BACKGROUND AND AIMS: Ectopic pancreas in the stomach is a relatively uncommon abnormality. Although its typical finding on endoscopy was described as a submucosal nodule with central umbilication, it is still difficult to differenciate ectopic pancreas from other pathologies. So we investigated the endoscopic findings of ectopic pancreas in the stomach. METHODS: Between Jan. 1987 and Aug. 1998, nineteen patients who underwent gastroendoscopy and were histologically diagnosed as ectopic pancreas by various methods, were encountered at the Department of Internal Medicine, Severance Hospital, Yonsei University. The clinicopathologic records of all the patients were reviewed. RESULTS: The mean age of the patients was 39.3 years old with a male to female ratio of 1:2.8. Endoscopically, seventeen cases (89.5%) were suggestive of submucosal tumors. Submucosal tumors combined with umbilication were in 4 cases (21.1%), with ulceration in 2 cases (10.5%), erosion in 5 cases (26.3%), ulceration and erosion in 1 case (5.3%), and normal mucosa in 5 cases (26.3%) respectively. The size of ectopic pancreas was in the range of 0.8-3.0 cm, except in one case which measured 6.0 cm. The location of ectopic pancreas was in the antrum in 18 cases (94.7%), and in the angle in 1 case (5.3%). The endoscopic diagnoses were ectopic pancreas in 5 cases (26.3%), submucosal tumor in 12 cases (63.1%), gastric polyp in 2 cases (10.5%). The methods of histologic diagnosis of ectopic pancreas in 3 cases (15.8%) was by endoscopic biopsy, by endoscopic submucosal resection in 10 cases (52.6%), and by operation in 6 cases (31.6%). CONCLUSIONS: Ectopic pancreas in the stomach is found in various morphology, presented as submucosal tumors in the antrum. Because histological diagnosis by endoscopic forcep biopsy is difficult in many cases, endoscopic submucosal resection or operation should be considered.
Biopsy ; Diagnosis ; Endoscopy ; Female ; Humans ; Internal Medicine ; Male ; Mucous Membrane ; Pancreas* ; Pathology ; Polyps ; Stomach* ; Surgical Instruments ; Ulcer

The methylation of a 23-kDa nuclear protein increased after partial hepatectomy and methylation returned to basal levels after the initial stage of regeneration. The methylating enzyme was partially purified from rat liver by ammonium sulfate precipitation, DEAE-anion exchange chromatography and Butyl-Sepharose chromatography. The 23-kDa protein was purified from a nuclear fraction of liver tissue with SP-Sepharose. When the 23-kDa protein was methylated with the partially purified methyltransferase and analyzed on C18 high performance liquid chromatography (HPLC), the methylated acceptor amino acid was monomethyl lysine (MML). Previously, only arginine N-methylation of specific substrate proteins has been reported during liver regeneration. However, in this report, we found that lysine N-methylation increased during early hepatic regeneration, suggesting that lysine N-methylation of the 23-kDa nuclear protein may play a functional role in hepatic regeneration. The methyltransferase did not methylate other proteins such as histones, hnRNPA1, or cytochrome C, suggesting the enzyme is a 23-kDa nuclear protein- specific lysine N-methyltransferase.
Animals ; Cytochromes c/metabolism ; DNA Helicases/metabolism ; Hepatectomy ; Histone-Lysine N-Methyltransferase/*metabolism ; Histones/metabolism ; Liver ; Liver Regeneration/*physiology ; Lysine/*metabolism ; Methylation ; Proteins/*metabolism ; Rats ; Rats, Sprague-Dawley ; Research Support, Non-U.S. Gov't

To evaluate the effect and untoward reaction of "Isocal(Mead-Johnson B.V., Netherlands), lactose free polymeric enteral nutrient, 32 surgical or malnourished patients were selected. The nutritional parameters and indices after feeding of Isocal were compared to the pretreatment states. Routes of intake were oral(N=17) or nasoduodenal tube feeding(N=15). The average duration of treatment were 14.3 days(8 to 30 days). Among the 6 trial failures, 4 cases were directly related with Isocal feeding, such as intolerable diarrhea(N=3), and abdominal pain with partial ileus of recurrent stomach cancer(N=1). Transient diarrheas were in 3 cases. All of the cases with diarrhea were in oral feeding group. Nutritional parameters such as anthropometric scales and serum albumin showed progressive improving tendencies after Isocal, and transferrin(p=0.017) and total lymphocyte counts(TLC, p=0.057) in transitional feeding group revealed significant improvements. Nitrogen balance improved within the first week(p=0.000) of feeding. The Instant Nutritional Score(INS) of 9 cases got better, but 3 became worse, which includes 2 cases of terminal recurrent cancers. CPK revealed a significant drop(p=0.021) in one week. Blood chemical parameters didn't show any untoward changes during the periods. In conclusion, Isocal, via oral as well as nasoduodenal tube feeding, was an effective and useful enteral nutrient with acceptable side effects. Nasoduodenal tube feeding was preferable to avoid unwanted diarrhea. Transferrin, TLC, nitrogen balance, INS and CPK were reliable nutritional parameters even in two weeks' short period of clinical study.
Abdominal Pain ; Diarrhea ; Enteral Nutrition* ; Humans ; Ileus ; Lactose ; Lymphocytes ; Nitrogen ; Polymers ; Serum Albumin ; Stomach ; Transferrin ; Weights and Measures

The integrated cell culture-PCR (ICC-PCR) method has been suggested as an improved method for detection of viruses in water environments. We tested 57 source waters including finished water samples in Gyeonggi-do for enteric viral contamination using total culturable virus assay (TCVA) using BGMK cells and ICC-PCR. Nineteen of the 57 source water samples (33.3%) exhibited the cytopathic effect (CPE) on BGMK cells and no finished water did exhibited CPE. Nineteen samples (33.3%) of the 57 were positive for reoviruses. For the enteroviruses, only 3 samples (5.3%) of the 57 samples showed positive results. By using ICC-PCR method, 202 flasks from source water samples were positive for enteroviruses and reoviruses. Three samples from source water were positive for both viruses. However, any flasks tested was not co-infected with two types of viruses. While the enteric viral frequencies in TCVA and ICC-PCR were similar, the viral frequency for reoviruses at first passage in two type of method was higher in ICC-PCR (94.7%) than TCVA (56.9%).
Enterovirus ; Viruses ; Water