1.Surgical Experiences of Three Cases of Giant Pituitary Adenoma.
Hyun Won CHO ; Han Kyu KIM ; Yong Soon HWANG ; Tae Sang CHUN ; Hwa Dong LEE
Journal of Korean Neurosurgical Society 1990;19(8-9):1221-1230
Three cases of giant pituitray adenoma are reported. Two cases were operated by transsphenoidal approach and a case by transcranial approach. Transsphenoidal approach showed satisfactory results despite of marked suprasellar extension of tumors. We report rare giant pituitary adenomas with review of relevant literatures.
Adenoma
;
Pituitary Neoplasms*
2.Serum and Urine Zinc Values in Infectious Diseases.
Yong Tai SUH ; Hwa Young KIM ; Jai Sook MAH ; Tai Ju HWANG
Journal of the Korean Pediatric Society 1984;27(3):237-245
No abstract available.
Communicable Diseases*
;
Zinc*
3.Two cases of primary ovarian transitional cell carcinoma.
Yuan Fung SUN ; Young Woo JANG ; Yong Hwa HWANG ; Sueng Kwon KOH ; Sook CHO ; Byung Moon KANG ; Goo Sang KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1039-1046
No abstract available.
Carcinoma, Transitional Cell*
4.Steroid Psychosis.
Jae Gon MOON ; Jin Hak KIM ; Yong Soon HWANG ; Hwa Dong LEE
Journal of Korean Neurosurgical Society 1994;23(7):809-815
The use of steroids has long been reported many side effects. Steroid-induced mental disorder is one of many complications associated with corticosteroid therapy. Steroid psychosis is not common disease but it may be more popular due to high steroid therapy such as pulse therapy or high dose steroid therapy. Euphoria, irritability, insomnia, and hallucination are predominating symptoms. The dosage, duration of the treatment may not be correlated with the time of the onset, duration, severity, or type of mental disturbances, but the risk of developing psychosis is increased to the high dose of steroid. It is usually reversible on dose reduction or discontinuation of the drug.
Euphoria
;
Hallucinations
;
Mental Disorders
;
Psychotic Disorders*
;
Sleep Initiation and Maintenance Disorders
;
Steroids
5.MR Imaging of Childhood Metachromatic Leukodystrophy.
Yun Sun CHOI ; Jae Young LEE ; Tae Sung KIM ; In One KIM ; Kyung Mo YEON ; Ok Hwa KIM ; Yong Seung HWANG
Journal of the Korean Radiological Society 1995;33(3):433-437
PURPOSE: The purpose of this study was to analyze the characteristic MR findings of childhood metachromatic leukodystrophy. MATERIALS AND METHODS: Five female patients (10--29 months old;mean age, 21.8 months) of biochemically confirmed metachromatic leukodystrophy were included in this study. We evaluated the extent of white matter degeneration, which was shown as high signal intensity on T2-weighted image, and the presence or absence of the enhancement. Result.' All 5 cases showed high signal intensity in periventricular deep white matter and centrum semiovale which were bilateral, symmetric and confluent. Posterior predominace, sparing of subcortical U fibers and immediate periventricular white matter, and the involvement of splenium of corpus callosum were also noted in all cases. There were other manifestations, such as 'tigroid pattern' in centrum semiovale (n=4), the involvement of genu of corpus callosum(n=4), posterior limb of internal capsule(n=4), descending pyramidal tracts (n=3), deep cerebellar white matter(n=1), claustrum(n=2), and diffuse brain atrophy(n=1). In three cases with Gd-infusion, contrast enhancement of the lesion was not seen. CONCLUSION: In childhood metachromatic leukodystrophy, MRI can clearly demonstrate the chracteristic extent of the white matter lesion and other associated findings, facilitating the differential diagnosis from other similar leukodystrophies.
