The propolis, honey bee hive product, is a folk medicine for treating various ailrnents and caffeic acid phenethyl ester (CAPE) is an extract of propolis. The purpose of this study was to examine the effects of ethanol extracted propolis (EEP) or CAPE on the tumorigenesis, pulmonary metastases, and proliferation and activity of splenocytes and macrophages in ICR mice. EEP at 0.2, 2 or 20mg/ml applied topically on the back of each mice 30 minutes before application of 7,12-dimethylbenz (a)anthracene and 12-0-tetradecanoylphorbol-13-acetate inhibited the number of tumors per mouse by 61, 75 or 100%, respectively. ...continue...
Animals ; Bees ; Carcinogenesis* ; Ethanol ; Honey ; Macrophages* ; Medicine, Traditional ; Mice* ; Mice, Inbred ICR ; Neoplasm Metastasis* ; Propolis*

Background: Ultrasonic devices have potential advantages over electrocautery surgical scalpels for muscle dissection, as they eliminate the risk of muscle contraction caused by electric currents. In this study, we investigated the outcomes of using both device types in subpectoral dissection for breast reconstruction. Methods: In this retrospective single-center study, we examined the electronic medical records of female patients with non-recurrent breast cancer who underwent breast reconstruction. The patients were treated with either Harmonic Focus+ Shears (HFS) or a Bovie electrocautery scalpel (BES) between January 2015 and April 2020. The primary clinical outcomes evaluated were total drainage volume, time to drainage tube removal, and operation time. To control for confounding, outcomes were stratified based on the type of tissue expander used—either Mentor or Natrelle. Results: The study included 303 patients; 155 (51.2%) were treated with HFS (mean age, 45.28±7.38 years) and 148 (48.8%) with BES (mean age, 44.41±9.37 years). Within each expander type, the frequency of drainage exceeding 30 cc per day after 21 postoperative days showed no statistical difference between the HFS and BES devices. The operation time was shorter for HFS in both the Mentor (85.13±19.81 minutes vs. 109.56±21.66 minutes, P<0.001) and Natrelle (88.09±20.64 minutes vs. 99.88±22.66, P<0.001) groups. Conclusions When controlling for the type of tissue expander as a confounding factor, HFS was associated with reduced operation time. Furthermore, it demonstrated superior clinical effectiveness compared to BES regarding operator convenience.

No abstract available.

Effects of ketamine on the cardiovascular system of tortoises was observed in this study. Ketamine elevated blood pressure and increased contractile performance and heart rate of the tortoise's auricle. The hypertensive effect of ketamine was abolished by treatment with hexametbonium or Regitine, while increment of heart rate due to ketamine was not affected by treatment of hexamethonjum, Inderal, or Regitine. In vitro experiments, ketamine increased contractile performance and heart rate of the auricle. These effects of ketamine were not affected by Regitine, Inderal,cocaine, or reserpine pretreatment. Synergism of ketamine and norepinephrine was also observed. Low bath temperature did not influence the effects of ketamine but high bath temperature inhibited the effects of the drug. In the electrically stimulated preparations, field stimulation did not affect the chronotropic and inotropic effects of ketamir, but direct stimulation abolished these effects of the drug. From the above results, it is possible to say that ketamine probably has dual actions on the cardiovascular system of tortoises, i, e., hypertensive action due to stimulation of sympathetic nervous system, and chronotropic and inotropic actions due to direct stimulation of cardiac muscle.
Baths ; Blood Pressure ; Cardiovascular System* ; Heart Rate ; In Vitro Techniques ; Ketamine* ; Myocardium ; Norepinephrine ; Phentolamine ; Propranolol ; Reserpine ; Sympathetic Nervous System

False aneurysm has been recognized for many years. Incomplete severance of an artery as the result of trauma is thought to be the precipitating factors in the formation of false aneurysm. False aneurysm of the peripheral artery is presented with pulsating mass and may show extrinsic indentations of the adjacent bone with or without neurovascular symptoms, mimicking a malignant tumor. But careful history taking can reveal a proceeding deep penetrating injury variable period prior to development of symptoms. We are reporting two cases of false aneurysm of the superior gluteal artery and superficial femoral artery in each after trauma.
Aneurysm, False ; Arteries ; Femoral Artery ; Precipitating Factors

