1.Relationship between Coffee Consumption and Metabolic Syndrome in Korean Adults: Data from the 2013–2014 Korea National Health and Nutrition Examination Survey.
Hyekyung SHIN ; John A LINTON ; Yujin KWON ; Yohan JUNG ; Bitna OH ; Sinae OH
Korean Journal of Family Medicine 2017;38(6):346-351
BACKGROUND: The gradually increasing demand for coffee worldwide has prompted increased interest in the relationship between coffee and health issues as well as a need for research on metabolic syndrome in adults. METHODS: Data from 3,321 subjects (1,268 men and 2,053 women) enrolled in the 2013–2014 Korean National Health and Nutrition Examination Survey were analyzed. The subjects were divided into three groups according to their daily coffee consumption. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for metabolic syndrome in the coffee-drinking groups were calculated using multiple logistic regression analysis by adjusting for confounding variables. RESULTS: The prevalence of metabolic syndrome was 15.5%, 10.7%, and 9.7% in men and 3.0%, 7.1%, and 6.5% in women according to their coffee consumption (less than one, one or two, or more than three cups of coffee per day), respectively. Compared with the non-coffee consumption group, the ORs (95% CIs) for metabolic syndrome in the group that consumed more than three cups of coffee was 0.638 (0.328–1.244) for men and 1.344 (0.627–2.881) for women after adjusting for age, body mass index, household income, education, smoking, alcohol, regular exercise, and daily caloric intake. CONCLUSION: The OR of metabolic syndrome was not statistically significant in both men and women.
Adult*
;
Body Mass Index
;
Coffee*
;
Confounding Factors (Epidemiology)
;
Education
;
Energy Intake
;
Family Characteristics
;
Female
;
Humans
;
Korea*
;
Logistic Models
;
Male
;
Nutrition Surveys*
;
Odds Ratio
;
Prevalence
;
Smoke
;
Smoking
;
Waist Circumference
2.Laparoscopic Nissen Fundoplication in Children with Neurological Impairment versus Neurologically Normal Children.
Yohan JOO ; Ju Yeon LEE ; Jung Hyun CHOI ; Jung Man NAMGUNG ; Seong Chul KIM ; Dae Yeon KIM
Journal of the Korean Association of Pediatric Surgeons 2016;22(2):49-53
PURPOSE: This study aimed to assess the long-term clinical outcome of laparoscopic Nissen fundoplication (LNF) in children according to their neurologic status. METHODS: The study retrospectively analyzed the data of 82 children (62 neurologically impaired and 20 neurologically normal children with primary gastroesophageal reflux disease) who had undergone LNF between 2003 and 2012. The main outcome measures were the occurrence of recurrence that required reoperation and post-procedure complications such as infections, pneumonia, and gastrointestinal complications including ileus, dysphagia, and delayed gastric emptying. RESULTS: The median age at the time of the LNF was 25 months (range, 1-192 months), and the median of body weight was 10.0 kg (range, 2.8-37.0 kg). The average weight gain was 1.55±1.68 kg at 6 months, 3.32±2.30 kg at 1 year, and 5.63±4.22 kg at 2 years after surgery. Six (9.7%) of the 62 neurologically impaired patients and two (10.0%) of neurologically normal lost their body weight or had no weight changes. Eight (12.9%) of the 62 neurologically impaired children had required redo surgery because of gastroesophageal reflux disease recurrences, while 2 (10.0%) of the 20 neurologically normal children had experienced recurrences. In the neurologically impaired children, the postoperative complications included pneumonia (n=1), wound infection (n=1), urinary tract infection (n=1), dysphagia (n=1), delayed gastric emptying (n=1), and ileus (n=2). All of these complications were not found in the neurologically normal group, except for only one case of infectious colitis. However, there was no statistically significant difference between the two groups in postoperative complications. CONCLUSION: The outcomes of laparoscopic fundoplication were similar in the neurologically impaired children and in the neurologically normal children.
Body Weight
;
Child*
;
Colitis
;
Deglutition Disorders
;
Fundoplication*
;
Gastric Emptying
;
Gastroesophageal Reflux
;
Humans
;
Ileus
;
Laparoscopy
;
Neurologic Manifestations
;
Outcome Assessment (Health Care)
;
Pneumonia
;
Postoperative Complications
;
Recurrence
;
Reoperation
;
Retrospective Studies
;
Urinary Tract Infections
;
Weight Gain
;
Wound Infection
3.A Case of Deep Vein Thrombosis Following Cellulitis of the Lower Leg.
