Objective To evaluate the anti-oxidant effects of vitamin E -modified membrane in hemodialysis patients.Methods In our four-week study,57 patients on maintenance hemodialysis were divided randomly into three groups.Group A (n=19) resorted to hemodialysis with VitE-modified membrane;Group B (n=19) resorted to hemodialysis with conventional dialyzers and oral VitE intake(400mg/d);Group C (n=19) resorted to hemodialysis with neither vitamin E-modified membrane nor vitamin E intake.Blood samples were collected prior to the first and thirteenth dialysis sessions,and were employed to determine the concentrations of malonylaldehyde (MDA),glutathione peroxidease (GSH-px),glutathione (GSH),superoxide dismutase (SOD) and Vitamin E in plasma and red blood cells (RBC),and advanced oxidative protein products (AOPP) in plasma.Results In group A,there were significant increase in VitE,GSH-px,GSH and SOD levels,and declined MDA and AOPP levels in plasma and in RBC(P0.05).Conclusion Our study suggests that VitE may have anti-oxidant effects on hemodialysis patients,and that VitE-modified membrane may have more advantages in anti-oxidative effect compared with.VitE oral administration.

Objective To understand the prevalence of internet addiction disorder(IAD)and explore its relationship with suicidal tendency of undergraduates.Methods A total of 1517 undergraduates were investigated by using Internet Addiction Scale(IAS),Beck Hopelessness Scale(BHS)and self-made questionnaire.Results The prevalence of lAD was 14.8％.Males,single child,and those at the second grade,with poor performance or higher family income were at a higher risk of internet addiction(P ＜ 0.01).There was significantly positive correlation between internet addiction and suicidal tendency in undergraduates(x2 =76.30,P ＜ 0.01,r =0.40).The risk of suicidal tendency was significantly increased in the high internet addiction score group(OR =12.29,95 ％ CI 6.33 to 23.84).Conclusion Higher prevalence of IAD was found in the undergraduates,which could contribute to the increasing suicide.

Cervical cancer, a common malignant tumor in female reproductive system, seriously threatens women's life and health. The standard surgery for early cervical cancer is radical hysterectomy + pelvic lymphadenectomy±para-aortic lymph node sampling. Lymph node metastasis is an independent risk factor for the prognosis of cervical cancer patients. Several researches showed that the incident of lymph node metastasis in early cervical cancer was approximately 20%. Giving the complications and sequelae of systematic lymph node resection, its application in early cervical cancer is still doubted. The sentinel lymph node, where lymph node metastasis firstly occurs, attracts much attention in the surgical treatment of malignant tumors. Hence, sentinel lymph node biopsy (SLNB) came into being. Recent studies have indicated that SLNB is safe and feasible for early cervical cancer and SLNB is recommended to patients with early cervical cancer. This article will introduce the application of SLNB in cervical cancer in the recent years and discuss its clinical value and related challenges.

Objective To investigate the characteristics of human immunodeficiency virus(HIV-1)V3 loop amino acid mutations among AIDS patients in Shenzhen. Methods Fragments of HIV-1 env gene were amplified by RT-nested-polymerase chain reaction(PCR)from plasma of the AIDS patients in Shenzhen.The PCR products were then directly sequenced and the sequences were aligned,translated and analyzed. Results Sequence analysis showed that there were B and CRF01-AE HIV-1 subtypes in Shenzhen.The V3 loop terra peptide GPGQ accounted for about 48%,GPGR about 36%,other V3 loop terra peptide forms were 16%;the V3 loop central motif in the majority(76.9%)of the CRF01-AE strains was GPGQ,the majority(75%)of the B strains was GPGR.We also found some unusual terra peptide compositions:DQDR and DQGQ on the tip of V3 loop,some amino acid mutations at specific of V3 loop associated with SI phenotype were very common in AIDS patients(80%). Conclusions The V3 loop amino acid mutations were very common in AIDS patients,the V3 loop central motif in the majority was GPGQ and GPGR in Shenzhen,the mutations shows the change of HIV-1 phenotype and predicts that disease progress to AIDS.

Objective To study the angular characteristics of facial profile in normal Han Chinese adults of Guangdong natives and the value of measurement methods adapted in this project. Methods One hundred and fifty Han Chinese adults (ratio of male to female,1∶1)were randomly chosen and parameters for computer aided angular analysis of facial soft tissues included:lateral angles:∠Ns Prn Pgs;∠Ns Prn GsPgs;∠Ns Prn Sn; As Ns Bs;∠Ns Sn Pgs;∠Gs Ns Prn;∠Cm Sn Ls and ∠Li Bs Pgs. front angles: ∠Zyr Rc Mes; ∠Zyl Lc Mes; ∠Exr Exl Sn; ∠Exl Exr Sn; ∠Exr Sn Exl; ∠Enl Enr Sn; ∠Enr Enl Sn; ∠Enr Sn Enl; ∠Sn Chr Chl; ∠Sn Chl Chr and ∠Chr Sn Chl.Results Lateral angles ∠Ns Prn Sn and ∠Li Bs Pgs,in male were larger significantly than that those in female, but ∠Gs Ns Prn in male was smaller significantly than that in female. Front angles,∠Zyr Rc Mes and ∠Zyl Lc Mes,in male were larger significantly than those in female.Conclusion Angular analysis plays a unique role in the measurement of facial soft tissue profile. There is a difference of facial soft tissue profile between male and female Han Chinese.

