No abstract available.
Dermatomyositis*

We reviewed five cases of Uterine leiomyomas, each with a conspicuously, yellow cut surface, among 198 consecutive cases of surgically removed uterine leiomyomas. Their gross findings were not significantly different from ordinary leiomyomas except for their pale to bright Yellowish cut surface. Microscopically, multiple small clusters of clear cells were widely scattered in otherwise hypercellular leiomyornas in 4 of the 5 cases. Of those, one case gave a positive reaction of Oil-Red O stain. Ultrastructurally, clear cells corresponded to the degenerating smooth muscle cells with intracytoplasmic lipid vacuoles. The rest of cells showed myofibers undergoing varying degrees of degeneration. Focal accumulation of foamy histiocytes was associated with carneous degeneration in one case. We conclude that the yellowish leiomyoma of the uterus seems, in part, to reflect accumulation of a lipid substance in degenerating hypercellular leiornyoma, or possibly collections of xanthoma cells in secondary degeneration.

OBJECTIVE: No medication currently available for the treatment of rheumatoid arthritis is universally effective, and all can produce adverse effects. It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. It is also reported that diterpenoid which is a partially purified product ectracted from Acanthopanax koreanum has an anti-inflammatory effect. We conducted this study whether diterpenoid extracted from Acanthopanax koreanum has a regressive effect of collagen induced arthritis in DBA/1 mice. METHODS: Four groups of DBA/1 mice were immunized by intradermal injection of 1mg/kg chicken type II collagen with complete Freund's adjuvant. Group II received 5mg/kg of diterpenoid extracted from Acanthopanax koreanum orally daily and Group III receive 5mg/kg of phenylpropranoids extracted from Acanthopanax koreanum orally daily. Group IV received 1mg/kg dexamathasone intraperitoneally twice weekly. Group I received no treatment. The prevalence of arthritis were assessed twice weekly. Seoum anti-collagen antibody was measured by ELISA. Stimulation index of caltured splenocytes were measured. Tumor necrosis factor-alpha and interleukin-10 levels in the supernatant of cultured splenocytes stimulated with Con. A were also measured by ELISA. RESULT: Collagen induced arthritis(CIA) started to develop 5 weeks after collagen injections. In diterpenoid treated group, CIA seemed to be regressed, but in phenylpropranoid group, regressive effect of artiritis was not observed. In dexamathasone treated group, both of suppression of CIA could be observed. Levels of anti-collagen antibodies were reduced in dexamethasone treated group, but not in both diterpenoid and phenylpropranoid group. No significant differences of splenic mononuclear cell SI among the groups was observed. There was an increased secretion of interleukin-10 in the supernatant of cultured splenocytes stimulated by Con A of the diterpenoid treated group. CONCLUSION: These findings showed that the diterpenoid extracted from Acanthopanax koreanum have an effect on supression of CIA.
Eleutherococcus* ; Animals ; Antibodies ; Arthritis* ; Arthritis, Rheumatoid ; Chickens ; Collagen Type II ; Collagen* ; Dexamethasone ; Enzyme-Linked Immunosorbent Assay ; Freund's Adjuvant ; Injections, Intradermal ; Interleukin-10 ; Mice* ; Prevalence ; Tumor Necrosis Factor-alpha

The condition of anomalous nerve root is rare. The authors are reporting a case of conjoined nerve root anomaly associated with lumbar disc herniation in a 36-year-old male who was transferred from another hospital. A standard hemilaminectomy with a discectomy had been performed under the disgnosis of the L4-5 lumbar disc herniation at the other hospital. However symptoms were not relieved. During a second surgery at our hospital, a L5-S1 conjoined nerve root was discovered after removal of the extradural hematoma at the previous laminectomy site, a medial facetctomy with a foraminotomy were carried out and the conjoined root was decompressed completely. The patient returned to work 2 months postoperatively with complete relief of symptoms.
Adult ; Diskectomy ; Foraminotomy ; Hematoma ; Humans ; Laminectomy ; Male

A retrospective study of operative results was carried out in a series of 48 patients who were performed automated percutaneous discectomy for herniated lumbar disc using Nucleotome between Jan. 1990 and Jan. 1994. The operative results were analysed, and the correlation between preoperative clinicoradiological factors and postoperative clinical results were statistically assessed. The major results were as follows: 1) Of 48 patients, 37 were males and 11 were females. Mean age of the patients was 31.7 years and the highest incidence occurred in their thirties. 2) The preoperative symptoms and signs were radiating pain(100%), lumbago(94%), motor weakness(21%), and positive score in straight leg raising test(77%). Mean duration of symptoms was 33.1 months and the duration of recent aggravation was 3.7 months. 3) Operation was performed in 62 intervertebral discs, the most commonly involved level was L4-5(53%). Mean duration of follow-up was 19.1 months. 4) Clinical results on follow-up were graded excellent in 65%, good in 21%, fair 8% and poor in 6% by Cagot's classification, and the overall success rate was 85% by Onik's classification. 5) As to age distribution and the group concerning compensatory and non-compensatory, success rates were not statistically significant. 6) The causes of failure were sequestered discs in 3 cases, suspicious sequestered discs in 2 cases, combined spinal stenosis with multiple discs in 1 case and worker's compensation in 1 case. According to the above results, automated percutaneous discectomy was recommended as primary choice of relatively noninvasive surgical procedure for the herniated lumbar discs except or sequestered disc and spinal stenosis.
Age Distribution ; Classification ; Diskectomy, Percutaneous* ; Female ; Follow-Up Studies ; Humans ; Incidence ; Intervertebral Disc ; Leg ; Magnetic Resonance Imaging ; Male ; Retrospective Studies ; Spinal Stenosis ; Workers' Compensation

