Objective To explore the association of apoB gene polymorphisms with dyslipidemia and lipid levels in Xinjiang Shihezi Han Chinese. Methods 150 dyslipidemia patients and 150 normal pople were involved in this study. EcoRI and XbaI polymorphisms of apolipoprotein B was analyzed by PCR-restriction fragment length polymorphism. The levels of plasma total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, apoAI and apoB were determined. Results The frequency of E + E -/E - E - genotype and E-Allele(37.3% and 19% ) in dyslipidemia group was significantly higher than that in controls( 12. 7% and 6. 3% ). The levels of TC, TG and LDL-C in the E +E -/E - E - gene type were significantly higher than those of the E + E + gene type in each group ( P ＜0. 01 ). The frequency of X + X -/X + X + genotype and X + Allele( 20. 7% and 1 1% ) in dyslipidemia group was significantly higher than that in controls (8% and 4% ). The levels ofTC, TG, LDL-C and apoB in the X + X -/X + X + gene type patients were significantly higher than those in the X - X - gene type patients in every group ( P ＜ 0. 05 ). Conclusion The EcoRI and XbaI polymorphism of ApoB gene was related to dyslipidemia in population of Xinjiang Shihezi Han Chinese, and the E - and X + Allele may be the genetic risk factors for dyslipidemia.

Objective:To evaluate the hemostatic efficacy of N-carboxyethylchitosan fiber gauze (numbered NWL-K) in a leporine bleeding wounds of intraperitoneal parenchymal visceral.Methods:Sixty New Zealand rabbits were divided into two groups according to the randomized digital number method, with 30 rabbits per group. The leporine bleeding models of hepatic or splenic wound were made respectively. The two groups were subdivided into three groups: common gauze group, SURGICEL group and NWL-K group, with 10 rabbits per group. By analyzing the weight of excised liver tissue and amount of bleeding, the model stability was measured. The time to hemostasis and bleeding score in each group were analyzed every (20±5)seconds after compression for 30 seconds in the hepatic bleeding models or every (30±5)seconds after compression for 3 minutes in the splenic bleeding models. The adhesion between wound and gauze was evaluated at the same time.Results:There was no significant difference in the weight of excised liver tissue and amount of bleeding when the hepatic or splenic bleeding models were made ( P>0.05). It showed that the model was made stably and the hemostasis experiment would not be affected. In the splenic wound model experiment, the time to hemostasis was 255(233, 300)seconds in SURGICEL group and 210(180, 248)seconds in NWL-K group, both of which were significantly shorter than 465(383, 660)seconds in common guaze group ( P<0.05). NWL-K achieved shorter time to hemostasis than SURGICEL ( P<0.05). In the hepatic wound model experiment, the time to hemostasis was 90(85, 110)seconds in SURGICEL group and 70(70, 95)seconds in NWL-K group, both of which were significantly shorter than 250(225 290)seconds in common gauze group ( P<0.05). In the splenic wound model experiment, the bleeding score in NWL-K group and SURGICEL group decreased faster than that in common gauze group ( P<0.05). The difference of bleeding score was significant between NWL-K group and SURGICEL group at 180 seconds ( P<0.05). In the hepatic wound model experiment, the bleeding score in NWL-K group and SURGICEL group decreased faster than that in common gauze group at 50 seconds, 70 seconds and 90 seconds ( P<0.05). The bleeding score in common gauze group and NWL-K group showed significant difference at 30 seconds, 110 seconds and 130 seconds ( P<0.05). For the adhesion evaluation, both the water-absorbency and adhesion to tissue of NWL-K were better than common gauze and SURGICEL. Conclusions:For hepatic and splenic bleeding wounds, compared with other types of gauze, the application of NWL-K can effectively shorten the time to hemostasis and reduce the blood loss. The NWL-K shows high water-absorbency and firm adhesion to bleeding wound.

