1.The actual status of patients with spinal injuries by industrial accidents.
Korean Journal of Occupational and Environmental Medicine 1991;3(1):32-42
No abstract available.
Accidents, Occupational*
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Humans
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Spinal Injuries*
2.Clinical significance of nontuberculous mycobacteria isolated from respiratory specimens.
Won Jung KOH ; O Jung KWON ; Hyoung Suk HAM ; Gee Young SUH ; Man Pyo CHUNG ; Ho Joong KIM ; Daehee HAN ; Tae Sung KIM ; Kyung Soo LEE ; Nam Yong LEE ; Eun Mi PARK ; Young Kil PARK ; Gill Han BAI
Korean Journal of Medicine 2003;65(1):10-21
BACKGROUND: We studied the clinical significance of nontuberculous mycobacteria (NTM) recovered from respiratory specimens for six months in a tertiary referral center. METHODS: We identified all NTM isolates from sputum or bronchial washing from October, 2001 to March, 2002, using polymerase chain reaction-restriction fragment length polymorphism analysis method amplifying the rpoB gene. Patients were classified as having definite, probable, or unlikely NTM disease as defined by the American Thoracic Society and the British Thoracic Society guidelines. RESULTS: 261 isolates of NTM recovered from 162 patients. In 162 patients, M. avium complex (MAC) was the most common species comprising 29.6% (n=48), which was followed by M. fortuitum complex (n=46, 28.4%), M. abscessus (n=26, 16.0%). 29 (17.9%) patients had definite NTM disease, and 13 (8.0%) had probable NTM disease. The common organisms involved in NTM diseases were MAC (n=23, 54.8%), M. abscessus (n=12, 28.6%). In a univariate analysis, predictive factors that were related to NTM disease were BMI <18.5 kg/m2, presence of symptoms, previous history of antituberculous treatment, positive sputum smear, presence of infiltrative, nodular or cavitary lesions at chest radiography, and isolation of MAC or M. abscessus. In a multivariate analysis, isolation of MAC or M. abscessus (OR 16.3, 95% CI 4.2~62.7, p<0.001), cavity at chest radiography (OR 4.8, 95% CI 1.4~16.6, p=0.012), and positive sputum smear (OR 4.3, 95% CI 1.4~13.3, p=0.012) were found to be variables independently associated with pulmonary disease. CONCLSUION: Epidemiology of NTM pulmonary disease in Korea is different from that in other countries. A high index of clinical suspicion as well as an accurate identification of the isolates would be required for the diagnosis of NTM pulmonary disease.
Diagnosis
;
Epidemiology
;
Humans
;
Korea
;
Lung Diseases
;
Multivariate Analysis
;
Mycobacterium avium Complex
;
Mycobacterium chelonae
;
Nontuberculous Mycobacteria*
;
Radiography
;
Sputum
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Tertiary Care Centers
;
Thorax
3.A Case Report of Three Patients with Nontuberculous Mycobacterial Pulmonary Disease Caused by Mycobacterium kansasii.
Won Jung KOH ; O Jung KWON ; Gee Young SUH ; Man Pyo CHUNG ; Hojoong KIM ; Nam Yong LEE ; Tae Sung KIM ; Kyung Soo LEE ; Eun Mi PARK ; Young Kil PARK ; Gill Han BAI
Tuberculosis and Respiratory Diseases 2003;54(4):459-466
Mycobacterium kansasii is the second most common cause of nontuberculous mycobacterial pulmonary disease in Western countries and Japan. The clinical and radiological features of pulmonary disease caused by M. kansasii usually resemble those of pulmonary tuberculosis including cavitary infiltrates with an upper lobe predilection. It is also now apparent that patients with M. kansasii pulmonary disease can present with noncavitary nodular bronchiectatic infiltrates similar to lung diseases of M.avium complex. With rifampin-containing regimens, treatment success rates are almost 100%. Timely diagnosis before the development of extensive disease and effective overall treatment strategies are very important to ensure that patients receive the appropriate medications for a sufficiently long period of time. To our knowledge, there has been no Korean case report of M. kansasii pulmonary disease in the immunocompetent patient until now. We report three cases of M. kansasii pulmonary disease in immunocompetent adult patients.
Adult
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Diagnosis
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Humans
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Japan
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Korea
;
Lung Diseases*
;
Mycobacterium kansasii*
;
Mycobacterium*
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Nontuberculous Mycobacteria
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Tuberculosis, Pulmonary
4.Treatment of Mycobacterium avium Complex (MAC) Pulmonary Disease.
Won Jung KOH ; O Jung KWON ; Eun Hae KANG ; Gee Young SUH ; Man Pyo CHUNG ; Hojoong KIM ; Myung Jin CHUNG ; Tae Sung KIM ; Kyung Soo LEE ; Nam Yong LEE ; Young Kil PARK ; Gill Han BAI
Tuberculosis and Respiratory Diseases 2004;57(3):234-241
BACKGROUND: There has been a gradual increase in the number of newly diagnosed cases of Mycobacterium avium complex (MAC) pulmonary disease. However, the optimal therapeutic regimen for the disease has not yet established and there is no report about the treatment outcome of MAC pulmonary disease in Korea. This study examined the effect of clarithromycin-based regimen in patients with pulmonary MAC disease without a HIV infection. MATERIALS AND METHODS: Fifty-six patients with pulmonary MAC disease were diagnosed according to the American Thoracic Society criteria from January 2000 to December 2003 at this hospital. Of these patients, 15 were treated with clarithromycin, rifampin, and ethambutol for more than 6 months, together with streptomycin initially (first 6 months) in 8 patients. RESULTS: Six months after the treatment, the sputum cultures converted from positive to negative in 8 patients (53%) and the radiological findings improved in 10 (67%). At 12 months 4 patients (44%) achieved sputum negative conversion and 6 patients out of 9 patients (67%) who were treated for more than 12 months showed radiological improvement. Overall, the sputum findings converted to negative in nine patients (60%) who underwent medical treatment. A pulmonary resection was successfully performed in one patient. Only one patient discontinued the treatment due to side effects such as gastrointestinal intolerance and optic neuritis. CONCLUSION: A combined regimen containing clarithromycin is relatively safe and tolerable even in the elderly outpatients. However, the results of this combined chemotherapy were unsatisfactory and new companion drugs for MAC pulmonary disease are needed. A resection may be considered for localized disease.
Aged
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Clarithromycin
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Drug Therapy
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Ethambutol
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Friends
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HIV Infections
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Humans
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Korea
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Lung Diseases*
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Mycobacterium avium Complex*
;
Mycobacterium avium*
;
Mycobacterium*
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Nontuberculous Mycobacteria
;
Optic Neuritis
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Outpatients
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Rifampin
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Sputum
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Streptomycin
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Treatment Outcome