1.Observation on the effect of cetylpyridine chloride gargle in the treatment of oral Candida infection
Chinese Journal of Biochemical Pharmaceutics 2017;37(7):269-270,273
Objective To investigate the clinical efficacy of cetylpyridinium chloride gargle in the treatment of oral candidiasis.Methods Collected 45 cases of oral candidiasis patients admitted in our hospital from April 2015 to April 2017.Among them, 24 patients were treated with cetylpyridinium chloride gargle and treated as observation group.Rinse treatment in 21 cases, set as the control group.The oral pain score, mucosal atrophy score and mucosal erythema score were compared between the two groups.The HAMA anxiety scale and HAMD depression scale were used to evaluate the psychological stress.The HAMA score, HAMD score, blood glucose and blood glucose were compared between the two groups.Insulin levels were compared between the two groups of patients after oral mucosal examination positive rate and the incidence of adverse reactions.Results After treatment, the oral pain score, mucosal atrophy score and mucosal erythema score were significantly lower in the observation group than in the control group, the difference was statistically significant(P<0.05).The HAMA score, HAMD score and blood glucose level were significantly lower in the observation group than in the control group, the insulin level was higher than the control group, the difference was statistically significant(P<0.05).The positive rate was 20.83%(5/24)in the observation group and 52.38%(11/21)in the control group.The positive rate of oral mucosal examination in the observation group was significantly lower than that in the control group, the difference was statistically significant(P<0.05).There were no obvious adverse reactions during the treatment group.In the control group, only one case of oral mucosal congestion was found, but it was tolerable and disappeared after treatment.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The use of cetylpyridinium chloride gargle in the treatment of oral candidiasis can relieve oral pain, mucosal atrophy, erythema symptoms and stress state, effective control of oral infection, and no significant adverse reactions、high safety.
2.Expressions of Toll-like receptors 2 and 4 in skin lesions and peripheral blood from patients with chloasma
Yinjuan WANG ; Hua GU ; Meihua GUO ; Ying TU ; Li HE
Chinese Journal of Dermatology 2015;48(2):100-103
Objective To investigate the relationship of Toll-like receptors (TLRs) 2 and 4 with the occurrence of chloasma.Methods Peripheral blood samples were collected from 40 patients with chloasma and 40 healthy human controls,and skin samples were also collected from the lesions of 10 of the patients and normal skin of 10 of the healthy controls.Real time (RT)-PCR was performed to measure the mRNA expressions of TLR2 and TLR4 in skin lesions and blood samples.An immunohistochemical test was conducted to observe the expressions of TLR2 and TLR4 in skin lesions.Statistical analysis was carried out by t test.Results The expressions of TLR2 and TLR4 mRNAs were both significantly higher in skin lesions of the patients than in normal skin of the controls (9.72 ± 2.93 vs.5.10 ± 2.69,t =3.67,P< 0.01; 9.52 ± 2.88 vs.4.77 ± 1.90,t =4.36,P< 0.01),while no significant difference was found in the mRNA expressions of TLR2 or TLR4 in peripheral blood between the patients and controls (both P > 0.05).As the immunohistochemical test revealed,TLR2 was absent in both the epidermis and vascular endothelial cells in 6 normal control skin samples,weakly expressed in the basal layer of the epidermis but absent in vascular endothelial cells in 4 normal skin samples,and no TLR4 expression was observed in either the epidermis or vascular endothelial cells in these control skin samples.Among the 10 skin samples from chloasma lesions,3 showed TLR2 expression in the whole epidermis,7 in both basal cell layer and prickle cell layer but not in vascular endothelial cells in the superficial dermal layer,all showed strong TLR4 expression in the basal cell layer and weak TLR4 expression in the prickle cell layer,and 3 exhibited TLR4 expression in vascular endothelial cells in the superficial dermal layer.Conclusion TLR-mediated immune responses in local skin might be related to the occurrence of chloasma.