At present, most of the common medical clothes in clinic are uniform medical clothes, but there is no special clothes for patients in intensive care unit (ICU). In recent years, with the extensive application of critical ultrasound in the field of critical medicine, it is obviously difficult to meet the clinical needs on traditional patients' clothes. Guangdong Provincial People's Hospital designed a patient's clothing for critical ultrasound examination. The left/right chest, lateral chest, groin and abdomen of the patient's clothing body were covered with cloth and marked areas. When critically ill patients need to be examined by ultrasound and electrocardiogram, the site can be quickly located only by removing the cloth. At the same time, it can protect patients' privacy, avoid aggravating the condition due to cold, increase patients' comfort in clothing, and also facilitate medical care. It is worthy popularizing in clinic because of its practicability and novel design.

OBJECTIVETo evaluate the prevalence of leisure-time physical activity and sedentary behaviors among Chinese floating population aged 18-59.

METHODSData was from the Chinese Floating Population Chronic Disease Surveillance (2012). Of the 48 704 subjects aged 18-59 years old, information on frequency and duration of leisure activity was collected by face-to-face interview. Time spent on watching TV, reading, using computers or playing games after work was also calculated.

RESULTS19.4% (95%CI:19.0%-19.7%) of the subjects took part in moderate or vigorous intensity physical activities at least 10 minutes for three days per week, with percentage higher in males than in females and increasing among younger males (P < 0.01). Data showed that it was opposite among females (P < 0.01). Physical activities increased in those with higher education for both males and females (P < 0.01) and showed significant differences on occupations. Among those who engaged in different occupations, subjects working on social service and manufactory presented the top two highest percentages on often engaging in leisure time activities and they spent 4.9 (95%CI:4.8-4.9) hours daily on average in sedentary behavior decreasing along with aging but increasing with having received higher education.

CONCLUSIONThe percentage of taking part in moderate and vigorous activities among floating population was generally low. Prevention should target on floating population, especially on females, those with lower education or at older age.

Adolescent ; Adult ; China ; Female ; Humans ; Leisure Activities ; psychology ; Male ; Middle Aged ; Motor Activity ; Sedentary Lifestyle ; Transients and Migrants ; psychology ; statistics & numerical data ; Young Adult

OBJECTIVETo describe the intake of fruit and vegetables among employed migrant population aged 18 to 59 year-olds in China.

METHODSData from the Migrant Population Survey related to China Chronic Disease and Risk Factor Surveillance that conducted in 170 counties/districts in 31 provinces, 2012, was used. Information on non-communicable diseases and related risk factors among migrant population were collected through face-to-face questionnaire interview, physical measurement and lab tests. A total of 48 704 subjects aged 18 to 59 years old were included in our study. Sample was standardized by age and sex. Information on average daily fruit and vegetables intake, prevalence of low fruit and vegetables intake, grouped by sex, age, industries, and education level were analyzed.

RESULTSThe average daily intakes of vegetables and fruits were 353.7 (95%CI:351.3-356.2) g and 125.1 (95%CI:123.4-126.9) g respectively, among the employed migrant population aged 18-59 years old in China. Prevalence of low fruit and vegetables intake was 44.1% (95% CI:43.5%-44.6% ) among employed migrant population, 46.2% (95% CI: 45.5%-47.0%)for males and 41.2% (95% CI:40.3%-42.0%)for females (χ(2) = 82.19, P < 0.05). Among different professions, the prevalence of low fruit and vegetables intake was the highest among people working in accommodation and restaurants (46.2%, 95%CI:45.0%-47.3%) while the lowest seen among those working in social services (42.5%, 95%CI:41.4%-43.7%,χ(2) = 15.81, P < 0.05). The prevalence of low fruit and vegetables intake showed a decrease along with the increase of education levels (χ(2) = 22.29, P < 0.05).

CONCLUSIONIn 2012, more than 40% of the employed migrant population aged 18 to 59 years old in China had low fruit and vegetables intake. Being male and with low education level were risk factors linked with the higher prevalence of low fruit and vegetables intake.

