Holt-Oram Syndrome is an autosomal dominant disorder characterized by the association of upper-limb abnormalities and congenital heart disease. A woman with no family history of genetic disease underwent antenatal sonography at 27 weeks' menstrual age to screen for fetal anomalies. Ultrasonography revealed abnormalities in the upper limbs. The limb abnormalities included abscence of bilateral thumbs and radius: the left humus was short. Pregnancy termination was performed. The postnatal chromosomal analysis revealed a normal 46XX karyotype and the autopsy finding confirmed the Holt-Oram syndrome. We report a case of Holt-Oram Syndrome in fetus with unaffected parents with brief of the literatures.
Autopsy ; Extremities ; Female ; Fetus ; Heart Defects, Congenital ; Humans ; Karyotype ; Parents* ; Pregnancy ; Radius ; Soil ; Thumb ; Ultrasonography* ; Upper Extremity

PURPOSE: The aim of this study was to evaluate the influence of the crown-to-implant (C/I) ratio on the change in marginal bone level around the implant and to determine the site-related factors influencing the relationship between the C/I ratio and periimplant marginal bone loss. METHODS: A total of 259 implants from 175 patients were evaluated at a mean follow-up of five years. Implants were divided into two groups according to their C/I ratios: < or =1, and >1. Site-related factors having an influence on the relationship between C/I ratio and periimplant marginal bone loss were analyzed according to the implant location, implant diameter, implant manufacturer, prosthesis type, and guided bone regeneration (GBR) procedure. RESULTS: It was found that 1) implants with a C/I ratio below 1 exhibited greater periimplant marginal bone loss than implants with a C/I ratio more than 1, 2) site-related factors had an effect on periimplant marginal bone loss, except for the implant system used, 3) the C/I ratio was the factor having more dominant influence on periimplant marginal bone loss, compared with implant diameter, prosthesis type, implant location, and GBR procedure, 4) implants with a C/I ratio below 1 showed greater periimplant marginal bone loss than implants with a C/I ratio greater than 1 in the maxilla, but not in the mandible, 5) and periimplant marginal bone loss was more affected by the implant system than the C/I ratio. CONCLUSIONS: Within the limitations of this study, implants with a higher C/I ratio exhibited less marginal bone loss than implants with a lower C/I ratio in the posterior regions. The C/I ratio was a more dominant factor affecting periimplant marginal bone loss in the maxilla than the mandible. Meanwhile, the implant system was a more dominant factor influencing periimplant marginal bone loss than the C/I ratio.
Alveolar Bone Loss ; Bone Regeneration ; Dental Implants ; Follow-Up Studies ; Humans ; Mandible ; Maxilla ; Prostheses and Implants ; Retrospective Studies

PURPOSE: The purpose of this study was to analyze the expression of inducible nitric oxide synthases (iNOS), tissue inhibitors of metalloproteinase (TIMP)-3, and TIMP-4 in the gingival tissues of periodontal patients with or without type 2 diabetes mellitus (DM). METHODS: Depending on the patient's systemic condition and clinical criteria of the gingiva, each gingival sample was classified into one of three groups. Sixteen clinically, systemically healthy patients (group 1), 16 periodontal patients (group 2), and 16 periodontal patients with DM (group 3) were included. Tissue samples in each group were collected, prepared, and analyzed by western blotting. Quantification of the relative amount of TIMP-3, TIMP-4, and iNOS was performed. RESULTS: The expression levels of iNOS and TIMP-3 both increased in group 1, group 2, and group 3 in increasing order, and were significantly higher in both group 2 and group 3 as compared to group 1 (P<0.05). The expression levels of TIMP-4 increased in the same order, but significantly increased in group 2 as compared to group 1, in group 3 as compared to group 1, and group 3 as compared to group 2 (P<0.05). CONCLUSIONS: This study demonstrated that iNOS, TIMP-3, and TIMP-4 might be involved in the progression of periodontal inflammation associated with type 2 DM. It is thought that further study of these factors can be applied practically for the diagnosis and control of periodontitis in diabetics.
Blotting, Western ; Chronic Periodontitis ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 ; Gingiva ; Humans ; Inflammation ; Nitric Oxide ; Nitric Oxide Synthase ; Periodontitis ; Tissue Inhibitor of Metalloproteinase-3 ; Tissue Inhibitor of Metalloproteinases

