1.Study on effect of celecoxib on CNE-2Z cell lines in human nasopharyngeal carcinoma
Journal of Chongqing Medical University 2007;0(11):-
Objective:To study the growth inhibition and potential mechanisms of celecoxib on nasopharyngeal carcinoma CNE-2Z cell lines.Methods:The effect of celecoxib on the growth of CNE-2Z cells was evaluated by MTT assay.The expressions of proliferating cell nuclear antigen(PCNA)and cyclooxygenase-2(COX-2)were assessed by immunocytochemistry method.Cell cycle was measured by Flow cytometry(FCM).Results:Celecoxib inhibited the proliferation of CNE-2Z cells in dosage and time dependent manner.The cell cycle was arrested in G0/G1 phase in CNE-2Z cells treated with celecoxib;Immunocytochemistry showed that the expressions of PCNA and C0X-2 decreased after incubated with celecoxib for 48 hours.Conclusion:The expression of COX-2 is found in CNE-2Z cell lines.The growth of CNE-2Z cell 1ines can be inhibited by celecoxib.Celecoxib may be used as chemotherapeutic agent for nasopharyngeal carcinoma.
2.Clinical analysis on 14 cases with malignant melanoma in nasal cavity and sinus.
Yinzhou XIANG ; Ping PENG ; Lianzhi WEI
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;23(17):784-786
OBJECTIVE:
To investigate the effect of treatment on malignant melanoma in nasal cavity and paranasal sinus.
METHOD:
Fourteen patients with malignant melanoma in nasal cavity and paranasal sinus were retrospectively analyzed from 1995 to 2002, including clinical presentation, diagnosis, treatment and follow-up data.
RESULT:
Thirteen patients were followed up, the survival rates of 3 and 5 years were 42.9% and 21.4% respectively.
CONCLUSION
Sinonasal malignant melanoma has an aggressive behavior and easy recurrence. Early diagnosis, radical operation and postoperative radiotherapy could improve the survival rate.
Adolescent
;
Adult
;
Aged
;
Female
;
Humans
;
Male
;
Melanoma
;
mortality
;
Middle Aged
;
Nasal Cavity
;
Nose Neoplasms
;
mortality
;
Paranasal Sinus Neoplasms
;
mortality
;
Retrospective Studies
;
Survival Rate
;
Young Adult
3.Comparing between CAUP and UPPP in treatment of OSAHS.
Zhijie XIONG ; Songqin ZHANG ; Ping PENG ; Yinzhou XIANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2008;22(24):1123-1124
OBJECTIVE:
To evaluate the prospective effect of CAUP and applying midline partial glossectomy with UPPP in the treatment of OSAHS.
METHOD:
One hundred OSAHS patients were distributed into two groups averagely. The patients of the two groups had CAUP and midline partial glossectomy respectively. All patients were followed-up 6 months and 12 months after operation and carried out using PSG every time.
RESULT:
Therapeutic effect was evaluated by standard of Hangzhou (2002). In general, in 6 months, curative effect was excellent in 41 patients of the group of CAUP, good in 8 patients with effect, bed effect in 1 patients; in 12 months, it was excellent in 28 patients, good in 13 patients, bed in 9 patients. In 6 months, the curative effect the other group were excellent in 44 patients, good in 5 patients, bed in 1 patients; In 12 months, it was excellent in 43 patients , good in 6 patients, bed in 1 patients. In 6 month, the results showed that the effect of the two methods was similar (P > 0.05), but in 12 months the effect of group of CAUP was better than the other obviously (P < 0.01).
CONCLUSION
This operation could enlarge the narrow area of palatopharyngeal cavity effectively and decrease postoperative complications. It's a safe effective and acceptable surgical procedure.
Adult
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Aged
;
Catheter Ablation
;
methods
;
Female
;
Humans
;
Male
;
Middle Aged
;
Otorhinolaryngologic Surgical Procedures
;
methods
;
Palate
;
surgery
;
Pharynx
;
surgery
;
Sleep Apnea, Obstructive
;
surgery
;
Tongue
;
surgery
;
Treatment Outcome
;
Uvula
;
surgery
4.Epidemiological study on the incidence of rheumatoid arthritis in adults in Yinzhou district, Ningbo city from 2011-2020.