Adolescent ; Adult ; China ; Diet ; statistics & numerical data ; Employment ; statistics & numerical data ; Female ; Fruit ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Surveys and Questionnaires ; Transients and Migrants ; statistics & numerical data ; Vegetables ; Young Adult

OBJECTIVETo understand the prevalence of cigarette smoking among employed floating population in China and to provide evidence for developing prevention and control measures targeted at cigarette smoking among them.

METHODSOn the basis of the Disease Surveillance Points (DSPs)System and employed distribution among floating population, the China Non- communicable and Chronic Disease Risk Factor Surveillance in 2012 sampled from 170 DSPs, multi-stage stratified equal-sized cluster sampling method was used and stratified by six occupational groups. Cigarette smoking related information among the employed floating population was collected by face-to-face interviews. The analytical method accounted for the complex sampling design.

RESULTSThere were 48 699 subjects, aged 18-59 years old, eligible and included in this analysis among the surveyed employed floating population. Among them, the prevalence of current smoking was 32.5% (95%CI: 32.0%-33.0%). A significantly higher percentage of men 55.3% (95%CI:54.6%-56.0%)relative to women 1.9% (95% CI:1.7%-2.1%)reported current smoking(χ(2) = 2.6, P = 0.103 7). Among men, differences in current smoking rates remained similar across age groups (χ(2) = 2.6, P = 0.103 7), but the current smoking rate tended to be lower with higher education(χ(2) = 140.7, P < 0.000 1). The current smoking rate in men was the highest(58.6% , 95% CI:57.3%-60.0%)in the floating population working in the construction industry. The prevalent of daily cigarette smoking was 27.9% (95% CI: 27.4%-28.4%), with a significantly higher proportion among men 47.8% (95% CI:47.1%-48.5%) than among women 1.3% (95%CI:1.1%-1.4%). Among daily smokers, the mean number of cigarettes smoked was 15.6(95%CI:15.5-15.8)per day(men:15.7 per day; women: 10.3 per day). The number was higher in men 15.7(95% CI:15.6-15.9)than in women 10.3(95% CI:9.3-11.3). Among daily smoking men, the daily consumed cigarettes number increased with the age increased (t = 34.89, P < 0.000 1), whereas the daily consumed cigarettes number decreased with the increase of education level (t = -14.63, P < 0.000 1). The daily consumed cigarettes number in men was the highest (18.2, 95%CI:17.9-18.6)in the floating population working in the construction industry. There were 47.1% of the daily smokers who smoked more than 20 cigarettes per day in the floating population aged 18-59, with a higher percentage among men (47.6%) than women (21.9%). The percentage in men increased with age and education level and the heavy smoking rate was the highest in the construction industry (60.4%). Among current smokers, the percentage of attempting to quit was 10.3% (95%CI: 9.7%-10.8%). A higher proportion of women 14.8% (95% CI:11.1%-18.5%), compared to men 10.1% (95% CI:9.6%-10.7%), reported attempting to quit. The rate of attempting to quit among current smokers increased with age. No significant difference in prevalence of attempting to quit by education level or occupation was seen. The percent of successfully quitting smoking was 6.1% (95%CI:5.7%-6.5%). The proportion was higher in women 7.2% (95%CI:4.6%-9.8%)than in men 6.1% (95%CI:5.7%-6.5%). The percentage of quitting smoking successfully increased with age (χ(2) = 269.0, P < 0.000 1). The percent of people who exposed to secondhand smoking was 68.7% (95%CI: 68.1%-69.3%). The percent was higher among men 76.4% (95%CI:75.5%-77.3%) than in women 64.0% (95%CI:63.2%-64.9%).

CONCLUSIONSmoking was more common among men in the employed floating population aged 18-59 years old, especially in the construction industry. Low percent was seen among those who attempting to quit, and the ones who successfully quit were very few.

