No abstract available.
Chromatin* ; Humans* ; Population Characteristics* ; Sperm-Ovum Interactions* ; Spermatozoa*

Lyme disease is an infecious disease caused by Borrelia burgdorfieii and has been reported world-wide. The spirochete invades multiple organs and induces manifesations in the skin, joints, neri us and cardiovascular systems. 13espite a considerable amount of serological evidence and isolation of R burgdorferi in ticks, no human case has yet been reported in korea. In this report, we present the first clinical case of Lyme disease in Korea. A female patient, 26 years old, developed clinical signs of eryth m,i chronicum migpans about ten days after traveling to a rural area and responded well to treatment ith entibiotions. Laboratory tests showed elevated IgM and IgG responses to B. burgdorferi, and a spirociete was found in a skin biopsy by electron microscopy.
Adult ; Biopsy ; Borrelia ; Borrelia burgdorferi ; Cardiovascular System ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Joints ; Korea ; Lyme Disease* ; Microscopy, Electron ; Skin ; Spirochaetales ; Ticks

No abstract available.
Fertilization in Vitro* ; Fertilization* ; Humans*

PURPOSE: This study was undertaken to evaluate the long term survival of pelvic chondrosarcomas, optimal reconstructive procedures and functional results. MATERIAL AND METHODS: We studied 14 primary and 3 secondary cases of pelvic chondrosarcomas. All patients had an internal pelvectomy. Resection types were the iliac wing in 4, periacetabular in 9, and there were 4 in the pubic area. Reconstructive types were: no reconstruction in 6, spacer and bone graft in 2, heat treated autogenous bone-total hip replacement arthroplasty (THRA) composite in 4, limited fusion in 2 and the remaining 3 patients had a saddle prosthesis. RESULTS: An actual and continuous disease free survival rate was 93/87% at 130 months. The overall functional score was 22.4. The score for four cases of iliac resection was 27.7, in nine cases of periacetabular it was 18.6, and in four cases of pubic lesion it was 25.5. Associated complications were dislocation of THRA in one case, two cases of infection, sciatic nerve palsy in one and one case of skin necrosis that was secondary to radiation. CONCLUSION: Chondrosarcoma of pelvis shows an excellent long term survival rate. Attempts at pseudoarthrosis rather than anatomical reconstruction in periacetabular resections with massive soft tissue damage may reduce complications and their functional results are acceptable.
Arthroplasty, Replacement, Hip ; Chondrosarcoma* ; Disease-Free Survival ; Dislocations ; Hot Temperature ; Humans ; Necrosis ; Pelvis* ; Prostheses and Implants ; Pseudarthrosis ; Sciatic Neuropathy ; Skin ; Survival Rate ; Transplants

No abstract available.
Animals ; Cricetinae* ; Humans ; Male* ; Ovum* ; Spermatozoa*

No abstract available.
Sperm-Ovum Interactions* ; Spermatozoa*

No abstract available.
Animals ; Cricetinae* ; Cryopreservation* ; Oocytes*

No abstract available.
Female ; Humans ; Infertility* ; Pregnancy*

No abstract available.
Animals ; Cricetinae* ; Humans* ; Oocytes*

BACKGROUND: Spontaneous basal activation that might be related to survival mechanism of tumor cells by allowing them to escape from apoptosis has been proven in some tumor cells, but it has not been evaluated in malignant melanoma tissue. OBJECTIVE: The purpose of this study was to evaluate basal activation of NF-κB using immunohistochemical analysis and demonstrate its clinical significance in cutaneous malignant melanoma tissue. MATERIALS AND METHODS: Twenty-five cases of acral lentiginous melanoma(ALM) from 20 patients were selected. Immunohistochemical analysis was performed to detect nuclear localization of classic NF-κB heterodimer, p50 and p65 in the formalin-fixed, paraffin-embedded tissues. RESULTS: In about 50% of cases, nuclear expression of NF-κB heterdimer, p50 and p65 was detected, 12(48%) and 13(52%) of 25 cases of ALM, respectively. However, the nuclear ex-pressing of p50 and p65 was not significant for tumor thickness or level of invasion in ALM. CONCLUSION: We demonstrated basal NF-κB activation in malignant melanoma, but we need to research further to demonstrate its clinical significance.
Apoptosis ; Humans ; Immunohistochemistry ; Melanoma* ; United Nations