3.Influence of Baihe Zhimu Decoction in levels of key factors of CaM signaling pathway in hippocampus tissue of rats with depression and its antidepressant mechanism
Li YUAN ; Qi LIU ; Zhe FAN ; Deshun LI ; Jianhong WU ; Zhihua ZHANG ; Yinjuan LYU ; Yongming HAN
Journal of Jilin University(Medicine Edition) 2016;42(4):704-710
Objective:To study the antidepressant effect of Baihe Zhimu decoction (BZD)and its influence in the key factors (CaM,CaMKⅡ,CREB)of CaM signaling pathway in hippocampus of the rats with depression,and to explore the antidepressant effect of BZD. Methods:Fifty rats were divided into control group,model group, fluoxetine group,low and high doses of BDZ groups (n = 10).Expect for control group,all the rats in other groups were made depression models by means of chronic unpredictable mild stress along with isolated raising,for 21 d.Then the rats were fed with NS, fluoxetine (1.8 mg · kg-1 ), and BZD (1.5 and 3.0 g · kg-1 ), respectively;for 28 d.The learning and memory ability,autonomous activities and the fixed time in 5 min of the rats were tested by Morris water amaze,Open-field Test and Forced Swimming Test respectively. The damage and repair status of hippocampal neurons were observed by Nissl staining method;the expression levels of CaM,CaMKⅡ protein,CREB mRNA in hippocampus of the rats were detected by Western blotting and RT-PCR method. Results:Compared with model group,the total time of rats in the platform quadrant of Morris water maze in BZD groups and fluoxetine group,the total distance and the number of crossing platform were increased (P <0.05 or P <0.01),and the time of first crossing platform were shortened (P <0.01);the total scores in open field test were increased (P <0.01),the fixed time with 5 min in the forced swimming test was shortened (P <0.05 or P <0.01).Compared with fluoxetine group,the fixed time within 5 min of the rats in swimming test was shortened (P <0.05).The result of Nissl staining showed that the hippocampal neuron injury in BZD groups and fluoxetine group was improved compared with model group.The molecular test results showed that the CaM and CaMKⅡprotein expression levels in hippocampus of the rats in BZD groups and fluoxetine group were increased compared with model group (P < 0.05 or P < 0.01).Compared with model group,the CREB mRNA expression levels in fluoxetime group and BZD groups were increased (P < 0.05 or P < 0.01).Conclusion:BZD has antidepressant effect and can improve the hippocampal neuron injury of the rats with depression and its mechanism is related to increasing the expression levels of CaM,CaMKⅡ and CREB in hippocampus CAM signaling pathway of the rats.
4.The relation of early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient and body weight changes following intensification therapy of insulin
Lixin YANG ; Yaping ZHANG ; Na MI ; Ye WANG ; Qinfang ZHU ; Weiliang HAN ; Yinjuan LI
Clinical Medicine of China 2009;25(10):1061-1063
Objective To explore the relation of early time secretion function of Beta cell in newly diag-nosed type 2 diabetic patient and the changes of body weight following intensification therapy of insulin. Methods 237 newly diagnosed type 2 diabetic patients were divided into 1 kg lower group, the 1-5 kg group, the 5 kg above group. The maximum body weight and waist circumference were recorded. The present body weight and waist circum-ference were measured according to OGTT study, meanwhile,30 minuets blood sugars, the insulin and the C-peptide (C-P) level and the blood pressure(BP) and the insulin resistance index (HOMA-IR), the early insulin secretion index (△I30/△G30) was calculated. All cases were treated for 14 days. Results Early time secretion function of Beta cell in the group keeping above lose weight 5 kg was the worst, after treatment insulin secretion level were in-creased 1.12 times and 1.86 times in 1 kg lower group than in the 1-5 kg group and above 5 kg group. Conclusions Early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient is correlated with the maxi-mum body weight decrease.
5. A review and update of the potential impact of the built environment on physical activity and dietary habits
Yinjuan DUAN ; Liming LI ; Jun LYU
Chinese Journal of Epidemiology 2019;40(4):475-480
With the accelerated urbanization process, there are growing interests in the potential impact of neighborhood built-environment on residents’ physical activity and dietary habits. In this paper, we introduced the concept of the built environment and the ways to assess the built-environment related to physical activity and dietary habits. We reviewed papers on the association of the built-environment with physical activity and dietary habits. Improvement of the built-environment is expected to reduce the health burden caused by insufficient physical activity and unhealthy dietary habits. As this field is still at its initial stage, there are many questions to be explored. We then discussed the challenges for this field and made some suggestions for future study.
6. Comparison of the effects of caffeine citrate administering at different time on outcome and neuro-development of premature infants
Xiaonan LI ; Falin XU ; Yaxuan LIU ; Wenli DUAN ; Mengdi LIU ; Jiaxin LIU ; Yinjuan WANG
Chinese Pediatric Emergency Medicine 2020;27(2):129-133
Objective:
To investigate the effect of caffeine citrate administering at different time on outcome and neurodevelopment of premature infants.
