1.A Case of Separation of the Symphysis Pubis and 2 Cases of Sacroiliac Strain During and After Spontaneous Labor
Dae Yong HAN ; Jun Seop JAHNG ; Jae Yung HYUN
The Journal of the Korean Orthopaedic Association 1982;17(3):492-495
Mechanically the symphysis pubis serves to anchor the ends of the two weight bearing arches of the pubis-the femorosacral and ischiosacral arches. Under normal conditions it has been found to exceedingly resistant to separation. Sacroiliac strain is also uncommon because the sacroiliac ligaments are very strong and the movement which produce a torsion strain upon the joint is more likely to cause a strain of thinner capsular ligaments surrounding the small lumbosacral joints. We experienced a case of separation of the symphysis pubis and 2 cases of sacroiliac strain during and after spontaneous labor.
Joints
;
Ligaments
;
Pubic Bone
;
Weight-Bearing
2.The Relationship between Human Neutrophil Elastase and Coronary Arterial Dilatation in Kawasaki Disease .
Jun Yong SHIM ; Hee Won CHOI ; Ja Hyun HONG ; Jong Kyun LEE ; Hae Yong LEE
Journal of the Korean Pediatric Society 2003;46(9):903-908
PURPOSE: Kawasaki disease is notorious for coronary arterial complication which is usually developed as a febrile disease in early childhood. Increased polymorphonucleus(PMN) cell levels in acute phases may be associated with the pathophysiology of Kawasaki disease. We studied the relationship between coronary arterial dilatation and elastase activity which was excreted from PMN cell and roles as an important factor for vasculitis. METHODS: Ten patients diagnosed with Kawasaki disease in Yonsei University Medical Center were examined between November, 2001 and January, 2002. In addition, 15 patients with other febrile diseases were also examined. Echocardiography was done in patients with Kawasaki disease on the first day of admission and four weeks after the onset of the disease. At each time, venous samples were drawn and separated into plasma and leukocytes. In patients with other febrile disease, samples were drawn on admission. Elastase activities in plasma and neutrophil extracts were measured. RESULTS: The significant increased plasma elastase activity, 6.19+/-0.74 U/mL, found in Kawasaki disease patients compared with the other febrile disease patients, 4.86+/-1.17 U/mL(P<0.05). And there was no significance between the above two diseases in terms of the elastase activity in neutrophil extracts. The relationship between initial elastase activity and the coronary arterial complication which was shown in subacute phase wasn't significant. CONCLUSION: Plasma elastase activity was increased in Kawasaki disease significantly, but the initial plasma elastase activity in the acute phase could not reflect the range of coronary arterial complication.
Academic Medical Centers
;
Dilatation*
;
Echocardiography
;
Humans*
;
Leukocyte Elastase*
;
Leukocytes
;
Mucocutaneous Lymph Node Syndrome*
;
Neutrophils*
;
Pancreatic Elastase
;
Plasma
;
Vasculitis
3.A case of heterotopic pregnancy: 16 weeks of intrauterine pregnancy with fetal Edwards syndrome and tubal pregnancy, following IVF-ET.
Doo Yong CHUNG ; Hyun Su JEON ; Hyun Jun KIM
Korean Journal of Obstetrics and Gynecology 2008;51(1):89-94
Heterotopic pregnancy is defined as coexistence of intrauterine and ectopic pregnancy. The reported incidence of heterotopic pregnancy, which is normally rare, is particularly high (1%) after IVF treatment. It is important to have a high index of suspicion for the occurrence of heterotopic pregnancies because only 40% to 84% of cases can be diagnosed with transvaginal ultrasound at the initial presentation. Edwards syndrome occurs in 8,000 newborns and the incidence is much higher in elderly gravidas. We report a case of heterotopic pregnancy following IVF-ET resulting in 16 weeks of intrauterine pregnancy with fetal Edwards syndrome, and tubal pregnancy with a brief review of literature.
Aged
;
Female
;
Humans
;
Incidence
;
Infant, Newborn
;
Pregnancy
;
Pregnancy, Ectopic
;
Pregnancy, Heterotopic
;
Pregnancy, Tubal
4.Effect of BMI1 Knockdown on Cell Proliferation, Apoptosis, Invasiveness, and Migration of U251 Glioma Cells.
