Objective To research the influence kidney-yang deficiency on rat' s gastric antrum and small intestinal mucosa tissue microstructure' s change.Methods The rats were cut off bilateral adrenal three-quarters to establish the model rats with deficiency of kidney-yang,which were randomly divided into a model group and a Shenfu decoction group at 4 weeks after operation.The sham operation group was the same as model group except without cutting rats bilateral adrenal and setting as a control group.The Shenfu decoction group was given suspension liquid of Shenfu decoetion by lavage,and both the control group and model group were given physiological saline of the same capacity for 4 weeks.Each rat gastric antrum and small intestinal mucosa's organization structure by conventional HE slice was observed.Results ① The sham operation group rats' gastric and intestinal mucosa were pink,shiny and elastic by macroscopic observation.Compared with the sham operation group,the gastric and intestinal mucosa of the model group became thinner,dimmer and less elastic.Compared with the model group,the gastric and intestinal mucosa of the Shenfu decoction group were a bit thicker,shinier and more elastic.② The results of the light microscope showed that:The gastric antrum and intestinal mucosa's tissue structure were normal.Compared with the sham operation group,the antrum mucosa tissue's cell gap of the model group became larger,besides the mucous glands had different degrees of alignment disorders,and a large number of vacuolar degeneration Appeared.The intestinal mucosa tissue villus edge was irregular,partial shedding of the epithelium fell offand deleted.Compared with the model group,the antrum mucosa tissue's cell gap of the Shenfu decoction group became smaller,the mucous glands cells arranged more regular,and the vacuolar degeneration had reduced.The intestinal mucosa tissue villus edge was more regular,and intestinal mucosal epithelial tissue was more complete.Conclusion The pathological changes were emerged in kidney-yang deficiency rat models.