Methods:
A total of 113 preterm infants with gestational age less than 32 weeks and birth weight less than 1 500 g who were hospitalized and treated in the neonatal intensive care unit from January 2018 to June 2018 were enrolled.According to the time when caffeine citrate treatment was started, they were divided into early treatment group(≤1 days) with 53 infants and late treatment group(1 to 10 days) with 60 infants.A retrospective analysis was performed for their clinical data.The perinatal conditions, treatment process and clinical outcomes of the two groups were compared and the neurological development was followed up at 12 months old.
Results:
Compared with the late treatment group, the early treatment group had a significantly shorter durations of mechanical ventilation time, oxygen therapy time, hospitalization days and a significantly lower incidence of bronchopulmonary dysplasia, patent ductus arteriosusand intraventricular hemorrhage or periventricular leukomalacia, and there were significant differences between two groups(
7. The value of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced T1 mapping in dysplastic nodule and hepatocellular carcinoma with different degrees of differentiation
Xiali QIN ; Zhongkui HUANG ; Liling LONG ; Yinjuan GAO ; Wenmei LI ; Zhipeng ZHOU
Chinese Journal of Radiology 2018;52(8):603-607
Objective:
To explore the value of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA) enhanced MRI T1 mapping in diagnosing and distinguishing dysplastic nodule (DN) and hepatocellular carcinoma (HCC) with different degrees of differentiation.
Methods:
A retrospective study in the first affiliated Hospital of Guangxi Medical University from September 2015 to December 2017 was conducted. Seventy-one patients with HCC or DN (a total of 79 lesions) that confirmed by biopsy or surgical pathology findings. Seventy-nine lesions were divided into DN (
8.Analysis of neonatal deaths in different medical institutions in Henan province
Qiujing XING ; Yinjuan WANG ; Wenli LI ; Huifang DONG ; Ling WANG ; Fang JIANG ; Falin XU
Chinese Pediatric Emergency Medicine 2020;27(8):591-596
Objective:To investigate the mortality and causes of death in neonates from different medical institutions in Henan province.Methods:A retrospective analysis was performed on the death cases of 62 different medical institutions in 18 cities of Henan province in 2018, in order to compare the differences of neonatal mortality, age of death and the causes of death between maternal and child health care hospitals and general hospitals.Results:(1) A total of 80 780 newborns were admitted to 62 hospitals and 311 neonates died with a mortality rate of 3.85‰.A total of 33 339 newborns were admitted to 24 maternal and child health care hospitals, and 102 neonates died with a mortality rate of 3.06‰.Among them, 54 cases(52.9%) were premature infants and 48 cases(47.1%)were full-term infants.A total of 47 441 newborns were admitted to 38 general hospitals, and 209 neonates died with a mortality rate of 4.41‰.Among them, 111 cases(53.1%) were premature infants and 98 cases (46.9%) were full-term infants.Neonatal mortality in general hospitals was higher than that in maternal and child health care hospitals( P<0.05). (2) Neonatal death mainly occurred within one week after birth, especially within the first day.There were 67 cases of death(65.7%) in 24 maternal and child health care hospitals within the first day, including 34 cases (50.7%) of full-term infants and 33 cases (49.3%)of premature infants.And there were 87 cases of death(41.6%) in 38 general hospitals within the first day, including 50 cases (57.5%) of premature infants and 37 cases (42.5%) of full-term infants.Neonatal mortality within the first day after birth in maternal and child health care hospitals was higher than that in general hospitals( P<0.05). (3) The leading causes of neonatal death were non-infectious pulmonary diseases(128 cases, 41.2%), followed by birth asphyxia(73 cases, 23.5%) and infection(51 cases, 16.4%), but the causes of death in sequence varies from maternal and child health care hospitals and general hospitals.(4) For early death (within one week after birth) in both general hospitals and maternal and child health care hospitals, the main causes were birth asphyxia for full-term neonates, and pulmonary diseases(mainly respiratory distress syndrome)and birth asphyxia for premature infants.For late-stage death (2-4 weeks after birth) of neonates, infection was the leading cause in both term and preterm infants in general hospitals.For maternal and child health hospitals, the main causes of death for full-term infants were infection, and pulmonary diseases (mainly pulmonary hemorrhage and respiratory distress syndrome) for premature infants. Conclusion:There are some differences between maternal and child health care hospitals and general hospitals in neonatal mortality, mortality within the first day after birth, and causes of death.Therefore, it is necessary to strengthen the corresponding software and hardware constructions for newborns in different medical institutions to further reduce the neonatal mortality rate.
