1.Experimental Study on Pathological Changes and Their Mechanism in Rat Brain Tissue with Acute Cyanide Poisoning
Journal of Third Military Medical University 1988;0(05):-
Observations on the developement of pathological changes of rat brain, together with dynamic detection of CN- concentrations in blood and brain tissue and quantitive analysis of brain cytochrome oxidase activity, are carried out within 24 h after acute cyanide intoxication (4.5mg/kg i.p.) . The results indicate that in the cyanide poisoning with the dose under lethality (80%LD) , the pathological changes in rat brain appear, especially in cytochrome oxidase poorly- contained areas, including! 1 ) degeneration and necrosis of neurons and gliocytes; 2) degeneration, swelling and lysis of different cell projection components; 3) the myelinoclasis of myelinated nerve fibers. Those changes undergo a dynamic course divided into three phases: 1 ) the phase of metabolic disturbance; 2) of response to injury; and 3) of restoration. The authors consider that the acute poisoning displayed by the animal after NACN injection is directly caused by the intense inhibation of brain cytochrome oxidase; the secondary lesions of brain structure may be responsible for the manifestations such as trembling, unstable, and ataxia etc.occur later. The mechanisms of the brain pathological changes after cyanide intoxication are also disscussed.
2.The application of acetabular reinforcement ring in total hip arthroplasty and its preliminary results
Yisheng HAN ; Qingsheng ZHU ; Yaoping WU
Chinese Journal of Orthopaedics 1998;0(12):-
Objective To evaluate the effects of Burch-Schneider(BS) acetabular reinforcement ring applied in primary or revision total hip arthroplasties in 9 patients with combined or cavitary acetabular bone defects. Methods A retrospective follow up that averaged 3.8 years was performed with a special scoring system comprising the patients symptoms, signs and function. Results The excellent and good function were achieved in 89% of all cases. Conclusion 1)BS reinforcement ring could be effectively and reliably applied in primary or revision total hip arthroplasty or in patients with severe acetabular bone defects. 2)BS reinforcement ring shows the biological fixation feature, so as to provide good foundation for long-term satisfactory function of hip. 3)The lower ear of BS ring need not to be fixed to ischium with screws as usual, but be inserted in obturator foramen above transverse ligament, thus imparting some elastic resilience to it. 4)The upper ear should be folded through such a curve that its curvature was in compliance with that of ilium, which would be better performed in one session. 5)The appropriate amount of 0.8 cm?0.8 cm?0.8 cm morcellized allografting bone was used to snugly fill the space, which would be conducive to desirable incorporation between prosthesis and bone, and the authors propose that the patients should be allowed weight-bearing earlier.
3.Theory and Method of Analysis on Systematic Hypothesis for Adverse Drug Events
Hanyong ZHU ; Longjing WEI ; Yisheng REN
China Pharmacy 2001;0(11):-
OBJECTIVE: To establish the theory and method for the analysis of systematic hypothesis on adverse drugs events. METHODS: System of causal analysis of adverse drug events and analytical methods on systematic hypothesis were established by applying systematical and scientific thoughts; and the application of which in the quality analysis of oral solid preparations and injections were explained. RESULTS: The system of causal analysis consists of subsystems of drug standard deficits, problems of drugs quality, adverse drugs reactions, medication errors and drug abuse subsystems. The analysis on systematic hypothesis consisted of 4 steps: producing signal, raising the hypothesis, demonstrating, and drawing the conclusions. CONCLUSION: The causal analysis system of adverse drug events and analytical methods on systematic hypothesis combined not only reductionism with holism but also analysis with synthesis, which can help to solve the complicated matter in clinical medication.
