Objective To investigate the effect of Q laser on microcirculation structure and skin barrier function of subcutaneous tissue in patients with pigmented dermatosis.Methods The Q laser was used in treatment of 100 cases of pigmented skin diseases,and the skin barrier function was detected before and after treatment in patients with lesions,including sebum content,transepidermal water loss of skin moisture;difference of skin barrier function in patients was analyzed before and after treatment;the structural change of microcirculation were observed before and after treatment of skin tissue;the clinical curative effects of patients after treatment were analyzed,and then the patients were followed up to evaluate the recurrence rate.Results After the treatment of patients with skin lesions,barrier function was compared with a significant difference.Compared with before treatment,rise,oil content of skin lesions in patients with skin moisture content,transepidermal water loss of skin moisture of the patient improved obviously after treatment.The effective rate was 94 ％ in the 100 cases of skin diseases.No hypopigmentation or scar occurred in the patients.And the follow-up showed that the recurrence rate was relatively low.Conclusions Adjusted Q laser may participate in the improvement of microcirculatory disturbances through special mechanisms,so as to regulate the skin barrier function of patients.

Objective To compare the therapeutic efficacy of whey protein powder in peritoneal dialysis hypoproteinemia patients.Methods From August 2019 to August 2020,100 patients with peritoneal dialysis hypoproteinemia from the Peritoneal Dialysis Center of the First Affiliated Hospital of Xi'an Jiaotong University were investigated.The patients were separated into 2 groups randomly;the study group were administered whey protein powder and the control group with high protein food.After 32 weeks of treatment,biochemical and biometric indices including hemoglobin(Hb),albumin(ALB),prealbumin(PA),triglyceride(TG),total cholesterol(TC),phosphorus(P),low density lipoprotein(LDL),high density lipoprotein(HDL),serum creatinine(Scr),blood urea nitrogen(BUN),estimated glo-merular filtration rate(eGFR),total spKt/Vurea(TKt/V),total creatinine clearance rate(TCcr),hand grip strength(HG),triceps skinfold(TSF),arm circumference(AMC),mid-arm muscle circumference(MAMC)were compared between groups.Results Compared with 0 week,at 16 and 32 weeks,ALB,PA,and HG were significantly increased in the study group(P＜0.05).Compared with the control group,ALB,PA,and HG increased significantly at 16 and 32 weeks in the study group(P＜0.05).There were no significant differences in TG,TC,HDL,LDL,eGFR,TKt/V,and TCcr at 0,8,16,and 32 weeks between the control and study groups(P＞0.05).Conclusion For patients with peritoneal dialysis hypoproteinemia caused by insufficient protein intake or excessive protein loss,the addition of whey protein during peritoneal dialysis can significantly improve the nutritional status of patients,with greater efficacy than a high protein diet alone.