9.CBCT study on the safe location of palatal microscrew implant anchorage nail between maxillary first and second molars
LI Xinghan ; LI Jun ; MENG Yitong ; TANG Yulong ; XU Jialin ; YANG Ying ; DONG Yinjuan ; ZHANG Xiaodong
Journal of Prevention and Treatment for Stomatological Diseases 2022;30(1):39-44
Objective:
Conebeam CT (CBCT) was used to measure the palatine between the maxillary first and second molars. The proximal and distal palatal widths of the maxillary first and second molar and the palatal mucosal thickness and bone tissue thickness when microscrew implant anchorage nail were implanted at different angles provided a reference for the clinical selection of microscrew implant placement.
Methods:
The image data of 90 adult patients were selected as the research object, and the jaw bone was reconstructed by scanning. In maxillary palatine, selection of distances at 12 mm, 14 mm, 16 mm, and 18 mm from the palatal apex of maxillary first molar between the maxillary first and second molar were used as measurement, measured the proximal and distal palatal widths of maxillary first and second molar and the palatal mucosal thickness and bone tissue thickness when microscrew implant anchorage nails were implanted at 30 °, 45 °, 60 °, and 90 °. SPSS 26.0 software was used for one-way ANOVA and LSD pair comparison.
Results:
The larger the angle of the microscrew implant anchorage nail was, the smaller the proximal and distal medial widths between the maxillary first and second molar, and the difference was statistically significant (P < 0.05). Compared with the 90° direction, the proximal and distal medial widths of the microscrew implant anchorage nail were larger in the 60° direction. The greater the angle of implantation, the smaller the mucosal thickness and the greater the bone tissue thickness, and the results showed a significant difference (P < 0.001). Compared with the direction of 30° and 45°, the mucosal thickness at the direction of 60° was smaller, and the bone tissue thickness was larger. The higher the position of the microscrew implant anchorage nail, the greater the width of the proximal and distal medial, and the difference was statistically significant (P < 0.05). Compared with the positions 12 and 14 mm from the palatal tip, the proximal and distal medial widths of the microscrew implant anchorage nail were larger. The higher the implant position was, the greater the mucosal thickness and the smaller the bone tissue thickness. The results showed a significant difference (P < 0.001). Compared with the position of 18 mm from the palatal tip of the maxillary first molar, the mucosal thickness was smaller and the bone tissue thickness was larger.
Conclusion
It is most appropriate to implant microscrew implant anchorage nail at least 10 mm in length in the direction of 60° at the palatal apex 16 mm from the maxillary first molar in palatine between the first and second molar.
10. Analysis of neonatal deaths in critical neonatal treatment centers at different levels in Henan province
Qiujing XING ; Yinjuan WANG ; Wenli LI ; Huifang DONG ; Ling WANG ; Fang JIANG ; Falin XU
Chinese Journal of Applied Clinical Pediatrics 2019;34(20):1570-1575
Objective:
To investigate the death status and cause of death of newborns in critical care centers at different levels in Henan province.
Methods:
Retrospective analysis was performed on the death cases at 85 critical neonatal treatment centers in 18 cities of Henan province from January to December 2018, and the similarities and differences in neonatal mortality, age of death and causes of death among cities and county-level critical neonatal care centers were compared.
Results:
(1) A total of 99 832 neonates were admitted to 85 hospitals, and 318 neonates died, with a mortality rate of 3.19‰.A total of 42 066 neonates were admitted to 21 municipal hospitals, and 194 neonates died, with a mortality rate of 4.6‰.Among them, 109 cases (56.2%) were premature infants (14 cases were of 28 weeks, 70 cases were of 28-34 weeks, 25 cases were of >34-37 weeks), and 85 cases (43.8%) were full-term infants.A total of 57 766 neonates were admitted to 64 county-level hospitals, with 124 deaths and a mortality rate of 2.1‰.Among them, 67 cases (54.0%) were full-term infants, 57 cases (46.0%) were premature infants (9 cases were of 28 weeks, 34 cases were of 28-34 weeks and 14 cases were of >34-37 weeks). The mortality rates at muni-cipal hospital were higher than those at the county-level hospitals, and the difference was statistically significant (