INTRODUCTION: Endometriosis (EMS) is a common gynaecological disorder linked to metabolic disturbances. However, evidence on the associations between lipid accumulation product (LAP) and visceral adiposity index (VAI) with the risk of EMS remains limited. This study aimed to explore the potential associations between LAP, VAI and EMS. METHOD: Data were obtained from the 1999-2006 National Health and Nutrition Examination Survey (NHANES), including a total of 2046 samples. Weighted multivariable logistic regression models and smoothed curve fitting were used to assess the associations between LAP, VAI and EMS. Additionally, subgroup analyses and interaction tests were conducted to evaluate intergroup differences in the associations between LAP, VAI and EMS. RESULTS: In the fully adjusted model, higher Log2 LAP (odds ratio [OR] 1.256, 95% confidence interval [CI] 1.102-1.431, P=0.0014) and Log2 VAI (OR 1.287, 95% CI 1.105-1.498, P=0.0022) were significantly associated with increased EMS risk. Participants in the highest quartile of Log2 LAP (OR 1.983, P=0.0029) and Log2 VAI (OR 1.690, P=0.0486) had a higher risk of EMS. Subgroup analysis showed stronger associations among women with diabetes (Log2 LAP OR 3.681, P=0.009; Log2 VAI OR 4.849, P=0.041). CONCLUSION Elevated LAP and VAI were independently associated with an increased risk of EMS. LAP and VAI may serve as potential indicators for assessing EMS-related risk, suggesting that visceral obesity and lipid metabolic disturbances might play roles in the pathophysiological process of EMS. These findings underscore the potential of LAP and VAI as non-invasive markers for EMS risk, warranting further validation in clinical settings.
Humans ; Female ; Cross-Sectional Studies ; Endometriosis/metabolism* ; Adult ; Nutrition Surveys ; Intra-Abdominal Fat ; Lipid Accumulation Product ; Middle Aged ; Obesity, Abdominal/complications* ; Adiposity ; Risk Factors ; Logistic Models

Objective To explore the influence of non -urethral suspension surgery in tension -free vaginal tape -obturator technique on patients with stress urinary incontinence.Methods 80 patients with stress urinary incontinence were researched,they were divided randomly into observation group (40 cases) and control group (40 cases).The control group was treated by conventional drug therapy +functional exercise,while the observation group was treated by tension -free vaginal tape -obturator technique on the basis of the control group.The urethral dynamics before and after two months treatment were compared,and the clinical therapeutic effect and recurrence rate were compared.Results After treatment,the voiding time of the observation group was longer than that of the control group[(25.78 ±4.15)s vs.(21.42 ±3.41)s,t =3.465,P <0.05],the mean urinary flow rate was lower than the control group[(6.41 ±1.14)mL/s vs.(9.84 ±1.79)mL/s,t =10.222,P <0.05].The functional urethral length, maximum urethral closure pressure of the observation group were higher than those of the control group[(38.94 ± 8.41)mm vs.(33.47 ±5.38)mm,(36.94 ±9.21)cmH2 O vs.(31.73 ±7.19)cmH2 O,t =3.465,2.820,all P <0.05].The total effective rate of the observation group was higher than that of the control group(72.5% vs.70.0%,χ2 =11.113,P <0.05).After six months of follow -up,the recurrence rate of the observation group was lower than that of the control group(0.0% vs.10.0%,χ2 =4.210,P <0.05 ).Conclusion In patients with stress urinary incontinence,tension -free vaginal tape -obturator technique can significantly improve the urethral dynamics,promote recovery of illness,it is worthy of application and promotion.