1.Effects of Ketamine and Pentobarbitone on Degeneration of Oocyte and of Granulosa Cells in Mouse Ovary.
Korean Journal of Fertility and Sterility 1998;25(2):179-187
In mammal, lots of follicles start simultaneously their growth but only a few oocytes are ovulated in every sexual cycles. Most of matured and grown oocytes are destined to degenerate by atresia. However, the molecular and physiological mechanisms are not elucidated yet. The present study was designed to establish an induction method of follicular atresia with ketamine or pentobarbitone and evaluate the effect of these anesthetics on oocyte maturation and granulosa cell apoptosis of the mouse ovarian follicle. The percentages of degenerated oocyte and apoptotic granulosa cell in ketamine treated groups were significantly higher than that in controls (58.9% vs 33.5%, p<0.01, degeneration; 44.9% vs 26.6%, p<0.01, apotosis). Futhermore, it was revealed that the concentrations of progesterone in both groups were markedly higher than that in control. In conclusion, it is considered that ketamine induce an atresia as pentobarbitone, and may be useful for inducing follicular atresia.
Anesthetics
;
Animals
;
Apoptosis
;
Female
;
Follicular Atresia
;
Granulosa Cells*
;
Ketamine*
;
Mammals
;
Mice*
;
Oocytes*
;
Ovarian Follicle
;
Ovary*
;
Pentobarbital*
;
Progesterone
2.The toxic effects of cryoprotectants on the mouse embryo.
Chung Hoon KIM ; Shin Yong MOON ; Yoon Seok CHANG
Korean Journal of Obstetrics and Gynecology 1991;34(10):1400-1409
No abstract available.
Animals
;
Embryonic Structures*
;
Mice*
3.Axisymmetric Contact Stress analysis of an Artificial Hip Joint of the Conical Fitting Type
Yong San YOON ; Young Yong KIM ; Kye Lim LEE ; Seung Key KIM ; Young Hoon KANG
The Journal of the Korean Orthopaedic Association 1989;24(6):1665-1672
The purpose of this study is to investigate the effect of the ball-cone contact interface variation on the ceramic ball stress which is the dominant factor of the design of the moldular artificial hip joint. A contact stress analysis problem is formulated using the optimization principle and finite element analysis technique on the ball-cone system of three dimensional axi-symmetrical model, Numerical procedure is employed to get the solution for varying angles of cones and angular mismatches between the ball and cone interfaces. There is a fair amount of friction in the interface and included in the analysis model.
Ceramics
;
Finite Element Analysis
;
Friction
;
Hip Joint
;
Hip
4.The diagnostic value of computed tomography in obstructive jaundice
Yong Dae CHOI ; Young Ja YOON ; Sang Hoon BAE ; Kyung Yong LEE
Journal of the Korean Radiological Society 1982;18(4):759-766
Computed tomographic (CT) scans of 46 jaundiced patients were studied to determine the value of CT in the diagnosis of biliary pathology. AII ofthe 12 cases of medical jaundice had positive CT correlation. Of the 34 cases of proven surgical jaundice, 97 .8% were correctly identified by CT. In detecting the level of obstruction, the cases were divided into four groups by anatomica l segments, according to the number of visualized low density ringlike structures produced by dilated bile duct. All of the correctly diagnosed surgical jaundice was 91.2%. The presence of stones or mass, the level of obstruction and the relative size and shape of visualized distal ring had proved to be the most important variables in etiological diagnosis of surgical jaundice. The results indicate that CT is useful and highly accurate in differenting between surgical (obstructive) jaundice and medical (non-obstructive) ajundice, and determining the level of obstruction and the etiology of surgical jaundice.
Bile Ducts
;
Diagnosis
;
Humans
;
Jaundice
;
Jaundice, Obstructive
;
Pathology
5.Left Atrial Spontaneous Echo Contrast and Thrombus in Nonrheumatic Atrial Fibrillation.