Adolescent ; Adult ; China ; epidemiology ; Employment ; statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Smoking ; epidemiology ; psychology ; Transients and Migrants ; psychology ; statistics & numerical data ; Young Adult

OBJECTIVETo understand the drinking behaviors and patterns among floating population in China.

METHODSFloating population were selected through multistage clustering sampling method, stratified by 6 major industries in 170 counties and districts from 31 provinces/autonomous regions, and Xinjiang Construction Corps, in mainland China. Design-based methods were adopted to analyze the drinking behavior in subpopulations.

RESULTSA total of 48 697 floating population aged 18-59 years were included in the study. The overall prevalence rate of drinking was 51.7% with 71.9% in men and 24.7% in women, in the last 12 months. Among those who ever drank, the weekly drinking prevalence and daily alcohol intake were 53.9% and 18.7 g in males while 16.7% and 4.1 g in females, respectively, among those floating population. Weekly drinking prevalence rates, for both genders, increased along with the increase of age (P < 0.01), but declining with having higher education level (P < 0.01). Among male drinkers, daily alcohol intake increased with age(P < 0.01) but declining with those having higher education (P < 0.01). Prevalence rates on excessive drinking, hazardous drinking and harmful drinking among male drinkers were 23.6% , 6.6% and 6.9%, respectively, but among female drinkers the figures were 6.3% , 2.3% and 1.5% , respectively. More male and older drinkers had excessive drinking, hazardous drinking or harmful drinking than the younger drinkers (P < 0.01), while less male drinkers in those having lower education (P < 0.01). 71.2% male and 33.1% female drinkers experienced at least once binge drinking in the last 12 months. Distribution of binge drinking frequencies were statistically different among male drinkers by age groups, education levels, or occupation they engaged in (P < 0.01). Among all the 6 occupations, floating population from the construction industry had the highest prevalence rates on items as weekly drinking, daily alcohol intake and prevalence of unhealthy drinking behaviors, except for hazardous drinking behaviors.

CONCLUSIONDrinking behavior was prevalent among floating population in China. Significant difference was seen between genders. Unhealthy drinking behaviors varied greatly among male drinkers at different age groups or education levels as well as among those working in the different industries.

Adolescent ; Adult ; Alcohol Drinking ; epidemiology ; psychology ; China ; epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Transients and Migrants ; psychology ; statistics & numerical data ; Young Adult

OBJECTIVE: To prepare customized porous silicone orbital implants using embedded 3D printing and assess the effect of surface modification on the properties of the implants. METHODS: The transparency, fluidity and rheological properties of the supporting media were tested to determine the optimal printing parameters of silicone. The morphological changes of silicone after modification were analyzed by scanning electron microscopy, and the hydrophilicity and hydrophobicity of silicone surface were evaluated by measuring the water contact angle. The compression modulus of porous silicone was measured using compression test. Porcine aortic endothelial cells (PAOECs) were co-cultured with porous silicone scaffolds for 1, 3 and 5 days to test the biocompatibility of silicone. The local inflammatory response to subcutaneous porous silicone implants was evaluated in rats. RESULTS: The optimal printing parameters of silicone orbital implants were determined as the following: supporting medium 4% (mass ratio), printing pressure 1.0 bar and printing speed 6 mm/s. Scanning electron microscopy showed that the silicone surface was successfully modified with polydopamine and collagen, which significantly improved hydrophilicity of the silicone surface (P < 0.05) without causing significant changes in the compression modulus (P > 0.05). The modified porous silicone scaffold had no obvious cytotoxicity and obviously promoted adhesion and proliferation of PAOECs (P < 0.05). In rats bearing the subcutaneous implants, no obvious inflammation was observed in the local tissue. CONCLUSION Poprous silicone orbital implants with uniform pores can be prepared using embedded 3D printing technology, and surface modification obviously improves hydrophilicity and biocompatibility of the silicone implants for potential clinical application.
Animals ; Rats ; Swine ; Silicon ; Orbital Implants ; Endothelial Cells ; Porosity ; Silicones ; Printing, Three-Dimensional