1.Regulation of Acupuncture on Experimental Insulin Resistance in Rats
Jian SUN ; Nenggui XU ; Wei YI ; Yixu DU
Journal of Guangzhou University of Traditional Chinese Medicine 1999;0(02):-
【Objective】To observe the regulation of acupuncture on experimental insulin resistance in rats and to investigate the influence of diet during the acupuncturing.【Methods】Forty rats were equally randomized into blank group,model 1 group,model 2 group,acupuncture 1 group and acupuncture 2 group.Rat models with insulin resistance were induced by feeding forage of high fat,sugar and salt.After the models were induced successfully,blank group was still fed with normal forage,model 1 group still with forage of high fat,sugar and salt,model 2 group with normal forage instead,acupuncture 1 group still with forage of high fat,sugar and salt for 2 weeks and acupuncture 2 group with normal forage instead.Meanwhile,acupuncture 1 and 2 groups received acupuncture once a day.The changes of fasting plasma glucose(FPG),plasma insulin(INS),insulin sensitivity index(ISI),serum Cpeptide(C-P) and the ratio of INS and C-P were observed after treatment.【Results】FPG,INS,C-P and INS/C-P were increased and ISI decreased in model 1 group as compared with the blank group(P
2.Effect of Electroacupuncture on the Synaptic Number Density and Surface Density in the Cerebral Ischemic Areas of Rats with Focal Cerebral Ischemia at Different Time
Yixu DU ; Nenggui XU ; Wei YI ; Guoxin HUANG ; Tong CAI ; Zhenyan HUANG ; Lingni WU ;
Journal of Guangzhou University of Traditional Chinese Medicine 2001;0(03):-
Objective To investigate the effect of electroacupuncture(EA)in improving the reconstruction of synapse after cerebral ischemia.Methods Forty-five Wistar rats were divided into 3 groups:sham-operated group,ischemia group and EA group.The number density(Nv)of synapses and the surface density(Sv)of synaptic joint band were observed 1 hour,1 day,3 days,1 week and 3 weeks after ischemia and EA, respectively.Heat-coagulation-induced occlusion of the middle cerebral artery was performed to establish the model of focal cerebral ischemia.EA group received EA on the acupoints of Baihui and Dazhui.The changes of synaptie structure,Nv and Sv as well as the influence of EA on the above indexes were observed in different time.Results There existed significant decrease of Nv and Sv 1 hour,1 day and 3 days after establishment of models in the isehemia group(P0.05).Conclusion EA can reduce the cerebral ischemic injury by increasing the synaptic amount and area in the cortex of rat model of cerebral isehemia at early stage,promoting the cerebral recovery after ischemia,which will provide substantial morphological basis for the improvement of synaptic reconstruction and recovery from cerebral isehemia by EA at different time after ischemic cerebral injury.