Xue Yang ZENG ; Zhi Ke LIU ; Peng SHEN ; Ye Xiang SUN ; Xiang LIU ; Si Yan ZHAN ; Hong Bo LIN ; Feng SUN
Chinese Journal of Epidemiology 2022;43(8):1288-1295
Objective: To describe the distribution and trend of rheumatoid arthritis (RA) in adults in the Yinzhou district from 2011 to 2020 and compare the incidence differences in different ages and genders. Methods: Using the retrospective cohort design, we collected all new cases diagnosed with RA between 2011 to 2020 from the Yinzhou Regional Health Information Platform (YRHIP). Poisson distribution was used to estimate RA's incidence density and 95%CI. Results: From 2011 to 2020, 1 280 012 permanent residents in Yinzhou district were included, of which 665 361 were female (51.98%). The total follow-up person-years were 7 198 513.61, and the median follow-up person-year was 5.41 years (P25=3.50, P75=8.32). During the study period, there were 2 350 new cases of RA, of which 1 460 were female (62.13%). The 10-year incidence density of the population was 32.65/100 000 person-years (95%CI: 31.34/100 000 person-years-33.99/100 000 person-years), that of females was 39.17/100 000 person-years (95%CI: 37.19/100 000 person-years-41.24/100 000 person-years), and that of the male was 25.64/100 000 person-years (95%CI: 23.98/100 000 person-years-27.38/100 000 person-years), the gender difference was statistically significant (P<0.001). The incidence risk in all age groups above 30 years old was higher than that in the 18-29 years old group (P<0.001), and the incidence risk increased with age from 18-79 years old while decreased slightly with age ≥80 years old. The lowest incidence density was 15.30/100 000 person-years in 2013 (95%CI:12.62/100 000 person-years-18.38/100 000 person- years), and the highest was 56.70/100 000 person-years in 2016 (95%CI: 51.24/100 000 person- years - 62.58/100 000 person-years), with statistically significant differences among different years (P=0.004). Conclusions: From 2011 to 2020, the incidence density of RA in adults in Yinzhou district first increased, then decreased, and tended to stabilize. There were differences in incidence density in different years, ages, and genders.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Arthritis, Rheumatoid/epidemiology*
;
Cohort Studies
;
Female
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Retrospective Studies
;
Sex Factors
;
Young Adult
5.Fingertip replantation with anastomosis of palm vein and retaining the nail.
Xiang WANG ; Wei-Kai ZHANG ; Shao-Meng YIN ; Hai-Bing WANG ; Tao HE ; Yong-Qing GONG ; Guo-Ming ZHU ; Gen-Lian MAO ; Ming-Xing HU ; Jian LI
China Journal of Orthopaedics and Traumatology 2013;26(8):639-641
OBJECTIVETo study the replantation methods and clinical results of amputated fingertip.
METHODSFrom October 2007 to June 2011, 18 fingers of 13 cases were replanted with anastomosis of palm vein and retaining the nail, including 9 males and 4 females,with an average age of 26 years old ranging from 17 to 45 years old. The time from injury to therapy was from 30 min to 5 h, time of broken finger ischemia was from 1.5 to 7 h. All broken fingers were preservation under normal temperature.
RESULTSAll fingers were survived, no vascular crisis happened. All cases were followed up from 3 to 24 months with an average of 14 months. The length and shape of replanted fingers were similar to that of the healthy side. The new nails were smooth, the function was perfect,the sense of pain and touched sensation had been recovered. Their two-piont discriminations ranged from 3 to 6 mm with an average of 5 mm. According to the assessment standard of Chinese Medical Association of Hand Surgery, the results were excellent in 14 cases, good in 3 cases, poor in 1 case.
CONCLUSIONFingertip replantation with anastomosis of palm vein and retaining the nail is regained satisfactory appearance and function of the digits with a high survival rate.
Adolescent ; Adult ; Anastomosis, Surgical ; methods ; Female ; Fingers ; surgery ; Hand ; blood supply ; Humans ; Male ; Middle Aged ; Nails ; surgery ; Replantation ; methods ; Veins ; surgery ; Young Adult
6.Epidemiological study on the incidence of inflammatory bowel disease in Yinzhou District, Ningbo City from 2011 to 2020.
