1.Research Advances on CD47 Molecules in Tumor Microenvironment of Diffuse Large B-cell Lymphoma
Yiyue LIU ; Yanyu SU ; Geng LYU ; Zizhen XU
Cancer Research on Prevention and Treatment 2023;50(6):616-621
Diffuse large B-cell lymphoma (DLBCL) is a common, highly aggressive and heterogeneous hematologic malignancy in adults. Patients with DLBCL have substantially differences in molecular biological characteristics, clinical manifestations, and prognosis. Increasing evidence shows that the tumor microenvironment plays an important role in the occurrence and development of DLBCL. CD47, an integrin related protein, is overexpressed in DLBCL cells and plays a key role in immune escape of lymphoma. This work reviews the research progress of CD47 in DLBCL TME in terms of CD47-related signal pathway, CD47 role in DLBCL TME, and therapeutic strategies targeting CD47 in DLBCL TME.
2.Mechanisms of ferroptosis and its significance in breast cancer therapy
Yiyue XU ; Shaorong ZHAO ; Jingjing LIU ; Jin ZHANG
Journal of International Oncology 2020;47(6):372-376
Breast cancer is a malignant tumor originating from breast epithelial tissue. Ferroptosis is a novel type of programmed cell death which differs from apoptosis and necrosis. Research found that the accumulation of lipid peroxides in cells, a crucial process of ferroptosis, can be induced by multiple mechanisms. The ferroptosis regulation is closely related to the occurrence and development of breast cancer, and it induced by drugs is a potential and valuable research direction in breast cancer.