Objective To determine relationships between daily activities measured as modified version of Pulmonary Functional status and Dyspnea Questionaire (PFSDQ-M) and functional capacity and symptoms experienced in patients with chronic obstructive pulmonary disease (COPD). Methods Convenience sample of 94 COPD patients with stable condition were assessed by interview with PFSDQ-M Chinese version and modified Medical Research council dyspnea scale (MMRC) respectively. Pulmonary function test (PFT) and 6-minute walking test (6MWT) were undergone on the same day or within one week as interview. PFSDQ-M has three subscales,i.e.,change experienced by patient with activities (CA),dyspnea with activities (DA) and fatigue with activities (FA). Results Scores of CA,DA and FA correlated to 6-minute walking distancer= (-0.37)- (-0.42),FEV_1 r=(-0.27)-(-0.32),FEV_1/FVC r= (-0.27)- (-0.32),dyspnea rated by MMRC (r=0.55-0.60) and BODE index (r=0.35-0.40),respectively (all P<0.01). dyspnea explained 26% of the variance in changes of activities. Conclusions Physical activities moderately changed in patients with stable COPD;Dyspnea is the best predictor of limitation of daily activities.

Objective:To construct a mouse model of dextran sulfate sodium salt (DSS)-induced inflammatory bowel disease and investigate the protective effect of Bifidobacterium animalis BB69 using that model. Methods:Forty C57BL/6J mice were randomly divided into five groups: normal control group (NC group), model group (DSS group), BB69 treatment group (BB group), mesalamine treatment group (MS group), and BB69 combined with mesalamine group (BM). Except for the NC group, the other four groups were given drinking water containing 2.3% DSS for 7 d and the corresponding intervention. The condition of mice in each group was observed.Results:Compared with the mice in the DSS group, those in the BB and MS groups showed significantly reduced disease activity index ( P<0.05), improved colon shortening and edema ( P<0.05), alleviated intestinal mucosal damage and inflammatory cell infiltration, and increased expression of intestinal tight junction protein ( P<0.05). Besides, the differentiation of Treg cells and the expression of anti-inflammatory cytokines were enhanced ( P<0.05). Conclusions:Bifidobacterium animalis BB69 has a significant protective effect on mice with experimental inflammatory bowel disease.