Bing Jie HE ; Zhi Ke LIU ; Peng SHEN ; Ye Xiang SUN ; Bin CHEN ; Si Yan ZHAN ; Hong Bo LIN
Journal of Peking University(Health Sciences) 2022;54(3):511-519
OBJECTIVE:
To describe the distribution characteristics of inflammatory bowel disease among permanent residents in Yinzhou District, Ningbo City, and to understand the disease burden and development trend of inflammatory bowel disease in this area.
METHODS:
Using the retrospective cohort design, we collected the registration information of all permanent residents in the residents' health files of the Yinzhou Regional Health Information Platform from 2010 to 2020, and used electronic medical records to follow up their inflammatory bowel disease visits. A one-year wash-out period was set, and the patients who were diagnosed with the primary diagnosis for the first time after one year of registration were re-garded as new cases. The incidence density and 95% confidence interval (CI) of inflammatory bowel disease were estimated by Poisson distribution.
RESULTS:
From 2011 to 2020, a total of 1 496 427 permanent residents in Yinzhou District were included, of which 729 996 were male (48.78%). The total follow-up person-years were 8 081 030.82, and the median follow-up person-years were 5.41 [interquartile range (IQR): 5.29]. During the study period, there were 1 217 new cases of inflammatory bowel disease, of which males (624 cases, 51.27%) were more than females (593 cases, 48.73%). The total incidence density was 15.06/100 000 person-years (95%CI: 14.23, 15.93). Among all new cases, there were 1 106 cases (90.88%) of ulcerative colitis, with an incidence density of 13.69 per 100 000 person-years (95%CI: 12.89, 14.52); 70 cases (5.75%) of Crohn's disease, with an incidence density of 0.87 per 100 000 person-years (95%CI: 0.68, 1.09); and 41 cases (3.37%) of indeterminate colitis, with an incidence density of 0.51 per 100 000 person-years (95%CI: 0.36, 0.69). The median age of onset of ulcerative colitis was 50.82 years old (IQR: 18.77), with the highest proportion (15.01%) in the 45-49 years group. The incidence density of ulcerative colitis gradually increased with age, reaching a relatively high level in the 45-49 years group (20.53/100 000 person-years; 95%CI: 17.63, 23.78), followed by a slight increase. And the incidence density in the 65-69 years group was the highest (25.44/100 000 person-years; 95%CI: 20.85, 30.75), with a rapid decrease in the 75-79 years group. The median age of onset of Crohn's disease was 44.34 years (IQR: 33.41), with the highest proportion (12.86%) in the 25-29 years group. Due to the small number of new cases of Crohn's disease, the age distribution fluctuated greatly, with peaks both in young and old people. From 2011 to 2020, the incidence density of inflammatory bowel disease in Yinzhou District was at a low level from 2011 to 2013, and showed a rapid upward trend from 2014 to 2016, reaching a peak of 24.62 per 100 000 person-years in 2016 (95%CI: 21.31, 28.30), and slightly decreased in 2017-2020.
CONCLUSION
The incidence density of inflammatory bowel disease in Yinzhou District from 2011 to 2020 was at a relatively high level, and medical institutions and health departments need to pay attention to the burden of disease caused by it.
Adolescent
;
Adult
;
Chronic Disease
;
Colitis, Ulcerative/epidemiology*
;
Crohn Disease/epidemiology*
;
Female
;
Humans
;
Incidence
;
Inflammatory Bowel Diseases/epidemiology*
;
Male
;
Middle Aged
;
Retrospective Studies
7.Rates and influencing factors of hospitalization after diagnosis among HIV infection cases in Yinzhou district of Ningbo, 2012-2020.
