Stroke is the most common disease of the central nervous system, with high disability and mortality, which seriously affects the quality of life of patients and causes a huge disease burden. However, the overall treatment effect is still unsatisfied at present. Myeloperoxidase (MPO), a kind of peroxidase derived from neutrophils, may play an important role in stroke development through many ways, and has great potential in early diagnosis, clinical treatment and prognosis evaluation of stroke. This article reviews the research progress of MPO in stroke, aiming to provide new ideas for better diagnosis and treatment of stroke in clinic.

Objective　To investigate the relationship between histological classification of lung cancer and protein tyrosine phosphatase. Methods　The expression of protein tyrosine phosphatase in bronchial epithelia from 34 patients with benign pulmonary lesions and 121 patients with primary pulmonary carcinoma was examined by immunohistochemical staining method. Results　The positive rate of protein tyrosine phosphatase expression was 95.03％±2.10％ in 34 patients with benign pulmonary lesions, 43.59％±14.41％ in 121 patients with primary pulmonary carcinoma; 47.57％±16.26％ in 46 patients with adenocarcinoma, 40.59％±14.04％ in 48 patients with squamous cell carcinoma, 42.13％±9.84％ in 27 patients with adenosquamous carcinoma; 31.63％±10.34％ in 21 patients with poor differentiated squamous cell carcinoma, 41.39％±9.35％ in 18 patients with intermediate differentiated squamous cell carcinoma, 59.90％±8.61％ in 9 patients with well differentiated squamous cell carcinoma; 34.14％±12.53％ in 16 patients with poor differentiated adenocarcinoma, 52.10％±12.19％ in 26 patients with intermediate differentiated adenocarcinoma, and 63.05％±15.84％ in 4 patients with well differentiated adenocarcinoma. A significant difference of protein tyrosine phosphatase positive expression was observed between benign pulmonary lesions and primary pulmonary carcinomas, and between poor differentiated primary pulmonary carcinomas and well differentiated primary pulmonary carcinomas (P＜0.01 or P＜0.05). Conclusion　Detection of protein tyrosine phosphatase may be helpful to differentiate pulmonary lesions from lung cancer and be regarded as one of the indices in predicting the prognosis of patients with primary pulmonary carcinomas.