4.Pharmaceutical Evaluation Factors of Clinical Drugs
Hanyong ZHU ; Longjing WEI ; Yisheng REN
China Pharmacy 2007;0(26):-
OBJECTIVE: To lay a basis on constructing theory and method of the pharmaceutical evaluation.METHODS: By synthesizing the literature and experience,the authors summarized and explained the pharmaceutical evaluation factors which included rationality of preparations,quality controllability,and delivery efficacy etc.RESULTS: The factors of rationality of preparations included the choice of dosage form,specification and package amount;the factors of quality controllability included active constituent,foreign matter,package and stability,and the factors of delivery efficacy included dissolution or releasing degree and device packaging,CONCLUSION: This system of evaluation factors is systematic,dynamic and practical.
5.Small renal cell carcinoma: CT and pathologic correlation
Tianzhao ZHU ; Yisheng WANG ; Tongli XIA
Chinese Journal of Radiology 1999;0(10):-
Objective To analyze the correlation of CT and pathological manifestation of small renal cell carcinoma (SRCC). Methods Thirty six SRCC were all diagnosed by surgical pathology. On CT, attenuation value and the amount of enhancement were observed; on pathology, tumor cell characteristics, cell arrangement, the stage and grade of the tumor et al were observed. Results 31 tumors were iso or hypoattenuation on CT and clear cell tumors were dominant in 28 cases; 5 cases were hyperattenuation and 2 of them were granular cell carcinoma. After the contrast enhancement, 31 tumors were enhanced more than 40 HU. 27 of them were solid which had abundant sinusoid vessels; Enhancement in 29 cases was heterogeneous, and on pathology, hemorrhage and necrosis were found in 27 of them. Conclusion The CT findings of SRCC were correlated with tumor cell characteristic and architecture.
6.Development of PET scanner for small animals
Ying LIU ; Qingli QIAO ; Qiushi REN ; Yisheng ZHU
Chinese Medical Equipment Journal 1993;0(06):-
In comparison with the clinical PET scanner,PET scanner for small animals puts forward a higher demand in spacial resolution and sensitivity. This article describes the development of the PET scanner for small animals and compares the characteristics of several kinds of contemporary typical PET scanners for small animals in different aspects based on the development of detectors. Meanwhile,it also introduces the development of the detectors designed for measuring depth of interaction (DTC) to reduce parallax error.
7.Recurrence plot analysis of HRV for brain ischemia and asphyxia.
Xiaoming CHEN ; Yihong QIU ; Yisheng ZHU
Journal of Biomedical Engineering 2008;25(1):39-43
Heart rate variability (HRV) is the tiny variability existing in the cycles of the heart beats, which reflects the corresponding balance between sympathetic and vagus nerves. Since the nonlinear characteristic of HRV is confirmed, the Recurrence Plot method, a nonlinear dynamic analysis method based on the complexity, could be used to analyze HRV. The results showed the recurrence plot structures and some quantitative indices (L-Mean, L-Entr) during asphyxia insult vary significantly as compared to those in normal conditions, which offer a new method to monitor brain asphyxia injury.
Algorithms
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Animals
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Autonomic Nervous System
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physiopathology
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Electrocardiography
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methods
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Heart Rate
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physiology
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Hypoxia-Ischemia, Brain
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physiopathology
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Male
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Nonlinear Dynamics
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Rats
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Rats, Wistar
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Signal Processing, Computer-Assisted
8.Effect of calcium cyanamid synthetic drug on Schistosoma japonicum egg morphology
Yisheng ZHOU ; Guohua PENG ; Zhuhua HU ; Xiaowu FENG ; Rong ZHU ; Wangyuan WEI ; Jiagang GUO
Chinese Journal of Schistosomiasis Control 2015;(1):56-58
Objective To study the morphological change of Schistosoma japonicum eggs processed by calcium cyanamide synthetic drug,so as to provide the basis for further study of the mechanism that calcium cyanamide synthetic drug to schisto?some eggs. Methods The calcium cyanamide synthetic drug was added to the cattle feces containing schistosome eggs and mixed up,and then the cattle feces was stacked as original shape on the marshland. Blank controls were set at the same time. The cattle feces samples were collected and the schistosome eggs were observed under a microscope on the 1st,2nd,3rd,7th day after the experiment. Results By the effect of calcium cyanamide synthetic drug,the color of eggs was deepening gradual?ly,the miracidia were atrophied,and the shells of eggs were thickened. The embryonic membrane of miracidia was no longer completed 3 days later,and the miracidia were deformed severely 7 days later. The atrophy of miracidia was not obvious in the blank controls. Conclusion The schistosome miracidia and embryonic membrane can be damaged by the calcium cyanamide synthetic drug,and worse damaged with time extending.
