The BUB1 mitotic checkpoint serine/threonine kinase B(BUB1B)maintains a high fidelity of mitotic chromosome segregation by preventing the initiation of anaphase without the attachment of one or more kinetochore to the spindle,and plays a major role in both signal transduction and the stable attachment of kinetochore to micro-tubules.The dysregulated expression of BUB1B may affect the occurrence of mitosis-induced aneuploidy,chromo-some instability and abnormal cell biological function,leading to cell malignant transformation.This review summa-rizes the role of BUB1B in the occurrence and development of gynecological malignant tumors.