Objective To investigate multi-slice spiral CT manifestations and its diagnostic value of extragastrointestinal stromal tumor(EGIST).Methods CT data in 19 patients with EGIST proved pathologically were retrospectively reviewed.Results Of the 19 cases,the lesions located in reteoperitoneum in 8 cases,adrenal,greater omentum,omentum and mesentery in one case respectively,mesentery in 4 cases,and abdominal cavity in 4 cases.2 cases were benign,4 cases were potential malignant,and 13 cases were malignant.The size of tumors ranged 4.1～35 cm.The tumors were round or oval in 5 cases,lobulated in 5 cases and irregular in 9 cases.The tumors in 4 cases were uniform density on plain CT scans,1 case of uniform and moderate enhancement,1 case of non-uniform enhancement,2 cases of apparent enhancement as ring on contrast-enhanced CT scans;15 cases showed unhomogeneous density,on contrast-enhanced scans,moderate or remarkable enhancement was seen in the parenchyma of the tumor,while no enhancement was revealed in the necrosis and cystic areas of the tumors.Conclusion EGIST have certain imaging characteristics and MSCT was valuable in diagnosing and differential diagnosing EGIST.

The binding capacity (R_o) and apparant dissociation constant (K_d) of glucocrticoid binding sites in hepatic cytosol of normal and scalded rats were measured by pseudoscatchard analysis. Compared with control group, the levels of Ro of glucocorticoid receptor was significantly decreased 1 h after scalding, partialy recovered at 12h after scalding and fully recovered at 24 h after scalding. The levels of low-affinity glucocorticoid binding sites were also decreased 12 h after scalding, but had no statistical significance. The possible significance of these results has been discussed.

Purpose To investigate the MSCT diagnosis and differential diagnosis of rare pancreatic tumors.Materials and Methods The MSCT features were analysied respectively of 31 cases with pancreatic tumors confirmed by surgery and pathology.Results There were serous cystadenoma in 7 cases,mucinous cystadenoma in 9 cases,mucinous cystadenocarcinoma in 1 case,solid-pseudopapillary tumor in 8 cases,islet cell tumor in 4 cases,carcinoid tumor in 1 case and intraductal papillary adenocarcinoma 1 case.The MSCT appearances were different each other.Conclusion MSCT is very helpful in diagnosis and differential diagnosis for the rare pancreatic tumors.

Several cytokines which play key role in asthma patients with chronic inflammation and reconstruction of air duct,are important targets for anti-asthma agents.In this review,we summarize the latest advancement of anti-asthma agents which targeted for cytokines(interleukins,TNF,eotaxin)and investigation development of new anti-asthma agents emerged in recent years.

Objective To investigate the value of distinguishing small clear cell renal cell carcinoma and high-attenuation renal cysts by applying unenhanced CT value and homogeneity of the esions.Methods Retrospective analysis of 38 cases of small renal cell carcinoma confirmed by operation and pathology and 58 cases of high-attenuation renal cyst that were confirmed by enhanced CT,and measured CT value and homogeneity of each mass,and did statistical analysis for corresponding datas.Results The CT value of small clear cell renal cell carcinoma was (35.5±10.1)HU (range 20-60.3 HU).The CT value of high-attenuation renal cysts was (70±1 5.2)HU (range 29-95 HU).Difference of the two groups had statistical significance (P <0.001).For high-attenuation re-nal cysts,uniform density often can be seen(47 cases,81.03%).For small clear cell renal cell carcinoma,uneven density often can be seen (29 cases,76.32%).Difference of the two groups had statistical significance (P <0.001).When optimal cut-off of CT value determined by ROC was 5 1.5 HU,the sensitivity and specificity were 89.7% and 92.1%,respectively.Conclusion Unenhanced CT may be helpful in distinguishing small clear cell renal cell carcinoma and high-attenuation renal cysts,which can provide reasona-ble suggestions on the next identification examinations.

