1.GnRH Agonist Co-treatment for Prevention of Primary Ovarian Insufficiency in Patients with Hematologic Malignancies Undergoing Chemotherapy.
Sungwook CHUN ; Yong Il JI ; Young Don JOO
The Journal of Korean Society of Menopause 2013;19(2):93-100
OBJECTIVES: The aim of this study was to assess the effect of gonadotropin-releasing hormone (GnRH) agonist co-treatment for gonadal protection in patients with hematologic neoplasms undergoing chemotherapy. METHODS: Young premenopausal women who were diagnosed with leukemia or lymphoma between March 2010 and February 2012 and undergoing chemotherapy in a university hospital were included in this study. RESULTS: Twenty-nine patients aged 15.39 years participated in this study. Among the patients, five patients were receiving leuprolide concomitant with chemotherapy, and twenty-four patients were receiving chemotherapy alone. Seventeen patients in the chemotherapy alone group stopped menstrating and were diagnosed with primary ovarian insufficiency (POI) within one year after chemotherapy; and only one patient had POI in the chemotherapy plus leuprolide group, but these differences were not statistically significant (P = 0.054). In the chemotherapy plus leuprolide group, serum anti-mullerian hormone (AMH) levels were significantly lower than basal serum AMH levels (5.57 +/- 0.18 ng/mL) (P < 0.001) after treatment (1.84 +/- 0.22 ng/mL). CONCLUSION: GnRH agonist may be a promising option for the prevention of POF, but the effectiveness of GnRH agonist is still debatable. A large prospective multi-center trial with adequate follow-up is needed.
Aged
;
Anti-Mullerian Hormone
;
Female
;
Gonadotropin-Releasing Hormone
;
Gonads
;
Hematologic Neoplasms
;
Humans
;
Leukemia
;
Leuprolide
;
Lymphoma
;
Primary Ovarian Insufficiency
2.Usefulness of Autofluorescence Imaging for Estimating the Extent of Gastric Neoplastic Lesions: A Prospective Multicenter Study.
Jun Haeng LEE ; Joo Yong CHO ; Myung Gyu CHOI ; Joo Sung KIM ; Kee Don CHOI ; Yong Chan LEE ; Jae Young JANG ; Hoon Jai CHUN ; Sang Yong SEOL
Gut and Liver 2008;2(3):174-179
BACKGROUND/AIMS: The aim of this study was to determine whether the margin of early to be detected gastric cancer (EGC) and gastric adenoma is easier to be detected with autofluorescence imaging (AFI) than with white-light endoscopy (WLE). METHODS: A total of 102 lesions (48 EGCs and 54 gastric adenomas) found in 98 patients were removed endoscopically or surgically. The measured length of each pathology specimen was compared with the lengths estimated using WLE, AFI, and chromoendoscopy. RESULTS: The lesions could be discriminated from surrounding mucosa by AFI in 86 cases (84.3%). The detection rates were similar for elevated lesions (85.1%) and flat/depressed lesions (82.9%, p=0.770). In terms of histology, the detection rate was slightly higher for adenomas (90.7%) than for cancer (77.1%, p=0.058). The estimated length was shorter than the pathologic length in 31.4% of cases when using WLE and 22.1% of cases when using AFI (p=0.168). The resection range was larger for EMR than for AFI in 24 of 80 cases (30.0%). CONCLUSIONS: WLE tends to underestimate the size of EGCs, whereas AFI tends to overestimate their size.
Adenoma
;
Endoscopy
;
Fluorescence
;
Humans
;
Mucous Membrane
;
Optical Imaging
;
Prospective Studies
;
Stomach Neoplasms
3.Extragenital Primary Syphilis Acquired by Scratching with the Fingernails.
Joo Yong HAN ; Myoung Don OH ; Sun Hee LEE ; Nam Joong KIM ; Chul Woo KIM ; Kang Won CHOE
Korean Journal of Infectious Diseases 2000;32(2):164-166
A 46-year-old woman was admitted with an ulcerative lesion on the posterior neck. Four months before admission, the patient took part in a faith healing ritual, which the pastor performed with his fingernails causing wounds. This abnormal method of healing caused repeated injury to the patient in the posterior neck area. Treatment with cefazolin was begun, but the lesion did not improve. Biopsy of the skin lesion and cervical lymph nodes was performed. Microscopical examination revealed findings highly suggestive of syphilis. Serological tests for syphilis were positive and a computed tomographic (CT) scan of the neck showed enlargement of regional lymph nodes and tonsils. A single dose of penicillin G 2.4 million units was given intramuscularly. Two weeks later, the wound had healed. Eight weeks after treatment, the Venereal Disease Research Laboratory titer had decreased and a CT scan of the neck showed a decrease in the size of the lymph nodes. We reasoned that syphilis was non-sexually transmitted, and that the healing ritual was the cause. Our case suggests that skin trauma by scratching with the fingernails may cause an accidental direct inoculation of Treponema pallidum, resulting in extragenital primary syphilis.
