Metoclopramide (MCP) stimulating test for prolactin (PRL) secretion was performed on 5 normally cycling women (early follicular phase, EF), 4 early puerperal women and 17 patients with galactorrhea and anovulation. The mean serum PRL level in EF group increased more than 7-fold of the mean basal PRL level after MCP injection but only 1.51 and 1.28 times of that in postpartum and galactorrhea-anovulation groups respectively. However, no significant difference was noted between the pituitary tumor and non-tumor groups, thus MCP stimulating test for PRL secretion was not helpful to differential diagnosis between functional hyperprolactinemia and microprolactinoma. The relationship and management of these two clinical entities were also discussed.

Objective To investigate the clinical effect of modified seton therapy with counterparts drainage on high anal fistula.Methods One hundred and forty-four patients with high anal fistula were randomly assigned to the observed group (modified seton therapy with counterparts drainage,74 cases) and the control group (the traditional high hanging line therapy,70 cases).The clinical efficacy,visual analogue scale (VAS),Wexner incontinence score,fecal incontinence quality of life index (FIQLI) score were compared.Results Observed group were cured with 40 cases,improved with 27 cases,ineffective with 7 cases,control group were cured with 25 cases,improved with 43 cases,ineffective with 2 cases,difference between two groups was statistically significant (P ＜ 0.01).The healing time in observed group was significantly shorter than that in control group(P＜ 0.01).The VAS after therapy 1,7 d in observed group was significantly lower than that in control group (P ＜ 0.05).The Wexner incontinence score,FIQLI score before therapy was no significant difference between two groups (P ＞0.05).The Wexner incontinence score,FIQLI-lifestyle score,FIQLI-depression/self-perception score,FIQLI-distress score after therapy 3 months in observed group was significantly higher than that before therapy and control group after therapy 3 months (P ＜ 0.05),there was no significant difference Wexner incontinence score and FIQLI score before therapy compared with therapy 3 months in control group (P ＞ 0.05).Conclusions Modified seton therapy with counterparts drainage may be a valid treatment for high anal fistula.The successful outcome is associated with significant improvement in quality of life.

Ten years had passed for the molecular targeted therapy since approval by the U.S.Food and Drug Administration of the first monoclonal antibody-Rituximab,for the treatment of the B-cell non-Hodgkin's lymphomas with positive CD20- The targeting therapy,which may be a promising approach in the future,has significantly improved the patients'qualities of lives and prognosis because it has higher selectivity and less adverse effects than current chemotherapy and radiotherapy.In the past decade,with the fast development of novel targeting drugs and extension of therapeutic fields,the limitations associated with the targeted treatments were received attentions.

Objective: To explore the effect of perfectionism on depression using anxiety as a controllng variable,and to find possible personality moderators.Methods: 407 undergraduate students from 8 universities in Beijing and Xi'an completed a battery of questionnaires,including Frost Multidimensional Perfectionism Scale(FMPS),Beck Depression Inventory(BDI),Personality Adjective Checklist(PACL) and Self-rated Anxiety Scale(SAS).Results: Hierarchical Regression Analysis confirmed the effects of two negative perfectionism dimensions hesitating over actions and concerning over mistakes,on depression after controlling anxiety.The effect of organization on depression was moderated by the personality trait of cooperation.Conclusion: Dimensions of perfectionism have diverse effects on depression.Psychological intervention should be carried out according to individual characteristics.

Objective: To examine the reliability and validity of MBI-SS and discuss the academic characteristics that affect burnout. Methods: 353 undergraduate students were administrated MBI-SS and Academic Characteristic Survey. Results: Confirmatory factor analyses showed that the expected three-factor structure of the adapted versions of the MBI- Students Survey (including Exhaustion, Cynicism, and Reduced Efficacy) fitted to the data. Exploratory factor analyses showed that the Academic Characteristic Survey includes six dimensions. The result of Regression showed that 44.4% variance of student burnout can be explained by Academic Characteristics. Conclusion: Student burnout includes three dimensions: Exhaustion, Cynicism and Reduced efficacy. Academic self-efficacy,academic stress,relationship with teachers and relationship with fellow students are significant predictors for student burnout.

