Liver regeneration plays a crucial role in the recovery after liver injury induced by N-acetyl-p-aminophenol （APAP）. After APAP overdose， the degree of regeneration increases with the extent of liver injury， leading to the resolution of liver injury and spontaneous recovery in most cases. However， severe APAP overdose can impair liver regeneration and result in uncontrolled liver injury， even failure to recover or death in severe cases. Following APAP-induced liver injury， interactions between cells in the liver are essential for regenerative response. Liver regeneration is jointly regulated by multiple proliferative signaling pathways， involving various kinases， nuclear receptors， transcription factors， and coactivators. Severe APAP overdose can inhibit the activation of proliferative signaling pathways， thereby causing cell cycle arrest and impairing liver regeneration. Although liver regeneration plays a critical role in the repair of APAP-induced liver injury， the underlying mechanisms remain unclear. This article reviews the research advances in the role of liver regeneration in APAP-induced liver injury， in order to provide a reference for further basic research in this area.