PURPOSE: We evaluated the abdominal uttrasonographic findings of Salmonellosis. MATERIALS AND METHODS: This study included 64 patients who were confirmed as salmonellosis by blood culture. We retrospectively analyzed the abdominal ultrasonographic findings with particular attention to enlarged mesenteric lymph nodes(mesenteric lymphadenitis), thickening of bowel wall, especially terminal ileum and cecum(ileocecitis), hepatosplenomegaly, ascites, gallbladder wall thickening, and enlarged lymph nodes in porta hepatis. RESULTS: The 64 cases were observed as mesenteric lymph node enlargement(44 cases), wall thickening of the terminal ileum and cecum(36 cases), hepatomegaly and/or splenomegaly(42 cases), minimal ascites(8 cases), gallbladder wall thickening(6 cases), and enlarged lymph nodes in porta hepatis(4 cases). No abnormal finding was seen in 10 patients. CONCLUSION: The mesenteric lymph node enlargement, wall thickening of the terminal ileum and cecum, hepatomegaly and/or splenomegaly, minimal ascites, gallbladder wall thickening, and enlarged lymph nodes in porta hepatis are suggestive findings of salmonellosis on abdominal ultrasonography in patients with fever and acute abdomen.
Abdomen, Acute ; Ascites ; Cecum ; Fever ; Gallbladder ; Hepatomegaly ; Humans ; Ileum ; Lymph Nodes ; Retrospective Studies ; Salmonella Infections* ; Splenomegaly ; Ultrasonography

PURPOSE: The purpose of the current study was to examine the effect of dexamethasone (Dex) at various concentrations on the apoptosis and mineralization of human periodontal ligament (hPDL) cells. METHODS: hPDL cells were obtained from the mid-third of premolars extracted for orthodontic reasons, and a primary culture of hPDL cells was prepared using an explant technique. Groups of cells were divided according to the concentration of Dex (0, 1, 10, 100, and 1,000 nM). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for evaluation of cellular viability, and alkaline phosphatase activity was examined for osteogenic differentiation of hPDL cells. Alizarin Red S staining was performed for observation of mineralization, and real-time polymerase chain reaction was performed for the evaluation of related genes. RESULTS: Increasing the Dex concentration was found to reduce cellular viability, with an increase in alkaline phosphatase activity and mineralization. Within the range of Dex concentrations tested in this study, 100 nM of Dex was found to promote the most vigorous differentiation and mineralization of hPDL cells. Dex-induced osteogenic differentiation and mineralization was accompanied by an increase in the level of osteogenic and apoptosis-related genes and a reduction in the level of antiapoptotic genes. The decrease in hPDL cellular viability by glucocorticoid may be explained in part by the increased prevalence of cell apoptosis, as demonstrated by BAX expression and decreased expression of the antiapoptotic gene, Bcl-2. CONCLUSIONS: An increase in hPDL cell differentiation rather than cellular viability at an early stage is likely to be a key factor in glucocorticoid induced mineralization. In addition, apoptosis might play an important role in Dex-induced tissue regeneration; however, further study is needed for investigation of the precise mechanism.
Alkaline Phosphatase ; Anthraquinones ; Apoptosis ; Bicuspid ; Cell Differentiation ; Cell Survival ; Dexamethasone ; Durapatite ; Humans ; Periodontal Ligament ; Prevalence ; Real-Time Polymerase Chain Reaction ; Tetrazolium Salts ; Thiazoles

No abstract available.
Cell Proliferation* ; Interleukin-1* ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive*

The study was conducted to examine the prevalence and degree of peri-implantitis in implant-supported bridges compared to splinted crowns in 3-unit and 4-unit posterior edentulous areas. A total of 229 implant sites from 79 patients who had received implants at the Kyungpook National University Dental Hospital were evaluated. The observation period ranged from 2 to 12 years. Patient characteristics and implant-related factors were investigated. After surgery and prosthetic treatment, radiographic evaluations were performed. Also, to identify factors that could affect the prognosis of the implants, Fisher’s exact tests and chi-square were used. In addition, the mean distance between crestal bone levels and implant platform was compared between implant-supported bridges and splinted crowns using the Mann-Whitney U test. No statistically significant differences were found in the mean distances between implant platforms and bone levels in either restoration type. The prevalence of peri-implantitis was 15% in splinted crowns and 13% in bridges, with restoration type showing no significant association. However, middle implant showed the highest rate of peri-implantitis compared to other positions. Furthermore, bone augmentation and implant sites (maxilla or mandible) showed significant association with peri-implantitis. In conclusion, restoration type does not influence the prevalence or severity of peri-implantitis, but implant position affect the rate of peri-implantitis. Clinicians should consider bone quality when choosing between implant-supported bridges and splinted crowns.

