Objective To observe the efficacy of oxcarbazepine monotherapy on adult patients with temporal lobe epilepsy (TLE). Methods Eighty-nine patients with TLE who were admitted to hospital from July 2011 to December 2014 were enrolled in this study. They had underwent surgery. Depending on the postoperative treatment they were divided into oxcarbazepine group (46 patients) and carbamazepine group (43 patients) group. They were treated by oxcarbazepine and carbamazepine after operation. The efficacy and complication were compared. Results The patients in two groups were followed up for 1.5 years. According to Engel grade, the number ofⅠ, Ⅱ, Ⅲand Ⅳ grade in oxcarbazepine group was 29, 10, 5 and 2 patients, in carbamazepine group was 26, 9, 5 and 3 patients, and there was no significant difference (P>0.05). The rate of adverse effect in oxcarbazepine group was 6.5%(3/46), in carbamazepine group was 20.9%(9/43), and there was significant difference (P<0.05). At the end of follow-up, the scores of generic quality of life inventory (GQOLI-74) in oxcarbazepine group was (74.6 ± 2.9) scores, in carbamazepine group was (65.1 ± 3.2) scores, and there was significant difference (t=9.838, P=0.000). Conclusions The efficacy of oxcarbazepine and carbamazepine shows no significant difference in adult TLE.But oxcarbazepine monotherapy has fewer adverse effects and more security.

Description of a multi-perspective view of harmonious doctor-patient relationship holds that medical social workers as a key tie for building such a relationship.It proposed the medical social work strategies for such workers in the face of patients and their families,hospital staff,and hospital management.

This paper described 8 patients in whom a spontaneeus renal subeapsular hematoma devel-oped.Two cases with systemic hypertension by the mechanism described by Page were observed.The diagnosis was confirmed by CT and ultrasound,and the patients were treated by means of the hematoma aspiration guided by uttrasound,8 cases were cured.The blood presure in 2 patients with Page's kidney was dropped to normal.No relapse was dernon,vtrated by follLw-up.Author reconlmend this treatment in such cases based on uhrasound and CT finding that rule OUt underlying pathological changes.

Objective:To compare the therapeutic effects between the Governor Vessel-regulating, liver-soothing and mind-calming needling and the routine acupuncture therapy for insomnia due to liver fire disturbing the heart.
Methods:A total of50 cases with insomnia were randomly divided by the random numberl table into the two groups, 25 cases in each group. The observation group was treated with the Governor Vessel-regulating, liver-soothing and mind-calming needling, while the control group was treated with the routine acupuncture therapy. The two groups were treated for five sessions per week, ten sessions as a course. After 3-course treatment, the therapeutic effects and the improvement of Pittsburgh sleep quality index (PSQI) were observed.
Results:After treatment for three courses, the total effective rate was 100% in the treatment group and 92% in the control group. The difference in the therapeutic effect between the two groups was statistically significant (P<0.05). After the treatment, thesleep latency, sleep duration, habitual sleep efficiency, subjective sleep quality, sleeping disturbances, daytime dysfunction, and total PSQI scores in the patients of the two groups were obviously improved in comparing those before treatment, with significant differences (allP<0.01). After treatment, the inter-group differences in the sleep latency, sleep duration, habitual sleep efficiency, subjective sleep quality, and total PSQI scores were statistically significant (all P<0.01); the differences in the scores of sleeping disturbances and daytime dysfunction is not statistical significant (all P>0.05).
Conclusion:Thetherapeutic effect of Governor Vessel-regulating, liver-soothing and mind-calming needling is better for insomnia due to liver fire disturbing the heart than the routine acupuncture therapy.

Objective: To evaluate shaping ability of nickel-titanium rotary instruments (Hero 642) in curved root canals. Methods:The computer assistant measure system of simulated root canal was used for quantitative analysis of root shape in eight simulated root canals during nickel-titanium rotary instruments (Hero 642) shaping process. Results:Nickel-titanium rotary instruments (Hero 642) could keep the curved angles in simulated canals very well. The cutting of Hero 642 in curved root canals was balanced and there was almost no transportation of canals central lines when the simulated canals were prepared to 0.02 taper 25~# and 30~# files. Conclusion:Nickel-titanium rotary instruments (Hero 642) has good shaping ability. In preparation of highly curved canals, the master apical file (MAF) may be Hero 642 0.02 taper 30# files.

The emergence of drug resistance mutations in human immunodeficiency virus (HIV) genome is the major reason for antiviral treatments failure.To investigate the drug-resistance viral quasispecies in HIV-infected individuals and to find out the new drug resistance mutations have significant effects on directing effective clinical treatment and developing novel antiviral drugs.HIV drug resistance tests mainly include genotypic drug susceptibility assay and phenotypic drug susceptibility assay.We reviewed in this article some novel development in the field.