Zi Hui LI ; Qi ZHAO ; De Guang GONG ; Ye Xiang SUN ; Peng SHEN ; Hong Bo LIN ; Na HE
Chinese Journal of Epidemiology 2022;43(4):541-547
Objective: To understand the hospitalization rates and influencing factors after diagnosis among HIV infection cases, based on real-world data in Yinzhou district of Ningbo. Methods: A retrospective cohort study was conducted based on the databases of National AIDS Comprehensive Response Information Management System and Yinzhou Health Information Platform. The information about the following-up results, antiviral treatment data, electronic records of inpatient of the HIV cases reported during 2012-2020 were collected to analyze the rates, causes and influencing factors of hospitalization. Results: Among the 763 HIV infection cases reported in Yinzhou from 2012 to 2020, the hospitalization rate was 6.95% (53/763), and the number of inpatient was 2.59 per 100 person years. The hospitalization rate and the number of hospitalization per 100 person years in HIV infection cases were 3.16% (10/316) and 0.81 in those aged <30 years, 6.07% (15/247) and 1.59 in those aged >30 years, 7.86% (11/140) and 4.05 in those aged >45 years and 28.33% (17/60) and 17.40 in those aged ≥60 years respectively. Logistic multivariate regression analysis indicated that being aged ≥60 years was the influencing factor for hospitalizations in HIV infection cases (аOR=14.44, 95%CI:3.57-58.46). The hospitalization rates due to AIDS related diseases, cardiovascular diseases and metabolic diseases, and other diseases were 1.83% (14/763), 1.05% (8/763), and 3.93% (30/763), respectively. Conclusions: The hospitalization burden due to HIV infection was still mainly caused by those aged ≥60 years in Yinzhou, similar to that in general population and less proportion of hospitalizations were due to AIDS related diseases. The overall increase of hospitalizations due to AIDS was not obvious in Yinzhou.
Acquired Immunodeficiency Syndrome/epidemiology*
;
HIV Infections/therapy*
;
Hospitalization
;
Humans
;
Retrospective Studies
8.Accuracy of the China-PAR and WHO risk models in predicting the ten-year risks of cardiovascular disease in the Chinese population.
Wei Ye CHEN ; Xiao Fei LIU ; Peng SHEN ; Qi CHEN ; Ye Xiang SUN ; Jin Guo WU ; Ping LU ; Jing Yi ZHANG ; Hong Bo LIN ; Xun TANG ; Pei GAO
Chinese Journal of Epidemiology 2022;43(8):1275-1281
Objective: To externally validate and compare the accuracy of the China-PAR (Prediction for ASCVD Risk in China) model and the 2019 World Health Organization (WHO) cardiovascular disease risk charts for East Asian in predicting a 10-year cardiovascular disease in a general Chinese population. Methods: Participants aged 40-79 years without prior cardiovascular disease at baseline in the CHinese Electronic health Records Research in Yinzhou (CHERRY) were analyzed. The Kaplan-Meier analysis estimated the observed cardiovascular events (including non-fatal myocardial infarction, fatal coronary heart disease, and non-fatal or fatal stroke) rate within ten years. The expected risks were calculated using the WHO risk charts for East Asia (including the laboratory-based and non-laboratory-based models) and the China-PAR model. The expected-observed ratios were calculated to evaluate the overestimation or underestimation of the models in the cohort. Model accuracy was assessed by discrimination C-index, calibration χ2 value, and calibration plots. Results: During a median of 7.26 years of follow-up, 13 301 cardiovascular events were identified among 225 811 participants. The C-index for the China-PAR model, WHO laboratory-based model and WHO non-laboratory-based model were 0.741 (0.735-0.747), 0.747 (0.740-0.753), and 0.739 (0.733-0.746) for men, and 0.782 (0.776-0.788), 0.789 (0.783-0.795), and 0.782 (0.776-0.787) for women, respectively. The WHO laboratory-based model and non-laboratory-based model underestimated the 10-year ASCVD risk by around 15% in women and underestimated by 0.8% and 4.4% in men, respectively. The China-PAR model underestimated the risks by 19.5% and 42.3% for men and women. Conclusions: The China-PAR and WHO models all have pretty good discriminations for 10-year cardiovascular risk assessment in this general Chinese population. However, the accuracy should be improved in the highest-risk groups, suggesting further specific models are still needed for those with the highest risk, such as patients with diabetes or older persons.
Adult
;
Aged
;
Cardiovascular Diseases/epidemiology*
;
China/epidemiology*
;
Female
;
Humans
;
Male
;
Middle Aged
;
Risk Assessment
;
Risk Factors
;
World Health Organization
9.Epidemiological study of incidence of systematic lupus erythematosus in Yinzhou, Ningbo, 2016-2021.