Objective:To observe the clinical efficacy of warm acupuncture in the treatment of diabetic peripheral neuropathy and its effects on the conduction velocity of the tibial nerve and common fibular nerve.Methods:Fifty.two subjects were evenly randomized into two groups and treated by conventional therapy;in addition,the control group was given mecobalamin injection at 500 μg,once a day for four weeks,and treatment group was given warm acupuncture,6 times a week for 4 weeks.The clinical efficacy and the conduction velocity of the tibial nerve and common fibular nerve were observed and compared between the two groups.Results:After four-week treatments.the total effective rate Was 88.5% in the treatment group and 61.5% in the control group,with a higher rate in the treatment group than in the control group (P＜0.05):the conduction velocity of tibial nerve and common fibular nerve Was higher in both groups(P＜0.05),with higher conduction velocity in the treatment group than in the control group (P＜0.05).Conclusion:Warm acupuncture is quite effective to treat diabetic peripheral neuropathy and to improve nerve velocity.

Objective To explore the relationship between retinal nerve fiber layer (RNFL) thickness and central corneal thickness (CCT) in myopia eyes.Methods 91 cases (91eyes) were selected from ophthalmological outpatients including 28cases with low myopia ( spherical equivalence [ SE ] ＞ -3.0D), 33 cases with moderate myopia (SE -0.3D ～ -6.0D) and 30 cases with high myopia (SE ＜ -6.0D).All patients received ocular standard examination including intraocular pressure, refraction, slitlamp biomicroscopy and fundus examination.Other ocular diseases except refractive error were excluded.RNFL thickness and CCT were measured by RTVue Fourior-OCT ( Optovue Inc, USA).Refraction diopter was shown as SE.Results The mean RNFL thickness and CCT was ( 108.5 ± 10.1 ) μm, (524.7 ±36.8)μm respectively.These were no significantly different among low, moderate and high myopia ( P ＞ 0.05 ).Temporal RNFL thickness( tl1 ,tu1 ) was significantly positive related with CCT( r =0.281,0.093 of tl1, r= 0.352,0.167 of tu1 respectively in single and multiple variable analysis; P ＜ 0.05 ), nasal ( nl2, nu2)and inferior nasal RNFL thickness( in2,in1 )was significantly positive related with SE( P ＜0.05), inferior temporal RNFL thickness( it2)was significantly negative related with SE( P ＜0.05), and RNFL thickness in other regions were not significant related with CCT and SE ( P ＞ 0.05 ) in single and multiple variable regressive analysis.Conclusion Relationship between RNFL thickness of local paradisc region and CCT in myopia eyes suggested that CCT should be correlative with some sensible structural parameters in glaucomatous neuropathy and might be important in the diagnosis and therapy of glaucoma.

Purpose:To study the connection between the blocking of N-acetylglucosaminyltransferase V(GnT-V) and endoplasmic reticulum stress(ER stress). Methods:The recombinant plasmid expressing siRNA of GnT-V was constructed and transfected into SMMC-7721. The key molecules such as GRP78,XBP1 and PERK during ER stress was analyzed in mRNA and protein levels. Results:GRP78 mRNA and protein levels were upregulated, the spliced forms of XBP1 mRNA and protein appeared and ER eIF2? kinase PERK was activated. Conclusions:These results suggest the blocking of GnT-V in SMMC-7721 induces cellular ER stress.

Objective To evaluate the relationship between Helicobacter pylori antigen in saliva and the activity of gastritis and like intestinal metaplasia(IM)or atypical hyperplasia(AH).Methods From June 2004 to June 2005 Helicobacter pylori antigen were detected in saliva of 246 persons by enzyme-linked immunosorbent assay(ELISA),and the Hp-positive rates in saliva in patients with different gastritis were compared.Results The Hp-positive rate in saliva in patients with active chronic gastritis was 74.29%(26/35),which was significantly higher(P

Objective To find out the difference in expression of glial fibrillary acidic protein and neuron-specific enolase in hippocampi and olfactory bulb of Alzheimer's disease rats,and the relationship between olfactory and Alzheimer's disease.Methods Adult rats,the expression of GFAP and NSE in hippocampi and olfactory bulb was measured by immuhistochemical after a single intracerebroventricular injection of ?-amyloid peptide,and change of these protein in olfactory.Results Comparing the hippocampi and olfactory of model and control,the expression of GFAP in model group increased evidently,the expression of NSE descended animals.Conclusion There is significant difference in olfactory system between Alzheimer's disease model and control group rats.