1. HER2 status in gastric adenocarcinoma of Chinese: a multicenter study of 40 842 patients
Dan HUANG ; Zengshan LI ; Xiangshan FAN ; Hongmei WU ; Jianping LIU ; Wenyong SUN ; Shanshan LI ; Yinyong HOU ; Xiu NIE ; Jun LI ; Rong QIN ; Lingchuan GUO ; Jinghong XU ; Huizhong ZHANG ; Miaomiao SUN ; Qiaonan GUO ; Yinghong YANG ; Yanhui LIU ; Yu QIN ; Lijuan ZHANG ; Jinghe LI ; Zhihong ZHANG ; Peng GAO ; Yujun LI ; Weiqi SHENG
Chinese Journal of Pathology 2018;47(11):822-826
Objective:
To investigation HER2 status in gastric adenocarcinoma of Chinese and contributing factors to the HER2 expression.
Methods:
HER2 status of 40 842 gastric adenocarcinomas and clinical data were retrospectively collected from 23 hospitals dated from 2013 to 2016. The association between HER2 positivity and clinicopathologic features was analyzed.
Results:
Of the 40 842 patients the median age was 62 years, the male female ratio was 2.6∶1.0. The rate of HER2 positivity was 8.8% (3 577/40 842). HER2 expression was related to the tissue type, tumor location, Lauren classification and tumor differentiation (
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