Woojin JUNG ; Youngji KIM ; Yohan PARK ; Junhyeon CHO ; Gi Chang KIM
Korean Journal of Medicine 2014;86(3):334-338
Cellulitis and deep vein thrombosis (DVT) have similar symptoms (lower extremity pain, erythema, and swelling) and there is the potential for misdiagnosis. In cases of cellulitis, DVT should be ruled out, as the symptoms of cellulitis might mask those of DVT, leading to serious complications such as pulmonary thromboembolism. The reported incidence of DVT in patients with cellulitis is low, especially patients with progression to pulmonary thromboembolism. We present a case of pulmonary thromboembolism following cellulitis of the lower leg in a 54-year-old male.
Cellulitis*
;
Diagnostic Errors
;
Erythema
;
Extremities
;
Humans
;
Incidence
;
Leg*
;
Male
;
Masks
;
Middle Aged
;
Pulmonary Embolism
;
Venous Thrombosis*
4.Recurrent Transient Ischemic Attacks Caused by Postprandial Hypotension in a Patient with Occlusion of Right Internal Carotid Artery.
Jinkwon KIM ; Yohan JUNG ; Sang Won HAN ; Byung In LEE ; Kyung HEO
Journal of the Korean Neurological Association 2006;24(4):356-358
We report a 72-year-old man suffering from recurrent attacks of transient drowsy mentality during meal or on orthostatic body position. Markedly disturbed collateral blood flow to right hemisphere was observed on conventional cerebral angiography. Acute and old ischemic lesions in the right internal borderzone area were also noticed on magnetic resonance image. Postprandial and orthostatic hypotension in the present case could be the cause of the recurrent neurological deficit developed in the primarily disturbed collaterals in the right middle cerebral territory.
Aged
;
Carotid Artery, Internal*
;
Cerebral Angiography
;
Humans
;
Hypotension*
;
Hypotension, Orthostatic
;
Ischemic Attack, Transient*
;
Meals
5.Case Series of Different Onset of Skin Metastasis According to the Breast Cancer Subtypes.
Junhyeon CHO ; Yohan PARK ; Jong Chan LEE ; Woo Jin JUNG ; Soohyeon LEE
Cancer Research and Treatment 2014;46(2):194-199
We report on five cases of skin metastasis according to the breast cancer (BC) subtype. Two cases of HER2 positive BC showed only skin metastasis after immediate postoperative period and rapid clinical response to targeted therapy. Another two cases of triple negative BC showed thyroid and lung metastasis in addition to skin metastasis, and their response of cytotoxic chemotherapy was not definite. The other hormone positive BC showed skin metastasis only, with a longer, slower, less progressive pattern than other subtypes. Most cases of skin metastasis were detected at terminal stage of malignancy and were considered to have a limited survival period. However, some BC patients can survive longer if the targeted agents are effective. Therefore, physicians should provide detailed follow up of BC after curative treatment and understand the metastatic pattern of BC according to the subtype.
Breast Neoplasms*
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Drug Therapy
;
Humans
;
Lung
;
Neoplasm Metastasis*
;
Postoperative Period
;
Skin Neoplasms
;
Skin*
;
Thyroid Gland
6.Seeing Is Believing: The Effect of Graphical Abstracts on Citations and Social Media Exposure in Gastroenterology & Hepatology Journals
Yohan KIM ; Jieun LEE ; Jeong-Ju YOO ; Eun-Ae JUNG ; Sang Gyune KIM ; Young Seok KIM
Journal of Korean Medical Science 2022;37(45):e321-
Background:
Graphical abstracts (GAs) have recently been included as an essential element in various journals, including those in the field of Gastroenterology & Hepatology. However, there has been no study on the effect of GAs on the impact factor (IF) of journals, and the citation index or social media exposure of individual articles.
Methods:
We investigated the presence of GAs, total citations and social media exposure of full-length original articles in the top ten journals of gastroenterology and hepatology for three years (2019–2021). Citations and social media exposure were evaluated with the Web of Science citation index, Altmetric Attention score, Dimension recorded citation count, and PlumX index.
