresholds and pacing perception between two groups had no significant difference (P ＞ 0.05).Common group occurred complications in 2 cases,respectively cardiac perforation and induced paroxysmal ventricular tachycardia,balloon tipped group occurred concurrent electrode wire dislocation in 2 cases.Conclusion Compared with the common electrode,balloon tipped floating electrode is simple,fast,high success rate and low risk of complications,suitable emergency physician bedside operating emergency temporary pacing.

Objective: To observe the clinical effects of Mudan granules in the treatment of granule with diabetic peripheral neu-ropathy. Methods:Totally 60 cases of diabetic peripheral neuropathy were randomly divided into the control group (30 cases) and the study group (30 cases) both with hypoglycemic treatment. The control group was receivedα-lipoic acid tablets, while the study group was treated with Mudan granules. The treatment course was 8 weeks. FBG, 2hPG and hemorheology indices were determined and com-pared. Results:After the treatment in the study group, the plasma viscosity, whole blood viscosity, hematocrit and content of fibrino-gen were improved, and there were significant differences between the two groups (P<0. 05). Conclusion:Mudan granules are suit-able for the treatment of diabetic peripheral neuropathy.

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily. Due to its almost ubiquitous expression, GR plays an important role in many physiological and pathological processes. These include regulation of homeostasis, adaptation to stress, and modulation of central nervous system. In addition, GR is a major modulator of the immune system due to its proficient anti-inflammatory and immunosuppressive activity; and its function is important for proper regulation of many physiological processes. The exploration on the regulation of traditional Chinese medicine on GR has established a modern physiological and pathological foundation for research of traditional Chinese medicine.

Objective To explore the clinical efficacy of percutaneous vertebroplasty technique(PVP) in the patients with senile osteoporotic thoracolumbar compression fractures (OVCFs) and to explore the main factors of PVP.Methods PVP treatment of OVCFs 46 cases,in the perspective of C-arm X-ray,bone cement as a filling material,transpedicular puncture and injection of 59 vertebrae.Results The pain in 35 cases(76.09％) OVCFs patients apparent ease or disappear,the remaining 11 cases of moderate relief;follow-up period(3 to 15)months(mean 8.6months).After X-ray review,the patient' s bone cement dispersion was good and has improved vertebral height has not been lost,activity and quality of life significantly inproved.Conclusion PVP is simple,less invasive,etc.,which can quickly reduce pain and improve their quality of life.

Objective To investigate the effect of atorvastatin and fluvastatin in unstable angina patients after intervention on matrix metalloproteinase-9 (MMP-9) and interleukin-18 (IL-18).Methods One hundred and four patients with unstable angina were divided into atorvastatin group and fluvastatin grourp with 52 cases each by random digits table.Atorvastatin group was given atorvastatin 10 mg/d,and fluvastatin group was given fluvastatin 40 mg/d for 6 weeks on the basis of conventional treatment.The change of blood fat,MMP-9 and IL-18 was observed in two groups.Results There was no significant difference in MMP-9 and IL-18 on admission,1 d before operation and 1 d or 6 weeks after operation between atorvastatin group and fluvastatin group (P ＞ 0.05).The level of MMP-9,IL-18 1 d after operation in atorvastatin group and fluvastatin group was higher than that on admission,1 d before operation [(328.47 +49.15) μg/L vs.(237.10 + 57.32),(235.97 + 56.24) μ g/L,(218.75 + 38.00) ng/L vs.(120.42 + 25.50),(115.22 + 28.93)ng/L and (330.42 ± 50.04) μ g/L vs.(235.98 ± 60.36),(236.29 ± 53.02) μ g/L,(220.16 ± 37.12) ng/L vs.(119.43 ± 24.85),(117.14 ± 26.80) ng/L] (P ＜ 0.05).The level of MMP-9,IL-18 6 weeks after operation was decreased in atorvastatin group and fluvastatin group [(152.28 ± 43.20) μ g/L,(101.36 ± 23.67) ng/L and (150.30 ± 44.18) μ g/L,(100.45 ± 24.58) ng/L],which had significant difference compared with that on admission,1 d before and after operation(P ＜ 0.05).There was no significant difference in triacylglycerol (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) on admission,1 d before and after operation between atorvastatin group and fluvastatin group (P ＞ 0.05).There was significant difference in TG,TC,HDL-C,LDL-C 6 weeks after operation between atorvastatin group and fluvastatin group [(2.05 ± 1.00),(5.15 ±0.61),(1.84 ±0.50),(3.13 ±0.88) mmol/L and (1.87 ± 1.05),(5.52 ± 0.84),(2.82 ± 0.57),(2.61 ± 0.79) mmol/L] (P ＜ 0.05).There was no significant difference in TG,TC,HDL-C,LDL-C 1 d after operation compared with that on admission,1 d before operation (P ＞ 0.05).There was significant difference in TG,TC,HDL-C,LDL-C 6 weeks after operation compared with that on admission,1 d before and after operation in atorvastatin group and fluvastatin group (P ＜0.05).Conclusions In unstable angina patients after intervention,MMP-9,IL-18 can significantly increase.Atorvastatin or fluvastatin therapy can obviously reduce the MMP-9,IL-18 and lipid level,but fluvastatin shows better effect.

Objective To observe the effect of levocamitine on cardiac function of patients with dilated cardiomyopathy (DCM).Methods 40 patients with DCM were randomly divided into control group (n =20) and the experimental group(20 cases).Control group was given conventional drug such as digitalis,furosemide,benazepril hydrochloride,antisterone for treatment,the experimental group was given levocarnitine on the basis of control group.The treatment efficacy and the situation of cardiac function were compared between the two groups.Results The total effective rate was 95.0％ and 80.0％ in the experimental group and the control group,respectively,the difference was statistically significant(x2 =10.286,P ＜ 0.01).Compared with the control group,the parameters of stroke volume,cardiac output,ejection fraction,and left ventricular fractional shortening rate were significantly increased in the experimental group after treatment(all P ＜ 0.05).Conclusion Levocarnitine can improve cardiac function based on the conventional treatment.

Objective To investigate the diagnostic value of volume imaging for breast assessment (VIBRANT) dynamic enhanced MR for benign and malignant breast mass.Methods Ninety-eight patients with breast mass underwent both bilateral molybdenum target radiography and VIBRANT dynamic enhanced MR examination.The sensitivity,specificity,positive predictive value,negative predictive value and diagnosis accuracy between two methods were compared.Results There were 113 lesions including 65 lesions in 57 malignant cases and 48 lesions in 41 benign cases.The sensitivity,specificity,positive predictive value and negative predictive value of molybdenum target radiography were 67.69％ (44/65),68.75％ (33/48),74.58％ (44/59) and 61.11％ (33/54),respectively.The values of VIBRANT dynamic enhanced MR were 84.62％ ( 55/65 ),89.58％ (43/48),91.67％ (55/60) and 81.13％ (43/53),respectively.The difference of the diagnosis accuracy between two methods had statistical significance (P ＜0.05).Conclusion The diagnostic value of VIBRANT dynamic enhanced MR for benign and malignant breast mass is higher than molybdenum target radiography.