Objective To explore the clinical value of serum tumor markers including CEA,AFP,CA199,CA125,CK19,CA242 and CA724 in diagnosis of pancreatic adenocarcinoma in the elderly.Methods Totally 158 elderly and 102 middle-aged patients with pancreatic adenocarcinoma were selected.Pancreatic adenocarcinoma in all patients were confirmed by pathological examination,cytological examination and CT.100 elderly and 100 middle-aged patients with benign diseases were selected as control groups.The levels of serum tumor markers were detected and their sensitivities and specificities were calculated and compared between groups.Results The levels of serum CEA,CA199,CA125,CK19,CA242 and CA724 were higher in elderly patients with pancreatic adenocarcinoma than in the elderly control group [(70.9±11.4) g/L vs.(1.6±0.4) g/L,(158.9±19.1)U/mlvs.(12.6±3.2)U/ml,(53.9±15.4)U/mlvs.(11.6±1.1)U/ml,(70.2±16.3)U/ml vs.(1.4±0.2)U/ml,(96.4±18.5)U/ml vs.(7.9±2.2)U/ml,(57.6±13.6)U/ml vs.(4.4± 0.6)U/ml,t=26.13,31.63,17.57,19.03,20.95,15.59,respectively,all P＜0.05].The sensitivities of serum CEA,AFP,CA199,CA125,and CA242 were higher in the elderly patients than in the middle aged patients (61.72％ vs.48.69％,19.56％ vs.4.13％,80.31％ vs.69.55％,70.21％ vs.46.77％,75.24％ vs.59.44％,x2=4.28,12.63,3.94,14.32,7.23,respectively,all P＜0.05).The specificities of serum CEA,AFP,CA199,CA125,and CA242 had no significant differences between the elderly and middle aged patients (all P＞0.05).Conclusions Serum tumor markers may provide effective reference for the clinical diagnosis of pancreatic adenocarcinoma in the elderly,which has important value for pancreatic adenocarcinoma control and reversal.

Objective To explore the application of ultrasonography (US) 5-grade system in the diagnosis of nasopharyngeal carcinoma(NPC).Methods A total of 150 patients suspected of having NPC underwent ukrasonography and MR imaging.All the lesions were scored according to the two different methods.Pathological results were made the golden criteria.The diagnosis accuracy of ultrasonography and MR imaging for NPC was evaluated using receiver-operating curve (ROC) analysis by Medcalc software.Results Both ultrasonography and MR imaging exhibited a good diagnostic performance for NPC with area under the curve (AUC) values of 0.958 and 0.987,respectively.The AUC difference of the two methods were statistically significant(Z =2.827,P =0.005).Conclusions Ultrasonography 5-grade system was an initial quantitative criterion for nasopharyngeal carcinoma diagnosis.The diagnosis accuracy was high although lower than MRI.But it could provide an overall economical and convenient complementary technique for clinical diagnosis.

OBJECTIVETo evaluate the effects of thermal and mechanical cycling on the metal-ceramic bond strength of machine-milled Ti2448 alloy and commercial pure titanium (cp Ti).

METHODSCeramic-cp Ti (n = 30) specimens and ceramic-Ti2448 combinations (n = 30) were prepared in accordance with ISO 9693. The specimens from each metal-ceramic combination were randomly divided into three subgroups. In group A or the control group, the specimens were only stored in distilled water for 24 h at 37 °C; in groups B and C, the specimens were subjected to 3,000 cycles of thermal cycling between 5 and 55 °C for a dwell time of 60 s and to mechanical cycling of 20,000 or 40,000 cycles with 50 N load and 4 Hz in distilled water at 37 °C. A crack initiation test was performed using a universal testing machine in accordance with ISO 9693. Failure types at the metal-ceramic interface and the morphological and elemental composition of this interface were analyzed using a scanning electron microscope and an energy dispersive spectrometer. Statistical analysis was performed via two-way ANOVA and Tukey's adjustment test (α = 0.05).

RESULTSThe bond strength of the ceramic-Ti2448 combination was significantly higher than that of the ceramic-cp Ti combination regardless of fatigue conditions (44.86 MPa ± 1.75 MPa and 29.21 MPa ± 2.20 MPa for Ti2448 and cp Ti, respectively; P < 0.01). The mean bond strengths of ceramic-cp Ti and ceramic-Ti2448 combinations in group C were significantly lower than that of group A (P < 0.01). Although ceramic-cp Ti combination failed adhesively at the metal-ceramic interface without the ceramic on the substrate surface, Ti2448 frameworks exhibited cohesive failure; as a result, large amounts of residual porcelain were retained on the specimens.

CONCLUSIONThe metal-ceramic bond strength of cp Ti and Ti2448 is decreased by thermal and mechanical cycling.

Endometrial Neoplasms ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; methods ; Lymph Nodes ; pathology ; Neoplasm Staging ; Ovarian Neoplasms ; pathology ; surgery ; Retroperitoneal Space