No abstract available.
Peripheral Nerves* ; Rabbits* ; Regeneration*

Peroxisome proliferator-activated receptor-gamma (PPARgamma) has been implicated in the growth inhibition of a number of cancer cells. In the present study, we investigated the antitumor effect of the PPARgamma agonist rosiglitazone in U87MG human glioma cells. Rosiglitazone treatment in vitro reduced cell proliferation without induction of cell death in a dose- and time-dependent manner. Rosiglitazone decreased cell migration and mRNA level of MMP-9. Rosiglitazone treatment also induced marked changes in glioma cell morphology. Oral administration of rosiglitazone in animals with subcutaneous U87MG glioma cells reduced tumor volume. Subsequent tumor tissue analysis showed that rosiglitazone decreased the number of PCNA-positive staining cells and MMP-9 expression and induced apoptosis of tumor cells. These data suggest that rosiglitazone exerts antineoplastic effect in U87MG cells and may serve as potential therapeutic agent for malignant human gliomas.
Administration, Oral ; Animals ; Apoptosis ; Cell Death ; Cell Movement ; Cell Proliferation ; Glioma ; Humans ; Peroxisomes ; PPAR gamma ; RNA, Messenger ; Thiazolidinediones ; Tumor Burden

Intussusception is the most common cause of acquired intestinal obstructions during infancy and early childhood. Barium reduction and pneumoreduction have been sued widely as nonsugical method of treatment in radiologic department. In the past, attempts at barium reduction of intussusception were contraindicated in the presence of frank intestinal obstruction, shock, fever, dehydration, bowel perforation, peritonitis and longstanding symptoms. At present, however, there is no agreement on the contraindications, except for shock, peritonitis and bowel perforation. Especially, there is no consensus regarding its application on patient presenting with sign of frank intestinal obstruction. The authors analyzed the effect of pneumoreduction in the intussusception with sign of frank intestinal obstruction. Pneumoreduction was attempted in 53 cases of intussusception with sign of frank intestinal obstruction. Reduction was successful in 43 cases(81%). The mean fluroscopic time was 15.1 minutes and mean maximal pressure was 121.8mmHg in successful reduction. As complications, two cases of bowel perforation were observed, but could be treated surgically without any significant problem. In conclusion, pneumoreduction is a useful substitute for barium reduction in the management of pediatric intussusception with sign of frank intestinal obstruction.
Barium ; Consensus ; Dehydration ; Fever ; Humans ; Intestinal Obstruction* ; Intussusception* ; Methods ; Peritonitis ; Shock

A case of rare subcutaneous sparganosis in thigh treated by surgical excision is reported. In this 49year-old male with a palpable mass on the anteromedial aspect of mid-thigh (5x7x5cm sized) which was misdiagnosed with a soft tissue tumor initially, a sparganosis was suspected by a plain x-rays, bone scan and his past history which he frequently had raw snakes, frogs and raw fishes before but confirmed by MRI and surgical excision. This represents tor warning to some Koreans who have frequently comsumed raw fishes, snakes or frogs etc., and to some doctors because it is easily confused with a soft tissue tumor.
Fishes ; Humans ; Magnetic Resonance Imaging ; Male ; Snakes ; Sparganosis* ; Subcutaneous Tissue* ; Thigh*

Cardiac transplantation has become an acceptable therapy for patients with end stage heart disease over the last decade. We experienced a case of heart transplantation to the 50 year old female patient. We used sterile technique all the time to reduce the incidence of infection. Anesthesia was induced and maintained with fentanyl 100 ug/kg. After cardiopulmonary bypass, blood products, inotropics and vasodilators were given to maintain myocardial contractility and cardiac output. The patient recovered uneventfully and discharged on 29th postoperative day.
Anesthesia* ; Cardiac Output ; Cardiopulmonary Bypass ; Female ; Fentanyl ; Heart Diseases ; Heart Transplantation* ; Heart* ; Humans ; Incidence ; Middle Aged ; Vasodilator Agents

No abstract available.
Carcinoma, Transitional Cell*

No abstract available.
Hematoma*

No abstract available.
Breast Neoplasms* ; Breast*

Of several possible configurations of pin fixation of a displaced supracondylar fracture of the humerus in children, the medial and lateral crossed pinning technique has been known to provide the greatest resistance to gross rotational displacement. A new technique with ipsilateral two lateral crossed pins was devised so as to avoid the ulnar nerve injury with good stability for fracture site. During the period from 1992 to 1994, 18 children with displaced supracondylar fracture of the humerus were treated by closed reduction and ipsilateral two lateral crossed pinning. Eighty nine percents of the final results were satisfactory. There were no ulnar nerve injuries and fixation loss in all cases from the treatment. This is a safe, simple and reliable technique for providing the good stability of fracture site as well as avoiding the ulnar nerve injury.
Child ; Humans ; Humerus ; Ulnar Nerve ; Ulnar Neuropathies ; United Nations

PURPOSE: The purpose of this study is to find out the possibilities of the early treatment via artificial juxtacrine stimulation by photo-immobilization of growth factor in the anterior cruciate ligament (ACL) injury. MATERIALS AND METHODS: Photo-reactive Epidermal Growth Factor (EGF-Az) was synthesized by conjugating EGF with N-(4-azidobenzoyloxy)succinimide and was immobilized onto the polystyrene culture plates by UV irradiation. Human ACL cells (1 x 10 5 cells/ml , 100 m l /well) were cultured with serum free media in each group (group 1 : no EGF, group 2 : native EGF 2 m g /ml , group 3 : 50 m l EGF-Az immobilization, group 4 : 100 m l EGF-Az immobilization). We observed the changes of cells with long-term culture and compared the difference of cellular response of EGF-treated and non-treated groups. To examine the cellular migration, in vitro wound closure assay was performed. RESULTS: Cells were proliferated for 3 days. It was not changed significantly after that time. Cellular growth was more remarkable in the photo-immobilized EGF group. In cell migration test, the defect site in the photo-immobilized group was indistinguishable from the non-scratched area after culture for 72 hours, while cellfree area was still clearly visible in the no EGF group. CONCLUSION: Photo-immobilized EGF induce rapid proliferation of fibroblasts via artificial juxtacrine stimulation. If EGF is immobilized onto bioabsorbable materials such as polyglycolic acid or polylactic acid for clinical application, it will contribute to the treatment of ACL.
Anterior Cruciate Ligament* ; Cell Movement ; Culture Media, Serum-Free ; Epidermal Growth Factor* ; Fibroblasts ; Humans ; Immobilization ; Knee* ; Polyglycolic Acid ; Polystyrenes ; Wounds and Injuries