An experiment on seminal vesiculitis in rats induced by repeated injections of homologous and heterologous seminal vesicle tissue suspension with Freund's complete adjuvant was accomplished to produce an immune disease in the seminal vesicle for the purpose to find the cause of same type of lesion in human beings were divided into 7 In this study 65 healthy adult white rats which weighed from 150 to 250 gm. were divided into 7 groups are follows: Group 1. Six rats, control, injected with normal saline Group 2. Six rats, injected with adjuvant Group 3. Seven rats, injected with seminal vesicle tissue suspension Group 4. Six rats, injected with rat seminal vesicle tissue suspension and adjuvant with prednisolone Group 5. Seven rats, injected with rabbit seminal vesicle tissue suspension Group 6. Seven rats, injected with rabbit seminal vesicle tissue suspension with adjuvant. Rats in these 6 groups were injected weekly for 8 weeks and sacrificed on the sixty fourth day. Group 7. Twenty-six rate, rat seminal vesicle tissue suspension with adjuvant. Rats in this group were subdivided into four groups Group A. Five rats, injected 4 times and sacrificed on 64th day. Group B. Seven rats, injected 6 times and sacrificed on 64th day. Group C. Seven rats, injected 8 times and sacrificed on 64th day. Group D. Seven rats. injected 8 times and sacrificed on 92nd day. Seminal vesicles from all the rats sacrificed were histopathologically studied and results were obtained as follows. Significant histopathologic alterations suck as glandular atrophy, decreased secretoryactivity, interstitial fibrosis, edema. congestion and inflammatory cellinfiltration suggesting of noninfectious chronic seminal vesiculitis were obtained in most rats of Group 7. Severity of inflammatory reaction seemed to be accentuated according to the increase of frequency of the date of sacrifice not concerned. Those allergic reaction were appeared to be inhibited by administration of prednisolone.
Adult ; Animals ; Atrophy ; Edema ; Estrogens, Conjugated (USP) ; Fibrosis ; Humans ; Hypersensitivity ; Immune System Diseases ; Prednisolone ; Rats ; Seminal Vesicles*

Two hundred and sixty-three patients over the age of 50 years who visited our clinic during 6 and a half years from April 1954 to September 1960 were clinically investigated for the initial study of the benign prostatic hypertrophy in Korea. Among these 263 cases 36 were diagnosed as the benign prostatic hypertrophy and 19 of them were hospitalized. Their ages ranged from 51 to 82 years. The average was 68 years. Their chief complaints were reasonable for B. P. H. and urinary symptoms appeared more commonly than those of non B. P. H. group. Eighty-eight and 0.6% of their prostates appeared to be more or less enlarged in size. None of them were considered to stay within normal limits. Residual urine was noted from 3-1,500 cc in 31 checked cases, the average 62cc. Their urethras were intact in 83% of the cases. Their endoscopic findings were corresponding to the signs suggesting prostatic hypertrophy, mainly prostatic compression sign to the bladder, elongation of the prostatic urethra, kissing or almost kissing of the lateral lobes, trabeculation and cellule formations in the bladder and inflammatory signs of the bladder. Treatments given to 19 hospitalized cases included 10 suprapubic prostatectomy, 1 transurethral resection, 1 suprapubic cystostomy, and conservative treatments for the remainders. In all the patients who had received the surgical interventions, smooth and voluntary urination was restored as of discharge. No follow-up study was fulfilled. Weight of the removed prostates were noted from 39.5 gm to 107gm, the average 61.3gm. By a transurethral resection 10.2gm of hypertrophied prostate was resected. Of complications of 19 hospitalized cases. cystitis was found as a top 68.4%. Not only urological diseases, bladder stones, epididymitis and diverticula of the bladder but also systemic diseases, hypertensive heart disease, asthma and arteriosclerosis were found though less frequent.
Arteriosclerosis ; Asthma ; Cystitis ; Cystostomy ; Diverticulum ; Epididymitis ; Heart Diseases ; Humans ; Korea ; Male ; Prostate ; Prostatectomy ; Prostatic Hyperplasia* ; Urethra ; Urinary Bladder ; Urinary Bladder Calculi ; Urination ; Urologic Diseases

The relationship between the kidney and erythropoiesis was investigated. Thirty-three rabbits were used of which nine rabbits were subjected to bilateral nephrectomy, eight to unilateral nephrectomy with ureter ligation of the oppositekidney and nine to bilateral ureter ligation. The controls consisted of four rabbits. In each group, N.P.N., B.U.N., creatinine, normoblast count and half time of plasma iron disappearance(Fe59) were measured 72 hours after the operation and the following data were obtained. Normal group:N.P.N.,27.9mg%(18.5-36.0mg%), B.U.N.,17.2mg%(9.9-30.4mg%), creatinine, 1.3mg%(0.7-1.62mg%)normoblast, 28%(13-36%) and half time of plasma iron disappearance, 62min(40-92min) Bilaterally nephrectomized group: N.P.N.,262.1mg%(198.0-267.3mg%), B.U.N.,141.2mg%(130.5-146.0mg%), creatinine, 19.1mg%(9.45-19.47mg%) ,normoblast ,22% (1.0-5.0%)and half time of plasma iron disappearance, 139.8min(87-196min) Uinlateral nephrectomized group with ureter ligation of the opposite kidney: N.P.N.,256.2mg%(199.8-420.0mg%), B.U.N.,108.0mg%(90.0-112.5mg%) ,creatinine, 17.4mg%(12.4-18.7mg%),normoblast, 14.2% (8.0-26.0%) and half time of plasma irondisappearance, 86.0min(51.0-159.0min) Bilaterally ureter ligated group: N.P.N.,242.7mg%(236.4-333.0mg%), B.U.N.,135.5mg% (129.0-151.3mg%) ,creatinine, 19.8mg%(18.9-21.3mg%), normoblast, 18.2% (13.0-20.0%) and half time of plasma iron disappearance, 69.5min(49.0-92.0min) Normoblast markedly decreased(to 2.2%) and half time of plasma iron disappearance(Fe59) was strikingly higher(87 to 196 min., mean 139,8min.)than normal rabbits(40 to 92 min., mean 62 min.) in bilateral nephrectomized group. This marked depression of erythropoiesis occurred in bilateral nephrectomized group while in the group of bilateral ureterligation and unilateral nephrectomy with ureter ligation of opposite kidney only moderate depression of erythropoiesis was noted despite the elevation in azotemia and the degree of malnutrition were almost same level in these three groups. It suggests that the kidney is probably the source of and erythropoietic factor.
Azotemia ; Creatinine ; Depression ; Erythroblasts ; Erythropoiesis* ; Iron ; Kidney* ; Ligation ; Malnutrition ; Nephrectomy ; Plasma ; Rabbits* ; Ureter