The authors observed a case of typical pemphigus foliaceus who was 26 year old male. The pemphigus foliaceus is a rare chronic vesicobullous skin disease which is a type of pemphigus, which has been reported rarely in Korea. This patient has been compained of formication of the face, trunk and upper arms since 7 monthes ago. The skin lesion revealed pea sized, flaccid bullar formation and dark bownish colored hyperpigmented macular eruptions with scattering distribution on the face, trunk, back and upper arms. This patient has experienced localized and generalized exfoliation during 7 rnonthes after onset, but he has not affected in general health condition. Biopsies were performed from the skin of the back, left wrist, and histopathologically the skin showed typical pemphigus foliaceus. So, diagnosis was confirmed by clinical appearance, histopathological finding and others. This patient was markedly imporved by prednisolone without immunesuppressant drugs, and antibiotics and antihistaminics etc.
Adult ; Anti-Bacterial Agents ; Arm ; Biopsy ; Diagnosis ; Humans ; Korea ; Male ; Paresthesia ; Peas ; Pemphigus* ; Prednisolone ; Skin ; Skin Diseases ; Wrist

Warts are benign turnors caused by oncogenic human papovavirus which has been clearly identified on electronmicroscopy, although repeated atternpts at culture have not been successful. Various therapeutic modalities have been tried for the treatment of warts, however thete is no saisfactory method and the clinical course as well as the prognosis is always variable. Recently several authors have reported successful therapeutic results in the treatment of warts by DNCB sensitization method based on the findings that warts are often regressing spontaneously and that the spontaneous regression seems to depend on host's ability to mount an immune response against the wert virus. The present study was undertaken to evaluate the DNCB sensitization method for possible routine use in the treatment of warts. Fifteen cases including five verruca vulgaris and ten verruca plana juvenilis patients were sensitized with 1000ug of DNCB in acetone solution on either side of their inner forearms. Seven or ten days after sensitization, several warts, which were unintentionally selected, were challenged with 0.05 to 0.1ml of weaker DNCB solution(50ug-25ug/0.1ml)at weekly interval. Four patients with verruca vulgaris and three patients with verruca plana juvenilis did not return after 1 to 4 times of challenge, however six out of these 7 patients showed a slight decrease in size and number of the warts. One patient with verruca plana juvenilis developed marked irritative and delayed cutaneous hypersensitivity reaction to the 3 times of challenge, so that this patient was excluded from further study. The remaining 7 patients consisted of I verruca vulgaris and 6 verruca plana juvenilis patients showed complete disappearance of all warts including those which were never challenged, after 1 to 13 times of DNCB challenge application. The authors reviewed the possible therapeutic mechanism of DNCB sensitization in the wart patients, the possible advantage and disadvantage of this method and concluded that this method can be cautiously used in seleted patients with warts whose response to the conventional treatment methods are poor.
Acetone ; Dinitrochlorobenzene* ; Forearm ; Humans ; Hypersensitivity ; Prognosis ; Warts*

Overexpression of the nuclear phosphoprotein p53 is the most common genetic anomaly found in primary human cancer and mutation of the tumor suppressor gene p53 has been identified in breast cancer cell lines. In this study, we evaluated the prognostic significance of p53 protein expression in patients with mammary infiltrating ductal carcinoma and its correlation with histopathologic grade, lymph node status, tumor size, p53 protein expression and survival. Among 53 cases, p53 protein expression was detected in 26(49.1%) cases by immunohistochemistry. There was no correlation between p53 protein overexpression and histopathologic grade(p=0.09) or lymph node status(p=0.38) and between survival and histopathologic grade (p=0.68) or lymph node status(p=0.52). However, p53 protein expression was significantly correlated with survival(p=0.01) and patients with p53 protein-positive tumors showed poorer survival times. But Cox multivariate analysis showed the lymph node status is significant(p=0.01). The authors conclude that the presence of mutant p53 protein and lymph node status may serve a prognostic role, in a subset of mammary infiltrating ductal carcinoma cases.
Humans ; Genes, Tumor Suppressor ; Breast Neoplasms

Legg-Perthes' disease, as avascularity of the femoral head that often arises in the child of a particular age group, is a serious disease of which the frequency is more than the osteochondroses of the other part, and the cause of Legg-Perthes disease is obscure up to now, but the pathogenesis and, pathology are more clearly understood. Twenty patients with Legg-Perthes disease were managed at the department of Orthopaedic Surgery of Hanyang University hospital from May, 1972 till September, 1977 and were studied according to the method of Catterals classification arid arthrogram. The following conclusion were made. 1. The age group with the highest frequency was that from 6 to 9 years (40%) and the ratio of male: female was 6: 1. 2. The stage of disease s progress when patient went to hospital was almost fragmentation stage as 17 persons of the whole. 3. By arthrogram Spherical form of femoral head was 15%; Round form 45%; Flatten form 40%. 4. The longer the period from onset to beginning of treament was the more femoral head flattened. 5. There was the most number of patient as 13 persons of the whole wearing abduction internal rotation brace. 6. From the view point of arthrogram the more spherical the femoral head was the better the prognosis was; otherwise the worse.
Arthrography ; Braces ; Child ; Classification ; Disease ; Female ; Head ; Humans ; Legg-Calve-Perthes Disease ; Male ; Methods ; Osteochondrosis ; Pathology ; Prognosis