This study aims to evaluate the changes of flavonoid contents and antioxidants activity of Jeju native citrus fruits juice according to the harvest date. Flavonoids such as quercatagetin, narirutin, hesperidin and neohesperidin were contained most plentifully in the juice of Jigak (Citrus aur- antium) by 573.73 mg/100 mL, Sadoogam (C. pseudogulgul) by 393.99 mg /100 mL, Soyooja by 29.63 mg/100 mL and Jigak (C. aurantium) by 201.23 mg/100 mL in the late August, respectively. The highest contents of nob-iletin, sinensetin and tangeretin among polymethoxyflavones were found in the juice of Hongkyool (C. tachibana) by 7.39 mg/100 mL, 2.24 mg/100 mL, 0.63 mg/100 mL in the late August, respectively. 3,5,6,7,8,3',4'- Heptamet- hoxyflavone recorded the highest amount in Punkyool (C. tangerina) by 0.27 mg/100 mL in the late August, but the other polymethoxyflavones including 3',4',7,8-tetramethoxyflavone, 3',4'-dimethoxyflavone, 4'-methoxyflavone, 5,6,7,3',4',5'-hexamethoxyflavone, scutellarein tetramethylether were observed only trace amount in all the citrus fruits. Flavonoid contents in the citrus fruit juices were the highest during early maturation and decreased rapidly while ripening. Total polyphenol contents were the highest in the late August and decreased with ripening. However from the late December, the contents were increased again. Antioxidant activities of the fruits were evaluated as electron donating ability and were the lowest in the late September and increased with the fruit ripening. These results suggest that quercetagetin among all the flavonoids was most plentiful in Jigak and Dangyooja (C. grandis), so that the fruits could be used for industrial material of flavonoids and antioxidant agents.
Antioxidants ; Apigenin ; Chromones ; Citrus ; Disaccharides ; Electrons ; Flavanones ; Flavones ; Flavonoids ; Fruit ; Hesperidin

Sarcomatoid urothelial carcinoma is a rare malignancy with a poor prognosis. We experienced a case of sarcomatoid urothelial carcinoma of the renal pelvis with extremely aggressive clinical behavior. An 81-year-old woman underwent a laparoscopic radical nephroureterectomy to remove a 4.5x3.1 cm sized localized left renal pelvis mass. The mass was pathologically confirmed as a sarcomatoid urothelial carcinoma. Although the operation was successful, the patient died 2 months postoperatively with widely metastatic disease.
Aged, 80 and over ; Female ; Humans ; Kidney Pelvis ; Prognosis

The authors present a case of non-mycotic aneurysm arising from the marginal branch of the left superior cerebellar artery(SCA) in a 65-year-old female. Cerebral angiography disclosed a saccular aneurysm(3x3 mm) at the origin of marginal branch of the left SCA. The aneurysm was successfully clipped through the infratentorial-supracerebellar approach. Since the aneurysm from the marginal branch of the SCA is rare, we reported here briefly.
Aged ; Aneurysm* ; Arteries* ; Cerebral Angiography ; Female ; Humans

Oncoplastic surgery has revolutionized the field of breast conserving surgery (BCS). The final aims of this technique are to obtain an adequate resection margin that will reduce the rate of local recurrence while simultaneously improving cosmetic outcomes. To obtain successful results after oncoplastic surgery, it is imperative that patients be risk-stratified based on risk factors associated with positive margins, that relevant imaging studies be reviewed, and that the confirmation of negative margins be confirmed during the initial operation. Patients who had small- to moderate-sized breasts are the most likely to be dissatisfied with the cosmetic outcome of surgery, even if the defect is small; therefore, oncoplastic surgery in this population is warranted. Reconstruction of the remaining breast tissue is divided into volume displacement and volume replacement techniques. The use of the various oncoplastic surgeries is based on tumor location and excised breast volume. If the excised volume is less than 100 g, the tumor location is used to determine which technique should be used, with the most commonly used technique being volume displacement. However, if the excised volume is greater than 100 g, the volume replacement method is generally used, and in cases where more than 150 g is excised, the latissimus dorsi myocutaneous flap may be used to obtain a pleasing cosmetic result. The local recurrence rate after oncoplastic surgery was lower than that of conventional BCS, as oncoplastic surgery reduced the rate of positive resection margins by resecting a wider section of glandular tissue. If the surgeon understands the advantages and disadvantages of oncoplastic surgery, and the multidisciplinary breast team is able to successfully collaborate, then the success rate of BCS with partial breast reconstruction can be increased while also yielding a cosmetically appealing outcome.
Breast ; Breast Neoplasms ; Cosmetics ; Displacement (Psychology) ; Female ; Humans ; Precision Medicine ; Mammaplasty ; Mastectomy, Segmental ; Recurrence ; Risk Factors

This paper describes a student-centered case study program concerning the tumor pathology course for first year students in medical school under the traditional curricular structure. A traditional, discipline-oriented, lecture-laboratory approach was partly modified by introducing a tutuorial session using a modified case matrix format during the laboratory hours without altering the general scheme of the existing system. Small group tutorial sessions were set with the development of learning objectives emphasizing clinicopathologic reasoning and early exposure to future practical presentation which was followed by the large class session; each tutorial was supplied with a short clinical history, gross kodachrome slides, and microslides. The session for problem identification was replaced by proving a series of instructor-designed questions for both pathology and interdisciplinary correlation during which pedagogical implication was stressed the most. Student's active participation, development of self learning skill and vigorous teaching-learning process among students, and motivation/relevance for forthcoming pathology study were among the benefits conferred by this modification. We conclude that this approach is an interim step to meet the advantages of problem-based learning even in a traditional curricular structure.