PURPOSE: Mycophenolate mofetil (MMF) has been used widely due to lesser acute rejection episode, better renal function and graft survival than azathioprine (AZA). But currently, there is controversy that which combination of immunosuppressants is most beneficial and cost-effective for renal transplant, because some authors reported MMF was related to more infectious complications and no actual superiority to AZA in aspect of graft survival. So, the aims of this study is to compare the long term outcome of renal transplants and the infectious complications between two groups treated with AZA and MMF in CSA based immunosuppressant treatment at our hospital. METHODS: We retrospectively reviewed allograft recipients who had been transplanted from January of 1998 to July of 2000. 301 patients were enrolled (AZA=150/MMF=151) and analyzed for the incidence of acute rejection, infectious complication, renal function and graft survival. RESULTS: Patients treated with MMF had fewer episodes of acute rejection (AR) within 3 months; 4/151 (2.6%) in MMF versus 15/150 (10%) in AZA (P=0.017), but after 3 months there was no difference in the incidence of AR. However, the patients treated with MMF had more infectious complications such as pneumonia, cytomegalovirus (CMV) infection, but there were no differences in urinary tract infection. There were also no differences in creatinine level at postoperative 1 week, discharge, 1 year, 3 year and 5 year. Graft survival and patient survival after 1 year and 5 showed no statistical differences between two groups. CONCLUSION: MMF combined with CsA was more effective in the prevention of acute rejection within 3 months than AZA, but there was no long term significant difference in renal function, graft and patient's survival. Due to higher incidence of pneumonia and CMV infection in MMF group, it is necessary to choose the combination of immunosuppressants (AZA versus MMF) more appropriately considering efficacy of immunosuppression and infectious complication as well.
Allografts ; Azathioprine* ; Creatinine ; Cytomegalovirus ; Follow-Up Studies* ; Graft Survival ; Humans ; Immunosuppression ; Immunosuppressive Agents ; Incidence ; Pneumonia ; Retrospective Studies ; Transplants ; Urinary Tract Infections

Roberts syndrome is an autosomal recessive disorder accompanied by limb defects, craniofacial abnormalities, pre-and postnatal growth retardation. Patients with Roberts syndrome have characteristic premature separation of heterochromatin of many chromosomes and abnormalties in celldivision cycle. We have experienced a case of Roberts syndrome in an immature neonate The patients showed characteristic clinical features of multiple, severe facial mid-line clefts, and tetraphoco-amelia. The brief review of the literlature was made.
Craniofacial Abnormalities ; Ectromelia ; Extremities ; Heterochromatin ; Humans ; Infant, Newborn

No abstract available.
Pancreatitis*

PURPOSE: To evaluate accuracy of magnetic resonance(MR) imaging for staging of lung cancer and to compare the accuracies of CT and MRI. MATERIALS AND METHODS: We retrospectively analyzed 25 cases of lung cancer, which were confirmed surgically and pathologically. Five experienced radiologists participated in the receiver operating characteristic (ROC) analysis to evaluate and compare accuracies of the CT and MR imaging in preoperative staging of non small cell lung cancer by assessing tumor invasion of bronchus, mediastinum, chest wall, and hilar or mediastinal lymph node metastasis. Imaging results were evaluated against "truth" data based on both surgery and pathologic examination. RESULTS: Sensitivity of CT in distinguishing T3-T4 tumors was 60% ;specificity was 76%. These values for MR imaging were not significantly different(53% and 72%). With ROC analysis, no difference existed between accuracies of CT and MR imaging in diagnosis of bronchial involvement, but MR imaging was significantly more accurate than CT(p<0.05) in diagnosis of mediastinal invasion. There was no significant difference between accuracies of CT and MR imaging in detecting mediastinal node metastasis(N2 or N3); sensitivities were 64% and 78%, respectively, and specificities were 64% and 66%. CONCLUSION: There was no significant difference in accuracies of CT and MR imaging in preoperative tumor classification and assessment of mediastinal node metastasis, but MR imaging was more accurate than CT in assessment of mediastinal invasion.
Bronchi ; Carcinoma, Bronchogenic* ; Classification ; Diagnosis ; Lung Neoplasms ; Lymph Nodes ; Magnetic Resonance Imaging* ; Mediastinum ; Neoplasm Metastasis ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Small Cell Lung Carcinoma ; Thoracic Wall

PURPOSE: To evaluate accuracy of magnetic resonance(MR) imaging for staging of lung cancer and to compare the accuracies of CT and MRI. MATERIALS AND METHODS: We retrospectively analyzed 25 cases of lung cancer, which were confirmed surgically and pathologically. Five experienced radiologists participated in the receiver operating characteristic (ROC) analysis to evaluate and compare accuracies of the CT and MR imaging in preoperative staging of non small cell lung cancer by assessing tumor invasion of bronchus, mediastinum, chest wall, and hilar or mediastinal lymph node metastasis. Imaging results were evaluated against "truth" data based on both surgery and pathologic examination. RESULTS: Sensitivity of CT in distinguishing T3-T4 tumors was 60% ;specificity was 76%. These values for MR imaging were not significantly different(53% and 72%). With ROC analysis, no difference existed between accuracies of CT and MR imaging in diagnosis of bronchial involvement, but MR imaging was significantly more accurate than CT(p<0.05) in diagnosis of mediastinal invasion. There was no significant difference between accuracies of CT and MR imaging in detecting mediastinal node metastasis(N2 or N3); sensitivities were 64% and 78%, respectively, and specificities were 64% and 66%. CONCLUSION: There was no significant difference in accuracies of CT and MR imaging in preoperative tumor classification and assessment of mediastinal node metastasis, but MR imaging was more accurate than CT in assessment of mediastinal invasion.
Bronchi ; Carcinoma, Bronchogenic* ; Classification ; Diagnosis ; Lung Neoplasms ; Lymph Nodes ; Magnetic Resonance Imaging* ; Mediastinum ; Neoplasm Metastasis ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Small Cell Lung Carcinoma ; Thoracic Wall