Objective To discuss the influence of Danshen Chuanxiongqin injection on renal function and relevant indexes of urine in rats with sepsis -induced acute kidney injury(AKI))caused by cecal ligation and punc-ture (CLP).Methods Seventy male Sprague Dawley(SD)rats were randomly divided by random number table into normal group,sham -operation group,sepsis group and Danshen Chuanxiongqin group.The three latter groups were divided into groups of 6,12,24,48 -hour subgroups,five rats in each subgroup.Danshen Chuanxiongqin group was injected with Danshen Chuanxiongqin injection at 0,24,48h from caudal vein seperately,and the other groups were injected with saline solution.The blood and urine were collected in the set four time points.The relevant indexes like serum creatinine (SCr),blood urea nitrogen(BUN),IL -6 and TNF -αwere tested and kidney injury molecule -1 (KIM-1)and neutrophil gelatinase associated lipocalin (NGAL)were detected.Changes of renal pathology were observed under light microscope.Results In the sepsis group,the concentrations of SCr and BUN 6h after CLP star-ted to rise,reached peak in 24h to (96.31 ±12.64)μmol/L and (27.17 ±4.98)mmol/L,and decreased in 48 h, while concentrations of IL -6 and TNF -αwere reached peak in 12h (28.45 ±3.22)pg/mL and 6h (72.35 ± 10.84)pg/mL respectively,and then decreased,which were all higher than those in the normal group and sham -operation group (P <0.05).After Danshen Chuanxiongqin injection therapy,the concentrations of Scr,BUN,IL -6 and TNF -αin 6h,12h,24h and 48 h were all lower than those in the corresponding points in time in the sepsis mod-el group,and reached minimum values[(14.89 ±2.41)μmol/L,(17.29 ±3.37)mmol/L,(14.89 ±2.41)pg/mL, (17.29 ±3.37)pg/mL,all P <0.05].The contents of KIM-1 and NGAL 6 h after CLP started to increase,reached peak in 24h (5.47 ±0.39)ng/mL and 12h (6.35 ±0.81)ng/mL respectively,and decreased in the sepsis group were all remarkably higher than those in the normal group and sham -operation group.After given Danshen Chuanx-iongqin injection,the contents of KIM-1 and NGAL in 6h,12h,24h and 48h were greatly lower than those in the corresponding points in time in the sepsis group,reached minimum values[(2.27 ±0.16)ng/mL,(2.03 ±0.27)ng/mL,all P <0.05)].In the Danshen Chuanxiongqin group,the change of renal pathology was better than that of the sepsis group in 12h.Conclusion Danshen Chuanxiongqin injection plays the role of renal protection in AKI caused by sepsis.

Objective To explore conduct disorder tendency and it's influence factors on secondary school students. Methods 669 students of grade 1 in Dezhou Vocational and Technical College were investigated by Conduct Disorder Tendency Questionnaire, Revised Version of MBI-SS and SRHMS Version1.0. Results The secondary vocational school students' scores on violation tendency, addiction tendency and aggression tendency were 11.51±4.08,5.90±2.68 and 6.68±2.63,and were significant different from vocational college students or high school students(addiction tendency:F(2, 1578)=7.48,P =0.001;aggression tendency:F(2, 1579)=24.40,P <0.001). There existed great capable difference of conduct disorder according to genders ( t(643)>3.85,P <0.001).Conduct disorder tendency of secondary vocational students' was positive correlated with their learning burnout (Pearson correlation coefficient was between 0.16 and 0.52 for each pair), but negative correlated with mental health(Pearson correlation coefficient was between -0.13 and -0.27 for each pair). The linear regression showed that some dimensions of learning burnout and self-rated mental health predicted students' conduct disorder tendency. Conclusion Conduct disorder tendency of secondary vocational students is affected by their learning burnout and mental health.

Objective: To study the relationship between maternal behavior and behavior problem of their children Method: 765 mothers with children aged 6 to 11 were assessed with MBQ (maternal behavior questionnaire) and behaviors of their children were assessed with CBCL (Achenbach children's behavior checklist) Results: 12 0% of children was identified as having behavior problems Maternal supportive behavior decreased behavior problems of their children, while maternal un-supportive behavior increased that Conclusion: Maternal behaviors had a significant effect on children's behavior problem