Results:
A total of 4,205 articles from ten journals were evaluated for three years. First, journals that have adopted GAs demonstrated significantly higher IF increases for the past three years than those of journals without GAs. The longer GAs have been utilized in a journal, the higher IFs the journal had. Secondly, individual articles with GAs had significantly higher Web of Science citation counts (median 14 vs. 12), more social media exposure (median 23 vs. 5) and more Altmetric.com tweet counts (median 15 vs. 7) than those of articles without GAs. In multiple regression analysis, the inclusion of GAs was particularly effective in increasing the number of Web of Science citations (β = 14.1, SE = 1.9, P < 0.001) and social media exposure (β = 13.3, SE = 6.1, P = 0.030) after adjusting for journal IFs and topics.
Conclusion
GAs are effective in increasing IFs of journals in the field of gastroenterology and hepatology, as well as increasing citations and social media exposure of individual articles.
7.Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells.
Joo Hui HAN ; Yohan KIM ; Sang Hyuk JUNG ; Jung Jin LEE ; Hyun Soo PARK ; Gyu Yong SONG ; Nguyen Manh CUONG ; Young Ho KIM ; Chang Seon MYUNG
The Korean Journal of Physiology and Pharmacology 2015;19(5):421-426
The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet-derived growth factor (PDGF) is believed to play a central role in the etiology of these pathophysiological situations. Here, we investigated the anti-proliferative effects and possible mechanism(s) of murrayafoline A, a carbazole alkaloid isolated from Glycosmis stenocarpa Guillamin (Rutaceae), on PDGF-BB-stimulated VSMCs. Murrayafoline A inhibited the PDGF-BB-stimulated proliferation of VSMCs in a concentration-dependent manner, as measured using a non-radioactive colorimetric WST-1 assay and direct cell counting. Furthermore, murrayafoline A suppressed the PDGF-BB-stimulated progression through G0/G1 to S phase of the cell cycle, as measured by [3H]-thymidine incorporation assay and cell cycle progression analysis. This anti-proliferative action of murrayafoline A, arresting cell cycle progression at G0/G1 phase in PDGF-BB-stimulated VSMCs, was mediated via down-regulation of the expression of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)2, CDK4, and proliferating cell nuclear antigen (PCNA), and the phosphorylation of retinoblastoma protein (pRb). These results indicate that murrayafoline A may be useful in preventing the progression of vascular complications such as restenosis after percutaneous transluminal coronary angioplasty and atherosclerosis.
Angioplasty, Balloon, Coronary
;
Atherosclerosis
;
Cell Count
;
Cell Cycle
;
Cyclin D1
;
Cyclin E
;
Cyclins
;
Down-Regulation
;
Muscle, Smooth, Vascular*
;
Phosphorylation
;
Phosphotransferases
;
Platelet-Derived Growth Factor
;
Proliferating Cell Nuclear Antigen
;
Retinoblastoma Protein
;
Rutaceae
;
S Phase
8.5,8-Dimethoxy-2-Nonylamino-Naphthalene-1,4-Dione Inhibits Vascular Smooth Muscle Cell Proliferation by Blocking Autophosphorylation of PDGF-Receptor beta.
Yohan KIM ; Jung Jin LEE ; Sang Gil LEE ; Sang Hyuk JUNG ; Joo Hui HAN ; So Young YANG ; Eunju YUN ; Gyu Yong SONG ; Chang Seon MYUNG
The Korean Journal of Physiology and Pharmacology 2013;17(3):203-208
As the abnormal proliferation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of atherosclerosis and vascular restenosis, a candidate drug with antiproliferative properties is needed. We investigated the antiproliferative action and underlying mechanism of a newly synthesized naphthoquinone derivative, 5,8-dimethoxy-2-nonylamino-naphthalene-1,4-dione (2-nonylamino-DMNQ), using VSMCs treated with platelet-derived growth factor (PDGF). 2-Nonylamino-DMNQ inhibited proliferation and cell number of VSMCs induced by PDGF, but not epidermal growth factor (EGF), in a concentration-dependent manner without any cytotoxicity. This derivative suppressed PDGF-induced [3H]-thymidine incorporation, cell cycle progression from G0/G1 to S phase, and the phosphorylation of phosphor-retinoblastoma protein (pRb) as well as the expression of cyclin E/D, cyclin-dependent kinase (CDK) 2/4, and proliferating cell nuclear antigen (PCNA). Importantly, 2-nonylamino-DMNQ inhibited the phosphorylation of PDGF receptorbeta(PDGF-Rbeta) enhanced by PDGF at Tyr579, Tyr716, Tyr751, and Tyr1021 residues. Subsequently, 2-nonylamino-DMNQ inhibited PDGF-induced phosphorylation of STAT3, ERK1/2, Akt, and PLCgamma1. Therefore, our results indicate that 2-nonylamino-DMNQ inhibits PDGF-induced VSMC proliferation by blocking PDGF-Rbeta autophosphorylation, and subsequently PDGF-Rbeta-mediated downstream signaling pathways.