Yeo Hak YOON ; Young Kwon KIM ; Yoon Suk CHO ; Bong Nam CHAE ; Jin Yong CHOI ; In SOHN ; Seong Hoon PARK
Korean Circulation Journal 1994;24(1):66-76
BACKGROUND: Nonrheumatic atrial fibrillation is common in elderly and associated with an increased risk for thromboembolism. Left atrial spontaneous echo contrast(SEC) and thrombus. which are easily detected by transesophageal echocardiography(TEE) in patients with rheumatic mitral valve disease and atrial fibrillation, have been known as markers of thromboembolism. However, most of the previous studies on left atrial SEC and thrombus were performed in rheumatic mitral valve disease or various conditions including rheumatic mitral valve disease. Therefore this study was underaken in order to investigatd 1) the prevalence of left atrial SEC and thrombus, and 2) clinical and echocardiographic variables related to left atrial SEC and thrombus in nonrheumatic atrial fibrillation. METHODS: In patients with estabished atrial fibrillation over 7 days, we examined the clinical gistory and performed transthoracic echocardiography(TTE) and TEE simultaneously. Enlisted patients were those without rheumatic mitral valve disease, prosthetic valves, previous thromboembolism, and recent anticoagulant therapy. RESULTS: 1) Left atrial SEC was detected in 32(62.7%) of 51 patients and left atrial thrombus in 10(19.6%). All thrombi were located in the left atrial appendage. 2) In univariate analysis, SEC positive group showed higher prevalence of congestive heart failure(CHF)(56.3% vs 0%, p<0.001), lower ejection fraction(42.2+/-14.1% vs 50.8+/-9.7%, p<0.05), lower left atrial appendage blood flow velocity(peak positive flow velocity ; 18.7+/-11.1cm/sec vs 32+/-12.4cm/sec, p<0.01, and peak negative flow velocity ; 21.4+/-12.4cm/sec vs 31.9+/-12.8cm/sec, p<0.01) than SEC negative group. Multivariate analysis identifed CHF as an independent variable related to left atrial SEC(p=0.02, Odds ratio ; 2.38, 95% CI ; 1.18-4.82). 3) In univariate analysis. left atrial thrombus positive group showed higher prevalence of CHF(70% vs 26.8%, p<0.05), larger left atrial demension(34+/-3.4mm/m2 vs 30.6+/-4.6mm/m2, p<0.05) than thrombus negative group. Multivariate analysis identifed CHF as an independent variable related to left atrial thrombus(p=0.04, Odds ratio ; 4.30, 95% CI ; 1.11-16.68). 4) Left atrial thrombus is more frequent in SEC positive group than in SEC negative group(28.1% vs 5.3%), however, there was no statistical significance(p=0.07). CONCLUSION: 1) Left atrial SEC is common in nonrheumatic atrial fibrillation and significantly related to CHF. 2) Left atrial thrombus is frequently detected in SEC positive patients, however, it is more realted to CHF than left atrial SEC itself.
Aged
;
Atrial Appendage
;
Atrial Fibrillation*
;
Echocardiography
;
Estrogens, Conjugated (USP)
;
Heart
;
Humans
;
Mitral Valve
;
Multivariate Analysis
;
Odds Ratio
;
Prevalence
;
Thromboembolism
;
Thrombosis*
6.The 24-Hour Ambulatory Blood Pressure in Normotensive Korean Adults.
Bong Nam CHAE ; Young Kwon KIM ; Yeo Hak YOON ; Yoon Sook CHO ; Jin Yong CHOI ; In SOHN ; Seong Hoon PARK
Korean Circulation Journal 1994;24(1):9-16
BACKGROUND: Twenty-four-hour ambulatory blood pressure(ABP) monitoring has become increasingly popular for diagnosing and treating hypertension. Therefore the reference value of normotensive subjects was necessary for interpretation of hypertensive subjects. Several studies were reported on reference values in normotensive subjects. The purpose of this study was to determine 24-hour ABP in normotensive Korean adults stratified for sex and five age groups. This study also assessed ABP in relation to a family history of hypertension, smoking and body mass index(BMI). METHODS: ABP monitoring was performed in 200 healthy normotensive volunteers(ranged in age from 20 to 69 years, five decades, 20 men and 20 women per each decade), over 24 hours, taking measurement at 30-min intervals. The 24-hour interval was divided into day-time(6am-10pm) and night-time(100pm-6am) periods. Mean ABP and pressure loads(percentage of systolic readings>140mmHg, diastolic readings>90mmHg) were obtained. RESULTS: The mean ABP in 200 subjects was 113+/-8.6/72+/-6.9mmHg over 24 hours, 117+/-9.7/75+/-7.0mmHg during day-time, and 106+/-9.8/67+/-8.3mmHg at night-time, and pressure loadd averaged 5.1+/-7.4/7.9+/-8.9% over 24 hours. The +2 standard deviation(SD) as the upper limit of normal was 130/86mmHg over 24 hours in 200 subjects. The mean ABP and pressure load were 116+/-7.6/74+/-7.6mmHg and 6.4+/-8.3/10.1+/-10.2% in 100 subjects of men, and 110+/-8.3+/-70+/-6.6mmHg, 3.7+/-6.0/5.7+/-6.8% in women. Mean ABP and pressure load showed significant difference in relation to age group and sex, however, no significant difference in relation to a family history of hypertension or smoking. In relation to BMI group, diastolic blood pressure and diastolic pressure load were significantly different.
Adult*
;
Blood Pressure*
;
Female
;
Humans
;
Hypertension
;
Male
;
Reference Values
;
Smoke
;
Smoking
7.Results of Posterior Cruciate Retained Total Knee Arthroplasty in Patients with Flexion Deformity: In Comparison with Posterior Stabilized Type.
Yong Hoon KIM ; Keun Woo KIM ; Hak Jin MIN ; Eui Seoung YOON ; Sang Lim KIM ; Yoon Jong KIM
Journal of the Korean Knee Society 2001;13(2):142-147
No Abstract Available.
Arthroplasty*
;
Congenital Abnormalities*
;
Humans
;
Knee*
8.Pregnancy Outcome According To Elapsing Time After An Immediate Administration Of Antibiotics In A Rabbit Model For The Intrauterine Infection.
