Pancreatic cancer has the highest mortality among malignant cancers. Known asthe king of cancer,it lacks early symp-toms, diagnostic methods and oncologic markers. Early lymph node metastasis could be found in this disease. Moreover, advanced panereatic cancer is incurable by surgery. Due to the limited efficacy of surgery, as well as radiotherapy and chemotherapy tolerance, therapeutic methods for pancreatic cancer are being explored. L1 cell adhesion molecule (L1CAM) is a member of the cell adhesion molecule inmunoglobulin (Ig) super family that is usually expressed in normal developing nervous tissues. L1CAM is highly expressed in pancreatic cancer cells, binds withα5-integrin to activate downstream factors that mediate tumor metastasis and invasion via the TGF-β1/JUK/slug signaling pathway, induces epithelium-mesenchymal transition, and resists chemotherapy drugs. However, L1CAM forms abnormal vessels that increase the invasiveness of pancreatic cancer cells. This abnormal L1CAM expression in pancreatic can-cer cells is a new therapeutic target in pancreatic cancer treatment. Therefore, future studies on L1CAM could promote the develop-ment of pancreatic cancer therapy and provide new treatment methods.

Intracranial aneurysm is a common disorder. With the ongoing improvement of medical imaging technique, the chance of finding an unruptured intracranial aneurysm in clinical practice has steadily increased. The rupture of aneurysms can result in subarachnoid hemorrhage and even in life-threatening conditions. Recent researches have indicated that the rupture risk of intracranial aneurysms bears a close relationship to the aneurysm's features, such as the size, site, shape, number, growth orientation, growth rate, etc. A further understanding of the features of unruptured intracranial aneurysm is very valuable for the effective prevention of its rupture.

Purpose:To observe the efficacy of capecitabi ne combined with the transcatheter arterial chemoembolization (TACE) in late-stag e primary hepatic carcinoma.Methods:62 patients of late-stage hepatic carcinoma (TNM: Ⅱ- Ⅳ) were divided into two groups at random:①Simple TACE group: 30 cases;②capec itabine+TACE group:32 cases were given additional oral capecitabine for 14 days the next day after TACE therapy. All the patients were followed for two years.Th e median survival time, the average survival time of dead patients, the 1-year survival rate and the second-stage surgical resection rate of the two groups we re compared. Results:The median survival time of capecitabine+TACE group was 14.5 months, the 1-year survival rate 75%, the second-stage surgical resectio n rate 25%; the TACE group was 6 months,39.3%,6.7% ,respectively. The difference was significant (P

Objective The aim of our study was to describe the clinicopathological characteristics and to evaluate the prognostic factors of postoperative PNENs.Methods The clinicopathological data of 101 postoperative PNENs patients were collected and analyzed retrospectively.We analyzed the clinicopathological characteristics and prognostic factors.The survival analysis was conducted by Kaplan-Meier method and survival analysis was performed by Cox model.Results 101 patients with PNENs were enrolled,including 46.5％ male(n=47) and 53.5％ female(n=54),the median age was 51 years old (ranged 19-80).94 patients(93.1％) with neuroendocrine tumors(NETs),7 patients(6.9％) with neuroendocrine carcinomas(NECs).The mean size of tumor was 3.3 cm(ranged 0.5-15).Immunohistochemistry staining positive rates for chromogranin A (CgA) and synaptophysin (Syn) were 89.0％ and 98.0％ respectively.Patients were 66 cases (65.3％),23 cases (22.8％) and 12 cases (11.9％) in TNM stage I,II and IV respectively.34 cases(33.7％) were F-PNENs,and 67 cases(66.3％) were NF-PNENs.Our study demonstrated that there were statistically significant differences between F-PNENs and NF-PNENs in stage,grade,neural and vascular invasion,CgA positive rate(χ2=10.372,18.162,9.699,5.547,4.043,P＜0.05).Meanwhile,significant differences were found between NETs and NECs in stage,neural and vascular invasion,CgA positive rate(χ2=11.642,5.254,14.458,5.254,P＜0.05).PNENs had better prognosis,with 5-year survival rate of 84.3％.The independent prognostic factor for survival was grade.Conclusion PNENs are a family of tumors with diversity clinical presentation and prognosis.Surgery is the main treatment method,grade of PNENs is the independent prognostic factor.