Biopsy
;
Cefazolin
;
Faith Healing
;
Female
;
Humans
;
Lymph Nodes
;
Middle Aged
;
Nails*
;
Neck
;
Palatine Tonsil
;
Penicillin G
;
Serologic Tests
;
Sexually Transmitted Diseases
;
Skin
;
Syphilis*
;
Tomography, X-Ray Computed
;
Treponema pallidum
;
Ulcer
;
Wounds and Injuries
4.A case report of peutz-jeghers syndrome causing ileocolic intussusception.
Cheong Yong KIM ; Youg Hwan KIM ; Hong Joon CHUN ; Suen Woo BACK ; Young Don MIN ; Chan Gook PARK ; Joo Nam BYUN
Journal of the Korean Society of Coloproctology 1993;9(1):77-82
No abstract available.
Intussusception*
;
Peutz-Jeghers Syndrome*
5.Juvenile Dermatomyositis Presenting as Deep Skin Ulcerations as an Initial Manifestation.
Sun Yong KWON ; Jin Kyung CHAE ; Sang Hyun PARK ; Joo Yeon KO ; Seok Don PARK ; Kun PARK
Korean Journal of Dermatology 2014;52(3):169-172
Juvenile dermatomyositis is a common idiopathic inflammatory myopathy in childhood and is characterized by symmetric proximal muscle weakness and specific cutaneous manifestations. We here report on a 12-year-old boy who presented with violaceous maculopatches with multiple deep skin ulcerations on the right arm and lower back 4 months ago. One month after the initial visit, he had difficulty climbing stairs and elevating his arms above the head. Laboratory tests showed elevation of the serum levels of skeletal muscle enzymes, and electromyogram and muscle biopsy indicated myopathy. Histopathological analysis of the ulceration indicated necrotizing vasculitis and calcification. Based on these findings, his condition was diagnosed as juvenile dermatomyositis. We believe that this case is unique because of the difficulty in diagnosing the condition, as skin ulceration is a rare cutaneous manifestation of dermatomyositis.
Arm
;
Biopsy
;
Child
;
Dermatomyositis*
;
Head
;
Humans
;
Male
;
Muscle Weakness
;
Muscle, Skeletal
;
Muscular Diseases
;
Myositis
;
Skin Ulcer*
;
Ulcer
;
Vasculitis
6.Severe Cholestatic Jaundice and Subsequent Pancytopenia Associated with Ticlopidine.
Hae Seong YOON ; Hyeong Kweon KIM ; Kwang Soo CHA ; Uk Don YOON ; Sam Yong JI ; Joo Ho KIM ; Shin Bae JOO ; Moo Hyun KIM ; Young Dae KIM ; Woo Weon SHIN ; Jong Seong KIM
Korean Circulation Journal 1999;29(11):1259-1263
No abstract available.
Jaundice, Obstructive*
;
Pancytopenia*
;
Ticlopidine*
7.A Case of Recurred Small Hepatocellular Carcinoma as a Solitary Lymph Node Metastasis after Hepatic Resection.
Joo Han LIM ; Jin Woo LEE ; Eun Joo KIM ; Jung Il LEE ; Seok JEONG ; Don Haeng LEE ; Yong Woon SHIN ; Joon Mee KIM
The Korean Journal of Gastroenterology 2007;50(1):66-69
Extrahepatic recurrence of hepatocellular carcinoma (HCC) has been considered unsuitable for surgical resection since the disease is considered to be extensive. However, solitary local lymph node recurrence in small HCC is rarely reported with suitable treatment modality being uncertain. We herein, present a case of 60-year-old female patient with small HCC showing late lymph node metastasis after complete resection of primary HCC. A 2 cm-sized hepatic mass was completely resected by segmentectomy (VIII). Eight months later, CT and PET scan revealed a 4.5 cm-sized portocaval lymph node (LN). In addition, whole body PET/CT scan strongly suggested a solitary tumor recurrence. Radical lymphadenectomy was performed. Tumor was confirmed as LN metastasis from HCC by excisional histopathological examination. Adjuvant chemotherapy and radiotherapy were followed.