9.Serious complications of transurethral resection of the prostate
Heqian LIU ; Yisheng CHEN ; Bin ZOU ; Jian KONG ; Lingsong TAO ; Guangbiao ZHU
Chinese Journal of Urology 2016;37(7):515-518
Objective To analyze the serious complications of transurethral resection of the prostate (TURP).Methods A retrospective study was conducted to summarize the clinical data of 1950 patients with benign prostatic hyperplasia from January 2005 to December 2014.All patients received TURP.The mean patient Age,disease course,IPSS score,PV and Qmax of 1 950 eligible patients were 71 years (54 to 87 years),7.6 years(0.5 to 15.0 years),(65.1 ±33.4)ml,25.5 ±3.9 and (8.1 ±2.6)ml/s,respectively.Intraoperative and postoperative complications were graded according to the CLASSIC and modified Clavien classifications,respectively.Serious complications were defined as grade Ⅲ or higher.Results Among the TURP procedures,99 serious complications occurred,resulting in a serious complication rate of 5.1%,Serious intraoperative and postoperative complication rates were 1.2% (24 cases) and 3.9% (75 cases),respectively.Serious intraoperative complications included ureteral orifice injury (3 cases),bladder explosion (4 cases),and transurethral resection syndrome (17 cases).Serious postoperative complications included massive hemorrhage (26 cases),severe dysuria (18 cases),permanent urinary incontinence (4 cases),cardio-cerebral vascular accident (5 cases),pulmonary thrombosis (3 cases),severe infection(18 cases),and death (1 case).Conclusions Serious complications may occur at any stages during TURP.Understanding the causes and characteristics of complications,strengthening the prevention and effective treatment is the key measure to reduce the incidence rates.
10.Retroperitoneal laparoscopic nephrectomy for nonfunctioning kidney
Jiawei WANG ; Yisheng CHEN ; Yousheng YAO ; Jian HUANG ; Guangbiao ZHU ; Lingsong TAO ; Lei XU
Chinese Journal of Postgraduates of Medicine 2014;37(29):26-28
Objective To investigate the clinical application value of retroperitoneal laparoscopic nephrectomy for nonfunctioning kidney.Methods Fifty-four cases of retroperitoneal laparoscopic nephrectomy for nonfunctioning kidney were reviewed,including 9 cases with nonfunctioning tuberculosis pyonephrosis,18 cases with infection nonfunctioning pyonephrosis and 27 cases of nonfunctioning hydronephrosis.Fifty-four cases were received retroperitoneal laparoscopic nephrectomy,tuberculous and infection pyonephrosis underwent laparoscopic resection surrounding adipose capsule,nonfunctioning hydronephrosis underwent laparoscopic resection by pumping water to increase the peritoneal space.Results The operation of 54 cases were perfomed successfully.None of the patient required conversion to open surgery.During the surgery,1 case showed mild extravasation of cheese-like pus induced by laceration of the kidney capsule;2 cases had injuried on the peritoneum.The mean operation time was 125 (95-230) min,the mean blood loss was 84 (50-420) ml.All patients showed primary healing of the wound,the patients were discharged from the hospital in 6 to 11 d (mean 7.5 d).After followed up for 5-27 months,none of them had long-term complication.Conclusions Retroperitoneal laparscopic nephrectomy for nonfunctioning kidney has advantages of minimal invasion,less blood loss and quicker recovery,so it is a fairly safe and effective procedure for nonfunctioning kidney.