Objective To investigate the effect of passive exercise on neural functional recovery after peripheral nerve crushed injury.MethodsThe effect of passive exercise on early peripheral nerve regeneration and recovery of motor function were observed with electrophysiological and histological indexes compared with that of the splinting group.ResultsThe nerve conduction of training group was faster than that in the splinting group,and the latency of compound muscle action potentials(CMAP)was shorter(P<0.05).The thickness of myelin sheath,average numbers of myelinated nerve fibera per area and diameter of regenerating axon in training group were larger than those in the splinting group(P<0.05).The wet weight of sural triceps of training group were bigger than that of the splinting group(P<0.01).ConclusionThe passive exercise can improve the early recovery of motor function and neural regeneration after peripheral nerve crushed injury.

Objective To explore the diagnoses of spontaneous intracranial hypotension,and discuss the therapeutic efficacy of epidural blood patch therapy in spontaneous intracranial hypotension patients.Methods The clinical data of 12 patients with spontaneous intracranial hypotension,admitted to our hospital from January 2013 to December 2018,were retrospectively analyzed.The lumbar puncture results,MR imaging features of the skull and spine,and CT myelography (CTM) features of these patients were analyzed.The treatment efficacies of epidural blood patch,which included blind epidural blood patch and targeted epidural blood patch,were compared.Results The cerebrospinal fluid pressure of 12 patients was ≤ 60 mmH2O.Ten patients (83.3％) showed subdural fluid collections,enhancement of the pachymeninges,engorgement of venous structures,pituitary hyperemia,and sagging of the brain on brain MR imaging,and one of the patient showed pituitary hemorrhage.Seven patients (63.3％) showed spinal dural epithelial fluid accumulation and venous plexus expansion on spine MR imaging,and one of the patient showed dorsolateral dural discontinuous thickening of T6 and forward movement of the spinal cord caused by massive dorsal epidural effusion.Twelve patients in this group underwent CTM,and were found cerebrospinal fluid leakage.Twelve patients applied 14-times epidural blood tests;4 responded well to one-time targeted epidural blood patch therapy,with success rate of 100％;8 patients used blind epidural blood patch therapy,and 6 patients responded well to one-time therapy,with success rate of 75％,one patient improved with blind epidural blood stick twice,and one patient was ineffective twice.Conclusions Head MR imaging combined with spinal MR imaging is a non-invasive method to diagnose spontaneous intracranial hypotension.Myelogram can determine whether there is a leakage of spinal cerebrospinal fluid and accurately locate the leakage site.Epidural blood patch therapy is an effective method for treatment of patients with spontaneous intracranial hypotension.With the precise location of leak points by myelography,targeted epidural blood patch is more effective.

A case of suppurative meningitis caused by Streptococcus suis infection is reported. The patient was an elderly female with an atypical epidemiological history. The common symptoms included fever, headache and cervicodynia. According to the results of blood bacterial culture and next-generation sequencing of cerebrospinal fluid, the patient was considered purulent meningitis caused by Streptococcus suis. After treatment with the third generation cephalosporins, the symptoms improved significantly. One week after the onset of the disease, herpes labialis occurred, followed by hearing loss about 1 week later. The patient was treated with antiviral and hormone therapy, and was discharged after improvement.

Purpose: Circular RNAs (circRNAs) are a new class of RNA molecules whose function is largely unknown. There is a growing evidence that circRNAs play an important regulatory role in the progression of a variety of human cancers. However, the exact roles and the mechanisms of circRNAs in gastric cancer are not clear. In this study, we aimed to elucidate the mechanism of hsa_circ_0005556. Materials and Methods: Real-time quantitative polymerase chain reaction was used to detect the expression of hsa_circ_0005556, miR-4270, and matrix metalloproteinase-19 (MMP19) in gastric cancer tissues and cell lines. The expression of hsa_circ_0005556 in gastric cancer cells was silenced by lentivirus, and cell proliferation, invasion, migration, and tumorigenesis in nude mice were assessed to evaluate the function of hsa_circ_0005556 in gastric cancer. Results: The expression of hsa_circ_0005556 in gastric cancer tissues and gastric cancer cell lines was higher compared to normal controls. In vitro, the downregulation of hsa_ circ_0005556 significantly inhibited proliferation, migration, and invasion of gastric cancer cells. In vivo, the downregulation of hsa_circ_0005556 suppressed tumor growth in nude mice. Conclusions Our study shows that the hsa_circ_0005556/miR-4270/MMP19 axis is involved in proliferation, migration, and invasion of gastric cancer cells through the competing endogenous RNA (ceRNA) mechanism.

Objective: To observe the effect of cancer nursing plan based on risk concept on complications, self-care ability and quality of life of patients with cervical cancer undergoing radiotherapy. Methods: Totally 68 patients with cervical cancer undergoing radiotherapy from February 2016 to February 2018 were included in the study. According to the random method of drawing lots, they were divided into two groups, 34 cases each. The control group was given routine nursing intervention, while the observation group was given cancer nursing plan based on risk concept. The intervention time was from the day of admission to the end of discharge. Comparing the incidence of complications between the two groups, the self-care ability implementation scale and the Chinese version of the World Health Organization quality of life scale were used to evaluate the self-care ability and quality of life before and after the intervention. Results: The incidence of complications was 14.70% (5/34) in the observation group and 38.23% (13/34) in the control group, with statistically significant difference (t=4.836, P<0.05).Before intervention, there was no significant difference in scores of each sub-item and total score of self-care ability implementation scale between the two groups (t=0.336-1.224, P>0.05). After intervention, the health knowledge level, self-concept, self-responsibility, self-care skills and total score of the observation group were (48.37±4.10), (27.56±4.12), (26.56±5.09), (29.54±5.87), (132.02±19.15) points, respectively. After intervention, the scores of the above dimensions and the total scale in the control group were (44.10±3.74), (24.16±3.47), (20.40±4.12), (24.13±3.65) and (112.78±14.97) points, respectively, with statistically significant differences (t=3.680-5.485, P<0.05). Before intervention, there was no significant difference in sub-item scores and total scores of QOL between the two groups (t=0.151-0.996, P>0.05); After the intervention, the observation group physiological, psychological, social relations, the environment and total score of (24.85±2.63), (21.34±2.73), (20.76±2.47), (19.07±2.45), (86.02±10.27) points and the control group was (19.09±2.03) points, (17.65±2.13), (17.29±2.30), (16.38±2.37), (70.41±8.82) points, the difference had statistical significance (t=4.601-10.109, P<0.05). Conclusion Tumor care plan based on risk concept can reduce the incidence of complications related to radiotherapy for cervical cancer patients, and improve their self-care ability and quality of life.