Albright's syndrome consists of large pigmented macules of the skin and fibrodysplasia of the bones. The full syndrome with precocious puberty occurs particularly in girls. Other endocrinopathies including Cushing syndrome, hyperthyroidism and acromegaly can be accompanied. A case of Albright's syndrome is reported. The patient was a 4-year-old male child, who was born with multiple, dark brownish, irregularly bordered macules on the trunk and extremities. Deformities of facial skeleton and limping gait were noticed at the age of 2 years. He had pathological fractures twice, at the age of 3 and 4 years, respectively, due to fibrodysplasia of both femur bones. Especially, involvement of the sphenoid bones caused compression of the optic nerves and diminished vision of both eyes. On radiologic examinations, polyostotic fibrous dysplasia were noticed on the humerus, scapula, femur, tibia, fibula, pelvis, vertebra and skull base. The level of alkaline phosphatase was highly elevated.
Acromegaly ; Alkaline Phosphatase ; Child ; Child, Preschool ; Congenital Abnormalities ; Cushing Syndrome ; Extremities ; Female ; Femur ; Fibrous Dysplasia, Polyostotic* ; Fibula ; Fractures, Spontaneous ; Gait ; Humans ; Humerus ; Hyperthyroidism ; Male ; Optic Nerve ; Pelvis ; Puberty, Precocious ; Scapula ; Skeleton ; Skin ; Skull Base ; Sphenoid Bone ; Spine ; Tibia ; Vision, Low

No abstract available.
Primary Health Care*

No abstract available.
Obesity*

Experimental and clinical observation on the effects of severing the mesentery in sigmoidocystoplasty was presented with the following results. Preceded by experimental study on 8 dogs,3 clinical cases of severe hyperchloremic acidosis after bladder reconstruction following sigmoidocystoplasty and undergone severing of the mesentery of the graft at 10.11 and 34 months respectively. As far as can be assessed after such short of post-operative observations, certain common features can be ascertained and the following conclusion drawn: 1)Severing of the mesentery to the intestinal segment 60 days after sigmoidocystoplasty yields no ill effect and no mortality. The post-operative course was uneventful and no sign of necrosis or peritonitis has been demonstrated. 2)Hyperchloremic acidosis and hypopotassemia after the bladder reconstruction were promptly corrected after this procedure, and clearly demonstrated in 3 clinical cases of severe hyperchloremic acidosis with hypopotassemia. 3)Mucus secretion in the reconstructed bladder disappeared almost completely 3 months after severing the mesentery. 4)Reabsorption of the radioisotope Na 24 from the artificial bladder was considerably reduced by the procedure.
Acidosis ; Hypokalemia ; Mesentery* ; Mortality ; Necrosis ; Peritonitis ; Transplants ; Urinary Bladder

BACKGROUND: With the increasing numbers of foreign residents and tourists in Korea, the need of medical care systems for foreign patients seems to be growing, but there are few studies related with foreigners staying in Korea so far. This study was conducted to obtain the basic clinical data of foreign patients for the better medical care of them. METHODS: This study is an analysis of 1,405 outpatients in International(Foreign) Clinic of Kangbuk Samsung Hospital from Jan. 1 1994 to Dec. 31 1996. Patient charts were reviewed and analyzed. RESULTS: Of the total of 1,405 cases, 833 cases(59.3%) were males and 572 cases(40.7%) were females. The largest age group was the 4th decades, which were 408 cases(29.0%). By racial grouping, Japanese were the largest, accounting for 507 cases(36.1%) of all, followed by Europeans(including Oceanians) with 384 cases(27.3%) and North Americans with 335 cases (23.8%). The total number of hospital visits was 3,823. According to departments, Family Medicine had 968 visits(25.3%) of all, follewed by Pediatrics with 503 visits(13.2%), Internal Medicine 406visits(10.6%) and Dermatology 355visits(9.3%). The most common diagnoses were preventive medical cares such as general medical examination(6.0%), vaccination(4.5%), antenatal care(3.4%) and special investigations (3.1%), followed by acute infectious diseases such as acute upper respiratory infection including acute pharyngitis(7.4%), bronchitis(5.0%), infectious diarrhea(3.6%) and otitis media(2.9%) among top 20 ranks. preventive medical cares such as general medical examination and vaccination were more common in Family Medicine, and acute infectious diseases such as acute upper respiratory infection and bronchitis were more common in Internal Medicine and Pediatrics. preventive medical cares and acute infectious diseases were common without any differences between advanced countries(North America, Europe and Oceania, Japan) and developing countries(Asia, Africa, Latin America), except infectious diarrhea. Hospital visits due to infectious diarrhea were much more frequent among advanced countries (4.3% in Japan, 3.4% in the others) than developing countries(0.9%). CONCLUSIONS: According to the results, it showed the certain characteristics of the high medical need about preventive medical care and acute infectious diseases among foreign patients staying in Korea. It also shows the need of family physicians who could play important roles in practicing preventive medical care and acute common diseases for foreigners. Therefore it is believed that further studies for foreign patients in Korea will be necessary and should be conducted in the future.
Africa ; Americas ; Asian Continental Ancestry Group ; Bronchitis ; Communicable Diseases ; Dermatology ; Diagnosis ; Diarrhea ; Emigrants and Immigrants ; Europe ; Female ; Humans ; Internal Medicine ; Japan ; Korea ; Male ; Oceania ; Otitis ; Outpatients* ; Pediatrics ; Physicians, Family ; Vaccination