Xue Feng LAI ; Zhi Ke LIU ; Peng SHEN ; Ye Xiang SUN ; Huai Chu LU ; Si Yan ZHAN ; Hong Bo LIN
Chinese Journal of Epidemiology 2023;44(7):1080-1085
Objective: To characterize the incidence density of systematic lupus erythematosus (SLE) in Yinzhou District of Ningbo from 2016 to 2021, and compare the age and gender specific differences. Methods: A retrospective cohort study was conducted based on the related data from 2015 to 2021 collected from the Health Information Platform of Yinzhou. Suspected SLE cases in local residents were identified by fuzzy matching of International Classification of Diseases 10th edition code "M32" or Chinese text "lupus". The classification criteria from Systemic Lupus International Collaboration Clinics-2012 and The European League Against Rheumatism/American College of Rheumatology-2019 were used for case verification. SLE cases were identified with specific algorithm based on verification results, and new cases were identified with 1 year as the washout period. The incidence density and 95%CI were estimated by Poisson distribution. Results: From 2016 to 2021, a total of 1 551 921 permanent residents were registered in Yinzhou, in whom 51.52% were women. The M(Q1,Q3) age at enrollment was 40.38 (27.54, 53.54) years. The M(Q1,Q3) of follow-up person-years was 3.83 (0.41, 5.83) years. There were 451 new SLE cases, in which 352 were women (78.05%). The 6-year incidence density was 8.14/100 000 person-years (95%CI: 7.41/100 000 person-years-8.93/100 000 person-years) for the total population, 3.68/100 000 person-years (95%CI: 2.99/100 000 person-years-4.48/100 000 person-years) for men and 12.37/100 000 person-years (95%CI: 11.11/100 000 person-years- 13.73/100 000 person-years) for women. The incidence density in men appeared a small peak at 20-29 years old, and began to increase with age from 40 years old. The incidence density in women was highest in age group 20-29 years (16.57/100 000 person-years) and remained to be high until 30-79 years old. The incidence density of SLE in Yinzhou show no significant temporal trend from 2016 to 2021 (men: P=0.848; women: P=1.000). Conclusions: The incidence density of SLE in Yinzhou from 2016 to 2021 was similar to those of other areas in China. SLE has a high incidence in women, especially in the young and elderly, suggesting that more attention should be paid to the diagnosis and treatment of SLE in women.
Adult
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Aged
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Female
;
Humans
;
Male
;
Middle Aged
;
Young Adult
;
Asian People
;
Incidence
;
Lupus Erythematosus, Systemic/diagnosis*
;
Retrospective Studies
;
China/epidemiology*
10.Clinical analysis on 18 cases of adenoid cystic carcinoma of nasal cavity and sinuses.
Yinzhou XIANG ; Lin YU ; Lianzhi WEI ; Ping PENG ; Ping GUI
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(20):1143-1145
OBJECTIVE:
To explore the clinical characteristics and treatment effect of adenoid cystic carcinoma in nasal cavity and sinuses.
METHOD:
Sixteen of all 18 cases of adenoid cystic carcinoma of nasal cavity and sinuses were performed operation and radiotherapy. Other 2 cases were performed radiotherapy.
RESULT:
Eighteen cases of patients were followed up for 5 years. Eight patients with early stage had no death. Five in 10 cases of advanced patients died, one case was out of following-up. In 11 of high differentiation group, 1 case died. In 7 of lower differentiation group, 4 cases died, 1 case lost.
CONCLUSION
Adenoid cystic carcinomas of nasal cavity and sinuses are distinct clinicopathological category and the clinical symptoms are noncharacteristic. Paying attention to the differential diagnosis and promoting related knowledge can help to avoid misdiagnosis. The prognosis is related to pathological category and clinical stage. High stage and high invasion of adenoid cystic carcinoma lead to poor prognosis.
Adult
;
Aged
;
Carcinoma, Adenoid Cystic
;
pathology
;
therapy
;
Female
;
Humans
;
Male
;
Middle Aged
;
Nasal Cavity
;
pathology
;
Nose Neoplasms
;
pathology
;
therapy
;
Paranasal Sinuses
;
pathology