Shin Yong MOON ; Bo Hyun YOON ; Hee Chul SYN ; Gyo Hoon PARK
Korean Journal of Obstetrics and Gynecology 1999;42(1):30-40
OBJECTIVE: In a pregnant rabbit model using hysteroscopy-guided inoculation of E. coli, we investigated pregnancy outcome according to elapsing time with immediate antibiotic treatment after E. coli inoculation, and in turn determined which of the maintenance of pregnancy with antibiotic and tocolytic administration or prompt delivery in the management of preterm labor complicated with intrauterine infection offered the improvement of pregnancy outcome. METHODS: Timed-pregnant rabbits underwent hysteroscopy at 20-21 days of gestation(70%). Animals were inoculated with either E. coli(0.2 ml containing 10' cfu/ml) or saline, and administered ampicillin-sulbactam(100 mg/kg/day; Unasyn; Pfizer) in divided doses every 8 hours beginning 30 minutes after microbial inoculation until euthanasia with one of the following; 3 days(n 10), 5 days(n 8), or 7 days(n-8) after hysteroscopy. In the first study, which performed in animals with inoculation of E. coli, pregnancy outcome including fetal survival rate and results of microbial studies and placental pathology were compared among three groups. In second study, which performed in animals with inoculation with saline, pregnancy outcome were compared among three groups for the purpose of elucidating effects of antibiotic administration during inoculation-to-euthanasia interval on pregnancy outcome. RESULTS: Of rabbits inoculated with E. coli and receiving antibiotics immediately, the rate of fetal survival and positive intrauterine cultures in total and live fetuses decreased significantly, and the rate of placental inflammation in total and live fetuses increased significantly with time from intracervical inoculation with E. coli to euthanasia(p<0.05, respectively). Of rabbits inoculated with saline and receiving antibiotics immediately, the rates of fetal survival, positive intrauterine cultures in total and live fetuses, and placental inflammation in total and live fetuses have no difference with time from intracervical inoculation with saline to euthanasia. CONCLUSION: Fetal complications including fetal death could be induced in utero if persistent subclinical intrauterine infection was present in spite of earlier antibiotics administration initiated after inoculation of E, coli. Therefore, when treating with antibiotics in intrauterine infection, it is needed to observe and monitor the presence of persistent intrauterine infection, and if it is persistent, prompt delivery may be better than maintenance of pregnancy with antibiotic and tocolytic administration for the improvement of pregnancy outcome.
Animals
;
Anti-Bacterial Agents*
;
Euthanasia
;
Female
;
Fetal Death
;
Fetus
;
Hysteroscopy
;
Inflammation
;
Obstetric Labor, Premature
;
Pathology
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy*
;
Rabbits
;
Survival Rate
9.CT-Free Registration Method for Finding Accurate Orientation of Acetabular-Cup in Total Hip Replacement Surgery.
Byung hoon KOH ; Yong San YOON ; Choong Hee WON
Journal of Korean Orthopaedic Research Society 2003;6(1):7-13
PURPOSE: This paper is proposing an improved CT-free registration method which may provide us an accurate and reliable placement of acetabular cup without CT/MRI images. DESIGN AND METHODS: The proposed method employs a T-bar shaped gauge placed on the anatomical landmarks of the pelvis for the registration. The T-bar shaped gauge has its own LED markers and the position of the gauge is obtained through OPTOTRAK3020 system. These landmark points are the anterior superior iliac spines and the symphysis pubis defining anterior pelvic plane. Two subjects were tested to compare the landmark based registration and the proposed T-bar based registration. RESULTS: The measurement deviations of the pelvic obliquity in the frontal plane, tilt in the sagittal plane, and rotation in the transverse plane were 2.08, 1.41, and 2.51 degrees respectively in the point based registration. The T-bar based registration produced 40% smaller deviations(p<0.05): the pelvic obliquity in the frontal plane, tilt in the sagittal plane, and rotation in the transverse plane were 0.84, 0.81, and 1.17 degrees respectively in the T-bar based registration. There was no outlier exceeding 5 degrees in measurement deviation by the T-bar based registration while the outliers were found by the landmark based registration. CONCLUSIONS: We found that T-bar based CT free registration method is more reliable and accurate than the landmark based registration for the acetabular cup navigation. Also, the new method produced more precise registration(p<0.05). We are expecting some offset error of the new registration method due to the skin thickness existing between the T-bar frame and the bony pelvic frame, which may be compensated if we may accumulate sufficient database of the offset.
Acetabulum
;
Arthroplasty, Replacement, Hip*
;
Pelvis
;
Skin
;
Spine
10.Additional Comments on 'Clinical Trial to Evaluate the Efficacy and Safety of a Home-use Intense Pulsed Light Device for Hair Removal, Treatment of Acne and Pigmentation Disorders, and Fine Wrinkle Reduction'.
Seonguk MIN ; Hyuck Hoon KWON ; Seon Yong PARK ; Ji Young YOON ; Dae Hun SUH
Korean Journal of Dermatology 2015;53(1):88-88
No abstract available.
Acne Vulgaris*
;
Hair Removal*
;
Pigmentation Disorders*