BACKGROUND: With the increasing numbers of foreign residents and tourists in Korea, the need of medical care systems for foreign patients seems to be growing, but there are few studies related with foreigners staying in Korea so far. This study was conducted to obtain the basic clinical data of foreign patients for the better medical care of them. METHODS: This study is an analysis of 1,405 outpatients in International(Foreign) Clinic of Kangbuk Samsung Hospital from Jan. 1 1994 to Dec. 31 1996. Patient charts were reviewed and analyzed. RESULTS: Of the total of 1,405 cases, 833 cases(59.3%) were males and 572 cases(40.7%) were females. The largest age group was the 4th decades, which were 408 cases(29.0%). By racial grouping, Japanese were the largest, accounting for 507 cases(36.1%) of all, followed by Europeans(including Oceanians) with 384 cases(27.3%) and North Americans with 335 cases (23.8%). The total number of hospital visits was 3,823. According to departments, Family Medicine had 968 visits(25.3%) of all, follewed by Pediatrics with 503 visits(13.2%), Internal Medicine 406visits(10.6%) and Dermatology 355visits(9.3%). The most common diagnoses were preventive medical cares such as general medical examination(6.0%), vaccination(4.5%), antenatal care(3.4%) and special investigations (3.1%), followed by acute infectious diseases such as acute upper respiratory infection including acute pharyngitis(7.4%), bronchitis(5.0%), infectious diarrhea(3.6%) and otitis media(2.9%) among top 20 ranks. preventive medical cares such as general medical examination and vaccination were more common in Family Medicine, and acute infectious diseases such as acute upper respiratory infection and bronchitis were more common in Internal Medicine and Pediatrics. preventive medical cares and acute infectious diseases were common without any differences between advanced countries(North America, Europe and Oceania, Japan) and developing countries(Asia, Africa, Latin America), except infectious diarrhea. Hospital visits due to infectious diarrhea were much more frequent among advanced countries (4.3% in Japan, 3.4% in the others) than developing countries(0.9%). CONCLUSIONS: According to the results, it showed the certain characteristics of the high medical need about preventive medical care and acute infectious diseases among foreign patients staying in Korea. It also shows the need of family physicians who could play important roles in practicing preventive medical care and acute common diseases for foreigners. Therefore it is believed that further studies for foreign patients in Korea will be necessary and should be conducted in the future.
Africa ; Americas ; Asian Continental Ancestry Group ; Bronchitis ; Communicable Diseases ; Dermatology ; Diagnosis ; Diarrhea ; Emigrants and Immigrants ; Europe ; Female ; Humans ; Internal Medicine ; Japan ; Korea ; Male ; Oceania ; Otitis ; Outpatients* ; Pediatrics ; Physicians, Family ; Vaccination

No abstract available.
Functional Food* ; Prescriptions*

Fifty four patients who received closed hemorrhoidectomy were randomized into two parallel groups and treated with Venitol(R)(a micronized flavonoidic fraction containing diosmin 450 mg and hesperidin 50 mg) (group 1) or placebo (group 2). Venitol(R) was administered at the dosage of three toblets b.i.d. the first four days and two tablets b.i.d following three days. Postoperative analgesia and laxative prescription as well as hospital stay were same in two groups. Though there is no difference of symptoms at D1, improvement of symptoms of complications was greater in group 1 than in group 2 at D18. The clinical severity of postoperative spot-bleeding, pain and anal discharge diminished in both groups but to a greater extent in group 1 (P<0.005). There was no side-effects in using Venitol(R). In summary, Venitol(R) is effective in reducing complications after hemorrhoidectomy.
Analgesia ; Diosmin ; Hemorrhage ; Hemorrhoidectomy* ; Hesperidin ; Humans ; Length of Stay ; Prescriptions ; Prospective Studies* ; Tablets

No abstract available.
Animals ; Carcinoma, Hepatocellular* ; Epidermal Growth Factor* ; Rats*

It is generally accepted that tbe lepromin test is of great value in the type classification and the evaluation of the prognosis of leprosy. But the nature of the antigenicity in lepromin reaction stiIl remains uncertain. The present study was carried out to investigate the antigenic characteriatics of the early(Fernandez) and the late (Mitsuda) reactions to Mitsuda lepromin antigen. Mycobacterium leprae was purified by trypsin digestion from human lepromas, and was broken down by passing 5 times through a French Pressor at 16, 000 p.s.i.. From the broken cell suspension, cell wall, cytoplasm, very low density lipoprotein (VLDL) and lipopolysaccharide (LPS) were prepared. IntradermaI skin tests were perforrned on 30 leprosy patients classified according to the Ridley-Jopling scale (4 TT, 6 BT, 2 BB, 7 BL and 11 LL), with 0. 1ml of the Mitsuda lepromin(intact cells) broken cells, cell wall, cytoplasm, VLDL and LPS antigens. Readings for the early and the late reactions were done 72 hours and 28 days, respectively, after itradermal injections of the above antigens. The results are summerized as follows: 1, Early reactions were elicited by broken cells, cell wall and cytoplasm in all of the patients who could react to Mitsuda lepromin antigen. VLDL and LPS antigens could also elicit early reactions in 9(56)% and in 14(88%), respectively, of the 10 patients who showed positive reaction to Mitsuda lepromin antigen. These results mean that the early reaction may be due to multiple antigena, originated either from M. leprae or from contaminated human tissues. 2. Late reactions were elicited by broken cells and cell wall antigens, but not by cytoplasm antigen, in all of the patients who showed late reactions to Mitsuda lepromin antigen. These results mean that broken cells also produce a late reaction and the specific antigen(s) of the late reaction may reside in the cell wall fraction of the M. leprae.
Cell Wall ; Classification ; Cytoplasm ; Digestion ; Humans ; Lepromin* ; Leprosy ; Lipoproteins ; Mycobacterium leprae ; Prognosis ; Reading ; Skin Tests ; Trypsin