The acute ischemic stroke has become the first major disability and death disease in China.With the release of the results of five trials represented by the Dutch multicenter randomized clinical trials of intravascular treatment of acute ischemic stroke, mechanical thrombectomy has become the main means to treat the acute ischemic stroke caused by the occlusion of large intracranial vessels, ushering in a new era of mechanical thrombectomy for acute cerebral infarction.At present, the main devices of mechanical thrombectomy are Merci thrombectomy device, penumbra thrombectomy device, solitairetm fr stent, revive se stent, trevo stent and aperio ® stent.According to the location and conditions of vascular embolism, different types of thrombectomy devices should be selected, and different thrombectomy technologies, such as adapt technology, solumbra Technology, advance technology, save technology, swim technology, etc So as to improve the recanalization rate and reduce complications.

Objective? To explore the effects of Pediatric Early Warning Score (PEWS) nursing record template on pediatric pneumonia. Methods? The medical records of totally 40 pediatric pneumonia patients admitted between June and December, 2017 in the Department of Respiratory Medicine of a Class Ⅲ Grade A children's hospital were selected into the observation group, while the medical records of another 40 pediatric pneumonia patients admitted between June and December 2016 were selected into the control group by random sampling. The medical records of the control group were written in accordance with the Medical Record Writing Standards of Anhui Province (Version 2013), whereas the medical records of the observation group were written using the PEWS nursing record template. The nursing document quality scale of the two groups was viewed, and objectivity, expression of the specialty and misuse of medical terms were compared between the nursing records of the two groups; the time used to write the nursing records by nurses with different length of service was compared. Results? Totally 35 errors in objectivity, expression of the specialty and use of medical terms were found in the nursing records of the observation group, while those of the control group was 211, and there was statistically significant difference between the two groups (χ2=12.81, P＜0.05). Conclusions? The use of PEWS nursing record template can reduce the errors in the nursing records of pediatric inpatients, improve the quality of nursing documents, and save the time of writing nursing records for nurses, which is worth promoting in clinical practice.

T cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy. Emerging evidence has shown that interferon-gamma (IFNγ) could enhance CXCL9 secretion from macrophages to recruit T cells, but Siglec15 expressed on TAMs can attenuate T cell proliferation. Therefore, targeted regulation of macrophage function could be a promising strategy to enhance cancer immunotherapy via concurrently promoting the infiltration and proliferation of T cells in tumor tissues. We herein developed reduction-responsive nanoparticles (NPs) made with poly (disulfide amide) (PDSA) and lipid-poly (ethylene glycol) (lipid-PEG) for systemic delivery of Siglec15 siRNA (siSiglec15) and IFNγ for enhanced cancer immunotherapy. After intravenous administration, these cargo-loaded could highly accumulate in the tumor tissues and be efficiently internalized by tumor-associated macrophages (TAMs). With the highly concentrated glutathione (GSH) in the cytoplasm to destroy the nanostructure, the loaded IFNγ and siSiglec15 could be rapidly released, which could respectively repolarize macrophage phenotype to enhance CXCL9 secretion for T cell infiltration and silence Siglec15 expression to promote T cell proliferation, leading to significant inhibition of hepatocellular carcinoma (HCC) growth when combining with the immune checkpoint inhibitor. The strategy developed herein could be used as an effective tool to enhance cancer immunotherapy.