Brain
;
Corpus Callosum
;
Diagnosis, Differential
;
Extremities
;
Female
;
Humans
;
Leukodystrophy, Metachromatic*
;
Magnetic Resonance Imaging*
;
Pyramidal Tracts
6.Rupture and Spontaneous Sealing of a Coronary Aneurysm After Deployment of Drug-Eluting Stent.
Tae Jung KWON ; Jin Yong HWANG ; Choong Hwan KWAK ; Young Hoon JEONG ; Yong Whi PARK ; Seok Jae HWANG ; Jeong Rang PARK ; Jong Hwa AHN ; Ji Hyun MIN
Korean Circulation Journal 2012;42(8):558-561
Lesions with coronary artery aneurysm (CAA) can become complicated during percutaneous coronary intervention. Here, we report a case of a 78-year-old man who developed a rupture, and spontaneous sealing of the CAA occurred after stent implantation, as shown by computed tomography coronary angiography.
Aged
;
Aneurysm
;
Congenital Abnormalities
;
Coronary Aneurysm
;
Coronary Angiography
;
Coronary Vessels
;
Drug-Eluting Stents
;
Ear
;
Humans
;
Percutaneous Coronary Intervention
;
Rupture
;
Stents
7.Diagnosis of Herpes Simplex Virus Encephalitis by Polymerase Chain Reaction.
Eun Hwa CHOI ; Ki Joong KIM ; Hoan Jong LEE ; Yong Seung HWANG ; In One KIM
Korean Journal of Infectious Diseases 1999;31(1):17-24
BACKGROUND: Herpes simplex virus encephalitis (HSVE) is a severe disease resulting in high mortality rates and residual sequelae; therefore, early diagnosis and treatment are very important. The purpose of this study was to evaluate the usefulness of polymerase chain reaction (PCR) assay of HSV DNA in cerebrospinal fluid (CSF) from patients with encephalitis for confirmatory diagnosis of herpes simplex virus encephalitis. MATERIALS AND METHODS: PCR analysis was done to detect DNA of HSV in 31 CSF samples obtained from 21 patients with encephalitis, admitted between November 1994 and June 1996, at the Seoul National University Children's Hospital. As controls, 15 samples from patients with proven diseases other than encephalitis were tested. Two different 22 bp- rimers, complementary to sequences within the DNA polymerase regions of HSV gene, were used. After amplification, PCR products were digested with DdeI to confirm the sequence. RESULTS: Three CSF specimens from 2 out of 21 patients with encephalitis were positive for HSV DNA, whereas all the control specimens were negative. PCR was positive in CSF samples obtained at 3 and 7 days after onset of symptoms from one patient and at 5 days from the other. PCR analysis yielded negative results in CSF samples collected at 10 and 14 days after acyclovir treatment. CONCLUSION: In this study, HSVE was diagnosed by PCR amplification of HSV genome from CSF obtained at early stage of the disease from patients with encephalitis. PCR assay of CSF samples could be used for early and confirmatory diagnosis of HSVE.
Acyclovir
;
Cerebrospinal Fluid
;
Diagnosis*
;
DNA
;
Early Diagnosis
;
Encephalitis
;
Genome
;
Herpes Simplex*
;
Humans
;
Mortality
;
Polymerase Chain Reaction*
;
Seoul
;
Simplexvirus*
8.Inflammatory Pseudotumor in the Lateral Ventricle with Repeated Bleeding: Case Report.
Jong Hwa PARK ; Taek Kyun NAM ; Sung Nam HWANG ; Seung Won PARK
Journal of Korean Neurosurgical Society 2009;45(2):99-102
Inflammatory pseudotumor is an uncommon lesion with unknown etiology characterized by sclerosing inflammation which clinically and radiographically mimics a neoplastic lesion. A 47-year-old man presented with sudden headache and dysarthria. Brain CT scan revealed a 2.6x2.2 cm sized, round, and hyperdense mass in the anterolateral wall of the left lateral ventricular trigone. On MR imaging studies, the mass showed low signal intensity in the wall of the trigone on T2-weighted image, central mixed (iso- and high-) signal intensity with peripheral low-signal intensity on T1-weighted image. Subtle staining of left choroid plexus with irregular shaped distal branch of anterior choroidal artery was found on the cerebral angiography. These findings suggested a small tumorous lesion originated from the left choroid plexus. During the hospital days, the mass manifested as repeated hemorrhages. The mass was successfully removed via left occipital transcortical approach. The histopathological report of the specimen was hemorrhage and fibrosis, with dense lymphoplasma cell infiltration, suggestive of an inflammatory pseudotumor.
