Objective? To investigate and analyze the domestic and oversea studies on heart failure symptom clusters through a bibliometric analysis, and provide evidence basis for future clinical nursing research. Methods? The CNKI the Wanfang Science and Technology Journal Full-text Database, the China Biomedical Literature Database (CBM), the PubMed, and the Web of Science database were searched for the articles both in Chinese and English about heart failure symptom clusters published from database establishment dates to August 31st, 2018 and analyzed on their published years, distribution of journals, and research content. Results? A total of 21 articles complied with the standard were retrieved with the first published article dated back to 2009. Among them, there were 13 cross-sectional studies, 4 longitudinal studies, 3 reviews, and 1 tool development. Although different studies had differences in research design, sample characteristics, assessment tools, and analytical methods, the main findings were basically the same: somatic symptom cluster and emotional symptom cluster were common symptom clusters in patients with heart failure; somatic symptom cluster mainly included shortness of breath, dyspnea, fatigue, declined physical strength, dyscoimesis; emotional symptom cluster mainly included anxiety, depression, cognitive disorder; there was still controversy about the classification of edema. Conclusions? At present, the research on heart failure symptom clusters in China and abroad is still at the initial exploration stage, and the research results are still unstable. In the future, we can further develop long-term dynamic observation of heart failure symptom clusters and explore corresponding symptom management strategies.

Pancreatic cancer,as a common malignant tumor of the digestive system,has a very low survival rate.In recent years,pancreatic cancer has made great progress in diagnostic methods,radiation therapy techniques,and systemic chemotherapy,but its therapeutic effect has not been considerably improved.As a new type of tumor research platform,organoids have made research progress in many fields.Constructing pancreatic cancer organoids is of great research value to guide the individualized treatment of pancreatic cancer.This article reviews the research and clinical application prospect of organoid model in radiotherapy of pancreatic cancer.

Objective To evaluate the clinical application of TCM nursing therapies and identify the problems during the therapy implementation, in order to explore the countermeasures to promote its clinical improvement. Methods A descriptive cross-sectional study was conducted,and a self-designed questionnaire was employed to investigate 218 nurses from 148 grade A class three TCM hospitals in China. Results 25 TCM nursing therapies were implemented in these hospitals. Ear acupressure therapy was the most frequently implemented,accounting for 83.5%(182/218);while wax therapy was the least implemented, accounting for 7.8%(17/218). The implementation frequency of these technologies varied significantly, 0~860 times a week. The top three of them were acupoint application therapy, hot compression of Chinese medicine and ear acupoints therapy.TCM nursing therapies were considered to be the most frequently used in insomnia, headache, edema, arthralgia, cold, epigastric pain, hypochondriac pain and fever.Storage of TCM nurses,lacking of TCM knowledge and inapposite therapy implementation were the main problems in the application. Conclusions Scientific and rational allocation of human resources, cultivation of the TCM-specific nursing professional, enhancement of nurses'awareness of Chinese medicine, establishment of a reasonable charging standard, and strengthening the risk management in implementation will promote its clinical development.

The collection， screening， weighting， and comprehensive evaluation of indicators are key steps in establishing the effectiveness evaluation index system of traditional Chinese medicine （TCM）. This article systematically reviewed the research methods in different stages， explored their existing problems， and provide reflections and recommendations. For indicator collection， literature research and expert interviews are generally used， but patient participation is not sufficient； for indicator screening， the Delphi method is the most widely used method， but there is still a lack of criteria and evidence to support indicator screening， and a few studies have applied clinical investigation methods； for indicator weighting， including subjective weighting and objective weighting， but they are mostly the application of a single type of method， and the indicator weights lack reliability； for comprehensive evaluation， analytic hierarchy process， TOPSIS， fuzzy comprehensive evaluation， rank sum ratio， the fuzzy-hierarchy technique for order preference by similarity to an ideal solution， grey relational analysis， and data envelopment analysis have gradually been applied to the study of TCM effectiveness evaluation， however， they often reflect the short-term effectiveness of TCM and can not highlight their long-term effectiveness advantages. Therefore， it is necessary to strengthen the participation of patients and consider their perspectives； in the process of selecting indicators， evidence support for importance judgments should be provided to experts； in indicator weighting， we should integrate subjective and objective data information and actively carry out research on optimizing combination weighting methods； finally， a disease information management platform could be established and a dynamic comprehensive evaluation model could be constructed to provide new ideas and methods for evaluating the effectiveness of TCM.