ObjectiveTo explore the value of three-dimensional speckle tracking (3DT-STI) technique for evaluating end-systolic three-dimensional longitudinal strain (3DLSe) of left ventricular myocardium in patients with left anterior descending coronary artery (LAD) lesions.MethodsSixty patients with pure LAD lesions diagnosed by coronary artery angiography (CAG) in Taizhou Hospital from June 2012 to December 2014 were enrolled, including 30 patients with acute anterior wall myocardial infarction (infarction group) and 30 patients without acute anterior wall myocardial infarction (non-infarction group). Sixty patients in the control group were enrolled in Department of cardiology in Taizhou Hospital in the same period. 3DLSe within LAD blood-supplied region, adjacent region and remote region were analyzed in all cases using 3DT-STI. The 3DLSe differences of 3 groups were compared by one-way analysis of variance, and the 3DLSe differences between two groups were compared by the LSD-t test. The inter-observer and intra-observer consistency of 3DLSe of left ventricular myocardium were analyzed by Bland-Altman drawing analysis method.Results3DLSe of all 7 segments within LAD blood-supplied region were lower in infarction group than those of non-infarction group and control group, and the differences were statistically significant (infarction groupvs. control group:t values were 6.96, 7.41, 8.94, 8.23, 8.94, 12.09 and 15.99, respectively,P values were all less than 0.01; infarction groupvs. non-infarction group:t values were 5.30, 5.50, 4.66, 4.32, 4.66, 7.66 and 10.11, respectively, P values were all less than 0.01); 3DLSe of middle anterior segment, middle anterior septal segment, apical anterior segment, apical septal segment and apex of heart within LAD blood-supplied region were lower in non-infarction group than those of control group, and the differences were statistically signiifcant (t values were 3.56, 3.23, 3.02, 3.25 and 4.36, respectively,P values were all less than 0.01), but 3DLSe of basal anterior segment and basal anterior septal segment had no statistically significant difference. 3DLSe of basal inferior septal segment within LAD adjacent region had no statistically significant difference in all 3 groups. 3DLSe of basal lateral segment, middle inferior septal segment, middle lateral segment, apical inferior segment and apical lateral segment within LAD adjacent region were lower in infarction group than those of non-infarction group and control group, and the differences were statistically signiifcant (infarction groupvs. control group:t values were 4.15, 4.79, 4.58, 9.24 and 12.07, respectively,P values were all less than 0.01; infarction groupvs. non-infarction group:t values were 2.66, 3.59, 4.29, 7.74 and 10.33, respectively,P values were all less than 0.01); but 3DLSe of basal lateral segment, middle inferior septal segment, middle lateral segment, apical inferior segment and apical lateral segment within LAD adjacent region had no statistically significant difference between non-infarction group and control group. 3DLSe of all 4 segments within remote region had no statistically significant difference. Bland-Altman drawing analysis method showed the mean inter-observer and intra-observer difference of 3DLSe of left ventricular myocardium were-0.3% and-0.2%, the 95% conifdence interval (CI) were in the range of (-5.6%, 5.0%) and (-8.2%, 7.7%), respectively. It was demonstrated that 3DLSe of left ventricular myocardium had good inter-observer and intra-observer consistency.Conclusions3DLSe of left ventricular myocardium can detect the subtle changes in myocardial systolic function and is more sensitive than the conventional echocardiography. It can localization and analyze quantitatively the range of myocardial ischemia or infarction and has good consistency.

Objective To investigate the prevalence of occupational asthma,airway inflammation and analyze the risk factors for workers exposed to isocyanates.Methods A cross-sectional study was applied.Totally 429 isocyanates exposed workers were surveyed and the prevalence of occupational asthma and airway inflammation situation were examined by questionnaire,physical examination and laboratory tests.Multivariate logistic regression was applied to analyze the possible risk factors of isocyanate-induced occupational asthma.Results (1) A total of 366 patients with complete data were included in the study,and finally 11 cases were diagnosed as isocyanate-induced occupational asthma with a prevalence of 3.0％.(2) Neutrophil percentage in the induced sputum of occupational asthma increased significantly [42.00％ (34.00％-55.00％) before work and 59.00％ (51.00％-70.00％) after work (Z =-2.940.P ＜ 0.05)].(3) Length of service (OR =3.096,P =0.025) and rhinitis (OR =1.901,P =0.008) were independent dangerous factors,and protective measures (OR =0.074,P =0.015) was protective factors to isocyanateinduced occupational asthma.Conclusions Neutrophilic inflammation can be triggered by isocyanate exposure.Regular health examinations,effective protective measures can reduce the prevalence of isocyanateinduced occupational asthma.