Hodgkin's disease, as a poly-morphous group of lymphoma, is a disease of reticuloendothelial system, skin and usually affects the lymph node and so primarily, predominantly by proliferation of lymphocyte and histiocyte. This patient is a 42 years old Housewife who was suffered from severe itching sensation on the entire body since she had illed with exfoliative decmatitis, 7 years ago. Skin lesion showed brownish colored hyperpigmentation on entire body, scattered or grouped lichenified patch with scale on extremities and hypertrophy on the palms and soles. On physical examination, she had a egg-sized, right cervical lymph node swelling and chestnut sized, left cervical lymph node swelling without pain. On laboratory findings showed within normal limits. Sternal bone marrow aspiration revealed nonspecifie findings. A chest X-Ray revealed mass shadow on right upper mediastinum. Histologically finding of the skin revealed nonspecific dermatitis picture. On diagnostic excisional biopsy of left cervical lymph node showed numerous Hodgkin's cell Liver scanning didn't show space occeuying lesion. Above as a result, by clinical manifestation, X-ray findings and histological findings of cervical lymph-node, the diagnosis of Hodgkins disease with nonspecific dermatitis was confirmed. Literature was briefly reviewed for the discussion of clinical and histological findings of this dlsease.
Adult ; Biopsy ; Bone Marrow ; Dermatitis* ; Diagnosis ; Extremities ; Histiocytes ; Hodgkin Disease* ; Humans ; Hyperpigmentation ; Hypertrophy ; Liver ; Lymph Nodes ; Lymphocytes ; Lymphoma ; Mediastinum ; Mononuclear Phagocyte System ; Physical Examination ; Pruritus ; Sensation ; Skin ; Thorax

In the developed countries in Europe and the United States, The spinal tuberculosis is of no serious problem due to the developed anti-tuberculotic agents and the advanced operative techniques. However, in Korea poor economic and other conditions prevent many patienta from getting proper treatments for spinal tuberculosis. We analysed 45 cases of spinal tuberculosis who were treated at our department during three years from June, 1972 to June, 1975 by operative treatment and being compared with these results that obtained conservative treatment. The results were obtained as follows; 1. There was most common in below 9 years old (28.9%) and common age incidence was below 35 years old (68.8), The sexual incidence was 22 in male and 23 in female. 2. Lower thoracic and upper lumbar were mostly involved, i.e thoracic (52.2%), lumbar (32.7%), thoraco-lumbar in orders. 3. Two affected vertebra was most common in 33 cases, number of affected vertebra averaged 2.5. 4. In laboratory finding, E.S.R. that was 50–60 mm/hr. in average of then admission wss shifted as normal range of 10–20 mm/hr. after cure of 5–6 months. 5. In 28 cases of operative treatment, anterior spinal fusion was done in 19 cases (67.9%), posterior spinal fusion in 8 cases(28.6%), one case(3.5%) was treated by thoracotransversectomy. 6. In consequence of pathologic exaraination and A.F.B. stain, the case of tuberculotic constitution was 18 in tissue pathology, and that of positive reaetion was 9 in direct smear for A.F.B. 7. The case that tuberculosis was limited at spine and was not found in other organs was 27, it got from 60% of the whole. 8. Average kyphotic angle of the thoracic region after operation was 4.3°, in 6 months was reduction of 1.8°, that of lumbar region after operation was 1.2°, in 6 months was reduction after operation was reduction of 0.7°, as change of radiologic kyphosis. 9. As a result of being cured during 18 months by operative or conservative methods, not a case is found in activity.
Constitution and Bylaws ; Developed Countries ; Europe ; Female ; Humans ; Incidence ; Korea ; Kyphosis ; Lumbosacral Region ; Male ; Pathology ; Reference Values ; Spinal Fusion ; Spine ; Tuberculosis ; Tuberculosis, Spinal ; United States

This study represents the radiologic, histologic features & clinical analysis of hyaline mambrane disease in 47 newborn infants who were delivered in Ewha Womans Univ. Hospital & expired caused by repiratory distress & confirmed by autopsy , during Jan. 1981 to June, 1984. The results were as follows; 1. Classification ofradiolgraphic stage (by Wolfson's criteria); Stage III(34.1%) was the most frequent. 2. Male to female ratio was 2.4:1. 3. Method of delivery; Cesarean section (44.7%) was the highest frequency, compared with percent ofcesarean section to total delivery(29.0%). 4. Distribution of birth weight; 1.0-2.0 Kg(48.9%) was the mostfrequent. 5. Distribution of gestational period; 32-36 weeks (29.8%) was the most frequent. 6. Complication; Pulmonary hemorrhage(31.9%) was the most frequent, in order, subarachnoid hemorrhage & pneumothorax were followed.7. Final diagnosis of hyaline membrane disease was based on histo-pathologic diagnosis.
Autopsy ; Birth Weight ; Cesarean Section ; Classification ; Diagnosis ; Female ; Humans ; Hyalin ; Hyaline Membrane Disease ; Infant, Newborn ; Infant, Newborn ; Male ; Methods ; Pneumothorax ; Pregnancy ; Subarachnoid Hemorrhage

