Objective: To investigate application effect of collaborative care model on self?cre ablilioy in patients with craniocere?bral trauma in recovery period. Methods: A total of 96 patients with craniocerebral trauma in recovery period were randomly divided into experimental group and control group ( n=48) . Control group received the routine nursing methods. The experimental group re?ceived collaborative care model on the basis of routine nursing methods. Self care ability scale ( ESCA) was used to evaluate self?care ability in two groups before and after the intervention. Results: There was no statistical significance in self?care ability before inter?vention in two groups ( P>0?05) . Self?care skills, personal responsibility, self concept and health knowledge levels in the experi?mental group after intervention were significantly higher than those in the control group ( P<0?01) . Conclusion: Collaborative care model used in patients with craniocerebral trauma in recovery period can solve a variety of health problems, improve the training effect, and improve the level of self?care ability.