Objective To study the effects of ?-asarone on mitochondrial membrane potential(MMP) of cardiac myocytes with ischemia reperfusion injury. Methods The cardiac myocytes model of myocardial ischemia reperfusion injury (MIRI) was induced with sodium dithionite (Na2S2O4). The primary cultured cardiac myocytes of SD neonatal rats were randomized into six groups:normal group,model control group,high-dose ?-asarone (25 ?g/mL),middle-dose ?-asarone group(12.5 ?g/mL),low-dose ?-asarone group (6.25 ?g/mL) and medium group. Mitochondrial membrane potential(MMP) of myocardial cells were measured by flow cytometry. Results Compared with the normal group,MMP in the model control group was obviously decreased(P

Objective To study the protective effects of ?-asarone against the myocardial ischemia/ reperfusion injury (MI/RI) in cultured cardiac myocytes. Methods MI/RI model was set up with Na2S2O4, which make use of rat cardiac myocytes. The viability of cardiac myocytes (using MTT method), dehydrogenase (LDH, CK) activitices in the medium were measured. Results In MI/RI model, ?-asarone can obviously advance the viability of cardiac myocytes, and decrease the dehydrogenase (LDH, CK) activitices in the medium. Conclusion ?-asarone showed protective effects against the myocardial ischemia/reperfusion injury in cultured cardiac myocytes.

Tumor necrosis factor-α (TNF-α)is a kind of cytokines with a wide range of biological activity,which is closely related to the occurrence and development of various diseases.Nowadays,a number of researchers use TNF-α as a radiation-sensitizing agent to evaluate the effect of radiation sensitivity of tumor cells.The scheme may have correlation with cell apoptosis,cell cycle,hypoxic cells,repair of DNA damage,etc.

Objective To observe the various influence of Imipenem/Cilastatin(IPM) and Cefoperazone(CPZ) on Gram-negative bacterial endotoxin release in severely burned patients.Methods Patients were divided into IPM group and CPZ group randomly. The bacterial cultures and microbial drug-sensitivities of burn wound swabs and subeschar tissues were performed on the 1st and 3rd day, At the same time, the levels of LPS in plasma were detected in seven burned patients administrated with IPM and six with CPZ at the time 0?2?4?12?24?48?72h of antibiotics administration.Results Patients were infected by Gram-negative bacterial. The counting of bacteria in subeschar tissues decreased 10~100 times after the administration of antibiotics 3 days; Plasma LPS levels elevated to the peak value at 2h after infusion of IPM or CPZ , and then showed significant decrease. The magnitude of increased LPS in CPZ group was higher than that in IPM group; The LPS levels of 72h were lower significantly than that of 0h.Conclusion IPM and CPZ could effectively control Gram-negative bacterial infection and induce the releases of LPS from bacteria, of which the former induced less LPS release than the latter; The levels of LPS came down with the decreasing of bacterial counting.

Objective To evaluate risk factors of hepatitis B virus (HBV) reactivation after transarterial chemoembolization (TACE) in patients with HBV-related hepatocellular carcinoma (HCC) with undetectable HBV DNA levels.Methods From August 2012 to Sepemter 2015,all patients who underwent TACE for HBV-related HCC with HBV DNA level less than 103 copies/ml in the First Affiliated Hospital of Soochow University were enrolled into the study.These patients were followed-up for at least 6 months after TACE to assess HBV reactivation.Univariate and multivariate logistic regression analyses were done to evaluate the risk factors related to HBV reactivation in these patients.Results With predetermined inclusion and exclusion criteria,99 patients were enrolled into the study.Twenty-four patients (24.2％) developed HBV reactivation after TACE in the followed-up period.The level of transaminase was significantly higher in the HBV reactivation group than the non HBV reactivation group (P ＜ 0.05).HBeAg positivity and tumors more than 3 in number were independent risk factors of HBV reactivation.Conclusion HCC patients with undetectable levels of HBV DNA had a significant risk of HBV reactivation after TACE.

Objective To build a digitized 3D model of the pulmonary venous system of Chinese people for the purpose of providing anatomic information of the pulmonary venous system for anatomic teaching,imaging diagnosis and surgical operation of pulmonary diseases. Methods The primal images from the first Chinese visible human data set of chest were converted into image sequence only cantaining the sections of pulmonary veins after manual registration and image segmentation.Then these images were imported into 3DMed software to build a 3D model of the pulmonary venous system through threshold registration algorithm. Results The three dimensional structures of the pulmonary venous system were reconstructed entirely.All reconstructed structures could be displayed individually or jointly,and could be rotated continuously on any plane.Conclusion The branches and the spacial characters of the pulmonary venous system can be clearly shown on the reconstructed 3D model.It will help anatomy teaching and provide morphological data for image diagnosis and lung operations.