Dong Joon KIM ; Yong Hyun JUN ; Dong Hyun KIM ; Jong Joong KIM
Korean Journal of Physical Anthropology 2015;28(2):69-78
BMI1 belongs to the polycomb-repressive complex 1 (PRC1) family of genes that are conserved chromatin silencers. These are essential for maintaining both the normal and cancerous stem cell state. In this study, we evaluated the effect of siRNA-mediated BMI1 knockdown on tumor cell properties such as invasion, migration, and apoptosis, as well as on cell signaling pathways responsible for tumor progression in the human glioma cell line, U251. Knockdown of BMI1 induced apoptosis by activating cleavage of PARP and caspase-3. It also decreased the expression of anti-apoptotic proteins, survivin, XIAP, Bcl-xL, and Mcl1. Additionally, BMI1 knockdown significantly decreased cell invasion and cell migration ability. BMI1 knockdown also decreased the phosphorylation of Akt/FOXO1/3a signaling proteins. Our results suggest that BMI1 knockdown induces apoptosis and decreases cell invasion and cell migration. Moreover, we believe these phenomenona are associated with decreased phoshorylation of Akt signaling proteins, which contributes to cancer progression.
Apoptosis Regulatory Proteins
;
Apoptosis*
;
Caspase 3
;
Cell Line
;
Cell Movement
;
Cell Proliferation*
;
Chromatin
;
Glioma*
;
Humans
;
Phosphorylation
;
Stem Cells
5.Recurred Left Atrial and Left Ventricular Myxoma after Surgical Excision of Biatrial Atrial Myxoma.
Young Tae KIM ; Yong Hak BAE ; Hun Sik PARK ; Ji Yong CHOI ; Jin Yong HWANG ; Yong Keun CHO ; Shung Chull CHAE ; Jae Eun JUN ; Wee Hyun PARK
Korean Circulation Journal 1996;26(5):1068-1073
We report on a 28 years old female with recurred cardiac myxomas who presented with dizziness, headache, and blurred vision. She had an excision of biatrial atrial myxomas 10 years age. Varying sized multiple cerebral aneuysms and myxomas in left atrium and left ventricle were found on a cerebral angiogram and echocardiogram, respectively. After wide excision including interatrial septum and part of left ventricular septum, her symptoms were much improved.
Adult
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Dizziness
;
Female
;
Headache
;
Heart Atria
;
Heart Ventricles
;
Humans
;
Intracranial Aneurysm
;
Myxoma*
;
Ventricular Septum
6.Effect of Magnesium Ion in the Culture Medium on the Development of Preimplantation Mouse Embryos In Vitro.
Soo Jin CHOI ; Jin Hyun JUN ; Yong Seog PARK ; In Ha BAE
Korean Journal of Fertility and Sterility 2001;28(3):199-208
OBJECTIVE: The present study was undertaken to examine the effects of magnesium ion in the culture medium on the development of mouse fertilized oocytes either before or after pronuclear formation, and to investigate whether the effect of magnesium ion is related with the redistributional change of mitochondria. METHODS: Fertilized oocytes obtained from the oviducts of mice at 15 hr after hCG injection before pronuclear formation (pre-PN) or 21 hr after hCG injection after pronuclear formation (post-PN) were used. The embryos were cultured for 3 days with basic T6 medium-magnesium free and various concentrations of magnesium ion, 0.0, 0.5, 1.0, 2.0, 4.0 or 8.0 mM, respectively. After culture, the developmental stages of embryos and the number of nuclei were evaluated. To observe the effects of magnesium ion on the mitochondrial distribution, fertilized oocytes were collected at 21 hr after hCG injection and cultured for 6 hr with various concentration of magnesium ion. As a control, fertilized oocytes with pronuclei at 27 hr after hCG injection were used. RESULTS: The concentration of magnesium ion to accelerate the in vitro development of mouse fertilized oocytes appeared to be at 2.0 mM for the pre-PN and the post-PN stage embryos. In the mitochondrial redistribution patterns, the embryos cultured in 2.0 mM concentration of magnesium ion showed the highest percentage (22.6%) of distinct perinuclear clustering pattern comparing to other experimental group. CONCLUSION: The effect of magnesium ion may be related to the cytoplasmic redistribution of mitochondria. This relationship seems to connect the developmental competence of preimplantation mouse embryos in vitro. These results can suggest that higher concentration of magnesium ion (2.0 mM) than those of conventional culture medium (0.2~1.2 mM) is more suitable for in vitro culture of preimplantation mouse embryos.