First rnany years there has been a great dea,l of disagreement about the classification and histology of recalcitrant pustular eruptions of the palms and soles and the rela.tion of this condition to psoriasis. It ia the purpose of this investigation to describe histological changes in fresh pustules from patients witb pustular eruptions of the palms and soles and compare these changes between patients with clinically preceding or co-existing psoriasis (4cases) and without clinically preceding or co-existing psoriasis (7cases). Nine biopsies of pustules were exarnined and the results were compared between two groups. Histopathological findings were otherwise uniform and typical intradermal well-delineated pustules. No significant differences were found bet.ween th two groups. In view of the uniforrn histology, the unknown etiology, and uncertain clinicaI classification, the authors prefer the clearly descreptive term pustulosis palrnaris et plantaris(PPP). Recent;ly the phagocytic ability of neutrophilic leukocytes was reported to be impaired in patients suffering from pustular eruptions of the palms and soles. In our study this ability was performed with the aid of the NBT. dye reduction test before and after administration of Descresept (aristolochic acid). The aim of the present study was to observe the effect of Descresept on NBT test in relation to the clinical acitivity of PPP. The results were as follows: l. In 6 of 11 patients, clinical improvement was accompanied with increasing NBT' scores. 2. In 2 of 11 patients, clinical aggravation was noted in spite of Descresept adrninistration. In these 2 cases, increase in dosage of Descresept made clinical improvement again with increasing NBT scores. 3. In 3 of the 11 patients, there was noted clinical improvement, but NBT scores were slightly decreased.
Biopsy ; Classification ; Humans ; Leukocytes ; Neutrophils ; Psoriasis

Subtrochanteric fracture of the femur is more difficult to treat than other bone fracture. Subtrochanteric fracture occurs in bone that is predominently cortical and biomechanical analyeis of stress in the femur ahowed that there is a high concentration of stress in the subtrochanteric region. These two factors, involvement of cortical bone tissue and concentration of stress, frequently have been mentioned as reasons for the high incidence of complications in the treatment of these fractures. The authors treated 23 cases of subtrochanteric fracture of the femur in 1974 through 1981, at the Department of Orthopaedic Surgery, School of Medicine, Soon Chun Hyang College. The results were as follows: 1. Of 23 cases of subtrochanteric fracture, 15 cases occurred in man, 8 cases in woman. 2. The most common cause of fracture was due to traffic accident. 3. Of 23 cases of subtrochanteric fracture, 9 cases were type lI, and 7 cases were type I & II by Fielding's classification. 4. 19 cases out of 23 were treated by means of the open reduction and internal fixation. As the internal fixation material, we used Kuntscher nail, Smith-Peterson and Thornton plate, Compression hip screw and plate until December 1978, and Zickel nail from January 1979. 5. The mean duration of bony union in subtrochanteric fracture treated by Zickel nail was shorter than the other implants. The incidence of complications such as coxa vara, delayed union, metal breakage occurred higher in the cases treated by Kuntscher nail, Smith-Peterson nail and Thornton plate, Campression hip screw and plate. 6. Zickel nail is one of the good implant for the treatment of subtrochanteric fracture of the femur.
Accidents, Traffic ; Bone and Bones ; Classification ; Coxa Vara ; Female ; Femur ; Fractures, Bone ; Hip ; Humans ; Incidence

This study examined effect of preceptorship on clinical education of senior nursing students of Y. University in Seoul. Quasi-experimental study design was used. Sixty students of pre-test and 80 of post-test participated in this study. Competency scores of the students before the clinical education(pre-competency scores) were compared with the competency scores after the clinical education(post-competency scores), and teacher evaluation scores between preceptors and clinical the data from students with preceptors(experimental group, N=22) and with clinical instructors(comparative group, N=58) were also examined. Study results indicated that the total post-competency scores were higher compared to the total pre-competency scores, and the difference was statistically significant. Among 7 sub-domains, differences were all statistically significant in 6 sub-domains except "self-esteem" domain. Competency scores of the students who had clinical education with had clinical education from clinical instructors. But the difference between those scores was not statistically significant. However, students gave higher evaluation scores to preceptors than clinical instructors. This study concluded that preceptorship did not influence much on clinical education at this time yet. However it is expected that when preceptors adjust their new roles and function them in expert education. This study recommended that for the preceptors to increase their motivation to teach students and to accept their roles, systemic rewards are needed.
Education* ; Humans ; Motivation ; Nursing* ; Preceptorship* ; Reward ; Seoul ; Students, Nursing*