The study was conducted to examine the prevalence and degree of peri-implantitis in implant-supported bridges compared to splinted crowns in 3-unit and 4-unit posterior edentulous areas. A total of 229 implant sites from 79 patients who had received implants at the Kyungpook National University Dental Hospital were evaluated. The observation period ranged from 2 to 12 years. Patient characteristics and implant-related factors were investigated. After surgery and prosthetic treatment, radiographic evaluations were performed. Also, to identify factors that could affect the prognosis of the implants, Fisher’s exact tests and chi-square were used. In addition, the mean distance between crestal bone levels and implant platform was compared between implant-supported bridges and splinted crowns using the Mann-Whitney U test. No statistically significant differences were found in the mean distances between implant platforms and bone levels in either restoration type. The prevalence of peri-implantitis was 15% in splinted crowns and 13% in bridges, with restoration type showing no significant association. However, middle implant showed the highest rate of peri-implantitis compared to other positions. Furthermore, bone augmentation and implant sites (maxilla or mandible) showed significant association with peri-implantitis. In conclusion, restoration type does not influence the prevalence or severity of peri-implantitis, but implant position affect the rate of peri-implantitis. Clinicians should consider bone quality when choosing between implant-supported bridges and splinted crowns.

The study was conducted to examine the prevalence and degree of peri-implantitis in implant-supported bridges compared to splinted crowns in 3-unit and 4-unit posterior edentulous areas. A total of 229 implant sites from 79 patients who had received implants at the Kyungpook National University Dental Hospital were evaluated. The observation period ranged from 2 to 12 years. Patient characteristics and implant-related factors were investigated. After surgery and prosthetic treatment, radiographic evaluations were performed. Also, to identify factors that could affect the prognosis of the implants, Fisher’s exact tests and chi-square were used. In addition, the mean distance between crestal bone levels and implant platform was compared between implant-supported bridges and splinted crowns using the Mann-Whitney U test. No statistically significant differences were found in the mean distances between implant platforms and bone levels in either restoration type. The prevalence of peri-implantitis was 15% in splinted crowns and 13% in bridges, with restoration type showing no significant association. However, middle implant showed the highest rate of peri-implantitis compared to other positions. Furthermore, bone augmentation and implant sites (maxilla or mandible) showed significant association with peri-implantitis. In conclusion, restoration type does not influence the prevalence or severity of peri-implantitis, but implant position affect the rate of peri-implantitis. Clinicians should consider bone quality when choosing between implant-supported bridges and splinted crowns.

The study was conducted to examine the prevalence and degree of peri-implantitis in implant-supported bridges compared to splinted crowns in 3-unit and 4-unit posterior edentulous areas. A total of 229 implant sites from 79 patients who had received implants at the Kyungpook National University Dental Hospital were evaluated. The observation period ranged from 2 to 12 years. Patient characteristics and implant-related factors were investigated. After surgery and prosthetic treatment, radiographic evaluations were performed. Also, to identify factors that could affect the prognosis of the implants, Fisher’s exact tests and chi-square were used. In addition, the mean distance between crestal bone levels and implant platform was compared between implant-supported bridges and splinted crowns using the Mann-Whitney U test. No statistically significant differences were found in the mean distances between implant platforms and bone levels in either restoration type. The prevalence of peri-implantitis was 15% in splinted crowns and 13% in bridges, with restoration type showing no significant association. However, middle implant showed the highest rate of peri-implantitis compared to other positions. Furthermore, bone augmentation and implant sites (maxilla or mandible) showed significant association with peri-implantitis. In conclusion, restoration type does not influence the prevalence or severity of peri-implantitis, but implant position affect the rate of peri-implantitis. Clinicians should consider bone quality when choosing between implant-supported bridges and splinted crowns.