Animals
;
Cytoplasm
;
Embryonic Structures*
;
Magnesium*
;
Mental Competency
;
Mice*
;
Mitochondria
;
Oocytes
;
Oviducts
7.A Study of Mucocutaneous Manifestations Due to Cancer Chemotherapy.
Yong Sub OH ; Seong Hyun HONG ; Young Chul KYE ; Jun Seok KIM ; Chil Hwan OH
Korean Journal of Dermatology 1995;33(3):474-481
BACKGROUND: Recently, inireaing numbers of chemotherapeutic agens are being used to treat cancer patients. Mucocutaeous complications are commonly sen in association with the administration of these medicaticins. OBJECTIVE: We conducted a study in cancer chemotherapy patient so determine the suspected chemotherapeutic agents ancl frequency of various mucocutaneous side effects in these patients. METHODS: The study involved 140 patients admitted from Decerrae 1993 to September 1994 for cancer chemot herapy at Korea University Guro Hospital. RESULTS: The mucocutaneous side effects during chemotherapy were alopecia(55%), hyperpig mentation(32.9%), stomatitis(20%), phlebitis(12.9%), flushing(8.6%) descending order. Visual grade II, IV alopecia patients were most common, but as the chemot retpy cycle increased so, the severer the alopecia. Although the onset of the alopecia were variake many patients experienced alopcia within 17 to 24 days after the start of chemotherapy. Serpeitie supravenous fluorouracil hyperpigmentation were commor,(17.9%), Diffuse and longitudinal or horizontal band like nail pigmentation were observed, and, pigmented macules were also observei, epecially on the palms and digits. Stomatitis usually developed within 10 days after the start of chemotherapy and it persist ed for about 7 days and the most of the lesions were resolved spor Laeously. Other clinical manifestations accompanied with chmotherapy were tinea infection(16.4%), acne(7.1%), oral thrush (7%), white nail band(4.3%), pruritus(2.9%) in descending order. CONCLUSION: So, physiciars need to be aware of the widely divergnal cutaneous reactions which may occur with the use of antiancer medications.
Alopecia
;
Candidiasis, Oral
;
Drug Therapy*
;
Fluorouracil
;
Humans
;
Hyperpigmentation
;
Korea
;
Pigmentation
;
Stomatitis
;
Tinea
8.A Case of Localized fibrous tumor of Pelvic Cavity.
Chun Ju LEE ; Byung Jin JANG ; Hyun Jun PARK ; Sung Yong KIM ; Hae Young PARK
Korean Journal of Urology 2001;42(1):124-126
Localized fibrous tumor is an uncommon submesothelial origin tumor found in pleura most commonly. Sixty five-year-old man with right lower quadrant pain was admitted. He was treated with resection of tumor and was diagnosed as localized fibrous tumor of pelvic cavity. He is now being followed up without any evidence of recurrence for 34 months. This case is presented with reviewing references.
Pleura
;
Recurrence
9.Efficacy of teicoplanin in gram-positive bacterial infection.
Ji So RYU ; Jun Hee WOO ; Kee Won KIM ; Hyun Tae KIM ; Yong Hun KIM
Korean Journal of Infectious Diseases 1992;24(3):183-189
No abstract available.
Gram-Positive Bacterial Infections*
;
Teicoplanin*
10.Clinical observation on brainstem glioma in childhood.
Hyun Jun CHO ; Se Hee HWANG ; Yong Seung HWANG ; In Won KIM
Journal of the Korean Pediatric Society 1991;34(4):532-543
No abstract available.
Brain Stem*
;
Glioma*