Carcinoma, Hepatocellular/*pathology/surgery
;
Combined Modality Therapy
;
Female
;
Humans
;
Liver Neoplasms/*pathology/surgery
;
Lymph Node Excision
;
Lymphatic Metastasis
;
Middle Aged
;
Neoplasm Recurrence, Local/*pathology
;
Positron-Emission Tomography
;
Tomography, X-Ray Computed
8.A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis.
Jun Mo KIM ; Young Sig KIM ; Mee Kyung NAMGOONG ; Kwan Hyun PARK ; Yong Hoon PARK ; Sang Don LEE ; Seung Joo LEE ; Jae Yong CHUNG
Korean Journal of Urology 2008;49(2):168-173
PURPOSE: We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis(NE). MATERIALS AND METHODS: The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1(imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2(desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data. RESULTS: Mean wetting events in group 1 decreased from 8.8 to 5.1 times(2 weeks) and 3.0 times(4 weeks)(p=0.009) versus 10.2 to 5.5 times(2 weeks) and 6.4 times(4 weeks)(p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9(baseline), 4.4(2 weeks), and 3.7(4 weeks), and, for group 2, 5.1(baseline), 4.8(2 weeks), and 4.8(4 weeks). The two groups were not different(p=0.14, p=0.73). CONCLUSIONS: Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability.
Arousal
;
Child
;
Deamino Arginine Vasopressin
;
Humans
;
Imipramine
;
Korea
;
Nocturnal Enuresis
;
Prospective Studies
9.A Case of Angiocentric T-cell Lymphoma of the Esophagus.
Sung Kwon BAE ; Eun Sang KUWON ; Myung Sun JOO ; Woo CHOI ; Don Haeng LEE ; Pum Soo KIM ; Hyeon Geun CHO ; Yong Woon SHIN ; Young Soo KIM ; Tae Sook HWANG
Korean Journal of Gastrointestinal Endoscopy 1998;18(4):553-559
In this study we present a case of an angiocentric T-cell lymphoma (ACTL) which involve the esophagus. A 37-year-old male was admitted with dysphagia, odynophagia, and weight loss for 3 months. Two months before his admission, he had undergone on endoscopy with a biopsy. The first endoscopic findings revealed a large ulcerative lesion on the esophagus, although there had been no evidence of lymphoma upon microscopic examination. On the follow up endoscopic examination, this ulcerative lesion revealed progressive and destructive change. Histopathology of the third biopsied specimens showed large atypical lymphocyte infiltrates with angiocentric and angioinvasive features. Immunohistochemical studies revealed that the atypical (large) lymphocytes had T-cell phenotypes (CD3+, CD5+, and CD43+) and contained few reactive B-cells (CD20+), We assume that this is the first case of ACTL involving the esophagus and larynx.
Adult
;
B-Lymphocytes
;
Biopsy
;
Deglutition Disorders
;
Endoscopy
;
Esophagus*
;
Follow-Up Studies
;
Humans
;
Larynx
;
Lymphocytes
;
Lymphoma
;
Lymphoma, T-Cell*
;
Male
;
Phenotype
;
T-Lymphocytes*
;
Ulcer
;
Weight Loss
10.A case of anorexia Nervosa complicated by Pneumomediastinum and Retropneumoperitoneum.
Tae Hyup KIM ; Kee Don CHOI ; Min Kyung KIM ; Soon Joo KIM ; Ho June SONG ; Hwoon Yong JUNG ; Jin Ho KIM
Korean Journal of Medicine 2009;76(3):338-342
Since anorexia nervosa is a multi-systemic disorder, as well as a psychiatric disorder, it needs a multidisciplinary approach. It causes many medical problems, including irregular menstruation, hematologic problems, decreased bone density, electrolyte imbalance, and dysrhythmias. Sometimes, this disorder also causes rare, unexpected complications, including abnormal air collections, such as pneumomediastinum, retropneumoperitoneum, or subcutaneous emphysema. The cause of these phenomena is unknown, although fragile parenchymal tissue that is disrupted easily when the local pressure is increased by coughing, vomiting, or defecation is a suggested cause. We experienced a case of anorexia nervosa complicated with abnormal air collections. After we excluded other possible causes, such as perforation of the gastrointestinal tract, and ordered the patient to undergo a short fast and inhale oxygen, the abnormal air collections resolved. We report this case because of its rarity and benign course.
Anorexia
;
Anorexia Nervosa
;
Bone Density
;
Cough
;
Defecation
;
Female
;
Gastrointestinal Tract
;
Humans
;
Mediastinal Emphysema
;
Menstruation
;
Oxygen
;
Retropneumoperitoneum
;
Subcutaneous Emphysema
;
Vomiting