OBJECTIVE: To establish a new pattern of ward round record for clinical pharmacist and rational use of drug. METHODS: The new pattern of ward round record was established according to domestic and foreign history pattern, The Principle and Proposed Pattern of Clinical Medication History in China, disease course record. This new pattern focused on patients’ disease and medication changes. A case of cardiovascular department was taken as example. RESULTS: Established ward around record contained two parts, i.e. first page and record chart. CONCLUSION: Established pattern is concise and practical and covers essential medical information. It makes communication more easily between pharmacist and doctors and meets the needs of clinical pharmacy practice.

Objective To explore the clinical value of lymphocyte sub-population and NK levels in patients with primary lung malignant tumor and patients with chronic obstructive pulmonary disease (COPD). Methods The percentage of CD3 +,CD4 +, CD8 +, CD19 + and NK cells were measured in 60 COPD patients and 50 primary lung malignant tumor patients and 40 normal control subjects using alkaline phosphatase antialkaline phosphatase (APAAP) assay, and CD4 +/CD8 + ratio was calculated. Results The levels of CD3 +,CD4 +,CD4 +/CD8 + and CD19 + cells were significantly lower in the patients with primary lung malignant tumor or COPD than those in the normal control subjects, which CD8 level was significantly higher (P0.05). No difference in the levels of CD3 +, CD4 + and CD8 + cells was found between the primary lung malignant tumor and COPD patients, but NK and CD19 + cells levels had significant difference(P

Objective: To study the relationship between maternal behavior and behavior problem of their children Method: 765 mothers with children aged 6 to 11 were assessed with MBQ (maternal behavior questionnaire) and behaviors of their children were assessed with CBCL (Achenbach children's behavior checklist) Results: 12 0% of children was identified as having behavior problems Maternal supportive behavior decreased behavior problems of their children, while maternal un-supportive behavior increased that Conclusion: Maternal behaviors had a significant effect on children's behavior problem

Objective To investigate the mechanism of hydrogen therapy for gouty arthritis,and provide new strategy for gout via a diet therapy by building up the crystal arthritis (gout) animal model.Methods Wistar rats (200±20) g were randomly divided into five groups which were consisted of five rats,including:the hydrogen-water model group,the hydrogen-feed model group,the hydrogen-water and hydrogenfeed model group,the control model group,and the blank group.And the first,the second,the third group collectively referred to as the hydrogen group.The rat model of acute gouty arthritis was established via injecting monosodium urate (MSU) in rats' ankles,after 14 days continuous feeding.On the third day after injection,serum samples were collected and analyzed.The swelling feet were removed and kept in the 40％ neutral formaldehyde for histochemicalstudies.During the three days after MSU injection,the volume of whole feet (including the ankle joint) was also recorded.The results were analyzed with one-way ANOVA and tamhane's T2 methods.Results In this study,a moderate elevated level of observed parameters,such as swelling joints numbers and inflammatory factor levels,was observed in the hydrogen feed model group than other groups.To measure the volume of rats' feet and found that the volume of feet of the control model group was 1.24 times (0.40±0.06,P＜0.05) as big as hydrogen group.And the TNF-α,IL-1,malondialdehyde in the serum of the hydrogen group were also less than those of the control model group.The contention of TNF-α of the control model group was 6.23 times (336±60,P＜0.05) as much as the hydrogen group.The contention of IL-1β of the control model group was 4.02 times (249±42,P＜0.05) as much as the hydrogen group.The contention of MDA of the control model group was 2.18 times (24±4,P＜0.05) as much as the hydrogen group.Conclusion The oral hydrogen intake has a definite therapeutic effect on controlling articular inflammation,which is helpful in exploring the dietary therapy for gouty arthritis.

The clinical and electrocardiographic data of 35 cases with CAVB were analyzed. They could be divided into two groups: chronic (28 cases) and transcient(7 cases). The primary diseases of the patients in the chronic group were coronary heart disease(CHD) in 11 cases, a condition of unknown cause in 12, and miscellaneous diseases in 5.The clinical and ECG manifestations of the 12 cases with unknown cause were suggestive that the disorder was most likely to be primary degeneration of conduction bundles(PDCB). PDCB differed from CHD by the following:(1) In PDCB, there was neither history of chest pain nor factors vulnerable to CHD being found. No ischemic changes cound be found on the ECG of PDCB cases.(2) The duration of CAVB was longer in PDCB cases (mostly over 3 years) than in CHD cases (all under 2 years).(3) The onset of CAVB occurred at a younger age in PDCB(an average of 50.6 years) than in CHD(an average of 66.3 years).The difference between the two was significant(P