Arteries
;
Brain
;
Cerebral Angiography
;
Choroid
;
Choroid Plexus
;
Dysarthria
;
Fibrosis
;
Granuloma, Plasma Cell
;
Headache
;
Hemorrhage
;
Humans
;
Inflammation
;
Lateral Ventricles
;
Middle Aged
9.A Trial of Hyperfractionated Radiotherapy in Supratentorial Gliomas.
Seog Won CHEONG ; Han Kyu KIM ; Young Soon HWANG ; Hwa Dong LEE ; Ha Yong YUM
Journal of Korean Neurosurgical Society 1991;20(12):1059-1068
Fractionation dose and number have been known as radiation factor affecting the radiation complication and the effectiveness in radiotherapy for brain tumors. In this study hyperfractionation technique with 115cGy/fractioin 2 fractions daily 5days/wk, upto 5750-6900cGy to partial brain volume was compared with conventional fractionation technique with daily 200cGy/fraction 5 fraction/wk, upto 5400-6000cGy, in regarding to the effectiveness of hyperfractionated radiotherapy and eraly and later radiation reavtion. The survival period was longer in hyperfractionated irradiated group particularly if the tumors were located in the posterior portion of brain, however there was no singificant statistics due to small number of patients. Mean survival period for glioblastoma multiforme was 11.8 months in hyperfractionated group vs 8.7 months in conventional fractionated group and for high grade astrocytoma 36month in hyperfractionated group, but in conventional fractionated group all was died in 18 months. Acute radiation reaction occurred less frequently in hyperfractionated group, 15.8% vs 47.8% in conventional fractionated group(p<0.024). Alopeci was developed in 31.6% of the hyperfractionated group vs 82.6% of the conventional fractionated group(p<0.0031). One case of later radiation necrosis in cancer region was suspected in the hyperfractionated group but we has been in a dilemma for confirmatory diagnosis in present available diagnostic technique. The hyperfractionated irradiation technique was proven to be superior to conventional fractionated technique regarding the radiation reaction and the effectiveness of the treatment.
Astrocytoma
;
Brain
;
Brain Neoplasms
;
Diagnosis
;
Glioblastoma
;
Glioma*
;
Humans
;
Necrosis
;
Radiotherapy*
10.The Central Infarctions after Surgery for Anterior Circulation Aneurysm.
Sung Woo SEO ; Han Kyu KIM ; Jae Gon MOON ; Yong Soon HWANG ; Hwa Dong LEE
Journal of Korean Neurosurgical Society 1993;22(12):1324-1334
Among the series of 272 cases of surgically treated anterior circulation aneurysms, we experienced 6 cases of central infarctions involving caudate nucleus, globus pallidus, putamen and genu of internal capsule respectively or in combination. These surgery related complications were caused by the injury to the perforators going to the anterior perforated substance during manipulation of the large aneurysm or the aneurysms ruptured prematurely. The clinical courses of these patients, however, were not so severe. The morbidities were minimal or none after the average follow-up periods of 17 months. Thorough knowledge of the anatomy of the perforators may help to minimize the severe morbidity in the management of large or difficult aneurysms.
Aneurysm*
;
Caudate Nucleus
;
Follow-Up Studies
;
Globus Pallidus
;
Humans
;
Infarction*
;
Internal Capsule
;
Olfactory Pathways
;
Putamen