No abstract available.
Endodermal Sinus Tumor* ; Lung* ; Neoplasm Metastasis* ; Yolk Sac*

Primary intracranial yolk sac tumor usually arises in the pineal or suprasellar area and shows poor prognosis. Several children with primary yolk sac tumor in the cerebellum have been reported in the literature, and none of these survived beyond 30 months. We report a case of primary yolk sac tumor in the cerebellum showing longer survival with intensive multimodal combined therapy using surgery, preirradiation chemotherapy, and irradiation.
Cerebellum ; Child ; Drug Therapy ; Endodermal Sinus Tumor* ; Humans ; Prognosis ; Radiotherapy ; Yolk Sac*

Endodermal sinus tumors(EST) have also been referred to as "yolk sac tumors" because they are derived from the primitive yolk sac. These lesions are the third most frequent malignant germ-cell tumors of the ovary. Recent advances in treating the endodermal sinus tumor of the ovary with the combination chemotherapy result in improvement of the prognosis. We had experienced a case of the endodermal sinus tumor of 15 year old woman. We report this case with a brief review of literatures.
Adolescent ; Drug Therapy, Combination* ; Endoderm* ; Endodermal Sinus Tumor* ; Female ; Humans ; Ovary* ; Prognosis ; Yolk Sac

We report herein a case of gastric undifferentiated carcinoma with focal yolk sac tumor and hepatoid carcinoma differentiation. A 57-year-old man was referred after a gastroscopy for anemia evaluation. Gastroscopy revealed an approximately 3 cm ulcerofungating mass occupying the greater curvature of stomach body. Biopsy results revealed a poorly differentiated adenocarcinoma. Left gastric lymph node was enlarged, but there were no evidence of distant metastasis on the abdominal CT. He underwent a radical subtotal gastrectomy and gastroduodenostomy with dissection of the enlarged lymph nodes. Postsurgical histological examination revealed an undifferentiated carcinoma with focal yolk sac tumor and hepatoid carcinoma differentiation. Immunohistochemical staining revealed that the tumor cells were focal positive for AFP, anti-hepatocyte antibody.
Adenocarcinoma ; Anemia ; Biopsy ; Carcinoma ; Endodermal Sinus Tumor ; Gastrectomy ; Gastroscopy ; Lymph Nodes ; Neoplasm Metastasis ; Stomach ; Yolk Sac

Extragondal germ cell tumors are rare, which develop outside of the testes, but histologically identical to primary testicular germ cell tumors. There have been much interest and controversies about their etiology, definition, treatment and care of testes. We recently experienced a case of primary mediastinal yolk sac tumor in a 16-years-old male, who was cured by intensive chemotherapy and cytoreductive surgery. Herein we report the case with review of the literature.
Drug Therapy ; Endodermal Sinus Tumor* ; Humans ; Male ; Neoplasms, Germ Cell and Embryonal ; Testis ; Yolk Sac*

The Beckwith-Wiedemann syndrome, which included congenital anomalies such as macroglossia, exomphalos, postnatal somatic gigantism, have a substantially increased risk for the development of tumor. We report a case of testicular yolk sac tumor associated with Beckwith-Wiedemann syndrome, a previously unreported association. Pathologic examination showed Schiller-Duval body with evidence of testicular yolk sac tumor. This finding appears to represent a previously unreported association between Beckwith-Wiedemann syndrome and testicular yolk sac tumor.
Beckwith-Wiedemann Syndrome* ; Endodermal Sinus Tumor* ; Gigantism ; Hernia, Umbilical ; Macroglossia ; Testis ; Yolk Sac*

A case of endodermal sinus tumor in the pineal region of a 12-year-old boy is presented. Preponderance of this tumor occurs in the boys, usually in their second decade. The tumor is characterized by perivascular structure(Schiller-Duval body) which simulate endodermal diverticula of yolk sac origin. His serum alpha-fetoprotein levels was abnormally high(over 400ng/ml) He was treated with operation and irradiation of 4500rad to the whole brain and spinal axis. But he died 6 month later after operation. The authors report a case of endodermal sinus tumor arising from pineal gland and briefly review literature.
alpha-Fetoproteins ; Axis, Cervical Vertebra ; Brain ; Child ; Diverticulum ; Endoderm* ; Endodermal Sinus Tumor* ; Humans ; Male ; Pineal Gland ; Yolk Sac

Endodermal sinus tumor (EST) has also been referred to as yolk sac carcinoma because they are derived from the primitive yolk sac. These lesions are the third most frequent malignant germ cell tumor of the ovary. Patient with EST have a median age of 18 years, but approximately one third of the patients are premenarchal at the time of initial presentation. Abdominal and/or pelvic pain is the most frequent presenting symptom, most EST secrete AFP. Radical surgery has not been helpful, but recent advances in treating the EST of the ovary with the combination chemotherapy after unilateral salpingo-oophorectomy result in improvement of the prognosis. We had experienced a case of endodermal sinus tumor of 36 years old woman. So, we report this case with brief review of the literature.
Adult ; Drug Therapy, Combination* ; Endoderm* ; Endodermal Sinus Tumor* ; Female ; Humans ; Neoplasms, Germ Cell and Embryonal ; Ovary* ; Pelvic Pain ; Prognosis ; Yolk Sac

Polyvesicular vitelline tumor of the ovary is an extremely rare variant of yolk sac tumor. We present a case of pure polyvesicular vitelline tumor in a 43-year-old woman. Light microscopy revealed a predominantly polyvesicular pattern embedded in mesoblastic stroma with the cysts showing two type of lining; tall columnar and cuboidal, or mesothelioid cells. The lining atypical cells showed occasional mitoses and intracytoplasmic PAS positive hyaline globules. In some areas, the cystic space contained a large amount of intraluminal hyaline material. Immunohistochemically, alpha- fetoprotein and alpha-1-antitrypsin were detected as a fine granular deposit in the cytoplasm of epithelial cells and hyaline globules. Electron microscopically, marked specialization of the vesicular lining cells suggested a differentiation toward gut structures and mature yolk sac.
Adult ; Cytoplasm ; Endodermal Sinus Tumor ; Epithelial Cells ; Female ; Fetal Proteins ; Humans ; Hyalin ; Microscopy ; Mitosis ; Ovary* ; Vitellins* ; Yolk Sac

Polyvesicular vitelline tumor of the ovary is an extremely rare variant of yolk sac tumor. We present a case of pure polyvesicular vitelline tumor in a 43-year-old woman. Light microscopy revealed a predominantly polyvesicular pattern embedded in mesoblastic stroma with the cysts showing two type of lining; tall columnar and cuboidal, or mesothelioid cells. The lining atypical cells showed occasional mitoses and intracytoplasmic PAS positive hyaline globules. In some areas, the cystic space contained a large amount of intraluminal hyaline material. Immunohistochemically, alpha- fetoprotein and alpha-1-antitrypsin were detected as a fine granular deposit in the cytoplasm of epithelial cells and hyaline globules. Electron microscopically, marked specialization of the vesicular lining cells suggested a differentiation toward gut structures and mature yolk sac.
Adult ; Cytoplasm ; Endodermal Sinus Tumor ; Epithelial Cells ; Female ; Fetal Proteins ; Humans ; Hyalin ; Microscopy ; Mitosis ; Ovary* ; Vitellins* ; Yolk Sac