Atherosclerosis
;
Cardiovascular Diseases
;
Cell Count
;
Cell Cycle
;
Cell Proliferation
;
Cyclins
;
Epidermal Growth Factor
;
Muscle, Smooth, Vascular
;
Phosphorylation
;
Phosphotransferases
;
Platelet-Derived Growth Factor
;
Proliferating Cell Nuclear Antigen
;
S Phase
9.First Case of Atypical, Generalized Skin Rash after Transarterial Chemoembolization in a Patient with Hepatocellular Carcinoma
Yohan LEE ; Eunae CHO ; Chang Hwan PARK ; Jae Hyun YOON ; Sung Kyu CHOI ; Hyoung Ook KIM ; Chan PARK ; Sook Jung YUN
The Korean Journal of Gastroenterology 2023;81(4):173-177
Transarterial chemoembolization (TACE) is a widely used hepatocellular carcinoma (HCC) treatment. Some cases of supraumbilical skin rash after TACE in patients with HCC have been reported. To the best of the authors’ knowledge, there are no reports on atypical, generalized rashes caused by doxorubicin systemic absorption after TACE. This paper presents the case of a 64-year-old male with HCC who developed generalized macules and patches one day after a successful TACE procedure. A histology examination of a skin biopsy of a dark reddish patch on the knee revealed severe interface dermatitis. He was treated with a topical steroid, and all skin rashes improved within a week with no side effects. This report presents this rare case with a literature review on skin rash after TACE.
10.Urinary Tract Infection Following Voiding Cystourethrography.
Jung Min RYU ; Yohan AHN ; Sohee LEE ; Hyun Jin CHOI ; Beom Hee LEE ; Hee Gyung KANG ; Il Soo HA ; Hae Il CHEONG ; Yong CHOI
Journal of the Korean Society of Pediatric Nephrology 2008;12(2):194-201
PURPOSE: Voiding cystourethrography(VCUG) is required to detect vesicoureteral reflux(VUR), which may manifest as urinary tract infection(UTI) in children. It is well known that VCUG can cause UTI(post-VCUG UTI). In this study, risk factors for post-VCUG UTI and the preventive effect of antibiotics against this complication of VCUG were explored. METHODS: Medical records of 284 patients who underwent VCUG at our hospital in 2007 were reviewed retrospectively. The incidence of post-VCUG UTI and risk factors for post-VCUG UTI, and the impact of antibiotic use on prevention of post-VCUG UTI were evaluated. According to antibiotics usage, we divided the enrolled patients into 4 groups of noantibiotics group, prophylactic antibiotics group(prophylactic antibiotics having been used before), antibiotics-for-VCUG group(antibiotics added for VCUG) and antibiotics-for-treatment group(treatment dose of antibiotics). RESULTS: Seven of 284 children(2.5%) developed UTI after they underwent VCUG. High-grade(grade> or =III) VUR was the only statistically significant risk factor(odds ratio[OR] 6.266, P=0.026) for post-VCUG UTI, while sex, age, and other anomalies of urinary system were not significant. Five post-VCUG UTI cases belonged to prophylactic antibiotics group. Antibiotics use (three groups using antibiotics vs. no-antibiotics group) or addition of antibiotics for VCUG (antibiotics-for-VCUG vs. other groups) did not have any effect on prevention of post-VCUG UTI. CONCLUSION: The risk factor for post-VCUG UTI was high-grade VUR. Antibiotics use did not prevent post-VCUG UTI in this study.
Anti-Bacterial Agents
;
Child
;
Humans
;
Incidence
;
Medical Records
;
Retrospective Studies
;
Risk Factors
;
Urinary Tract
;
Urinary Tract Infections