Objective To explore the application and effect of Quality Control Circle (QCC) in improving the overall quality of new nurses.Methods Totally 6 QCC teaching activities were conducted in 6 pilot departments throughout Suqian Hospital of TCM, which involved 31 new nurses as an observation group, while another 46 new nurses from other departments received the traditional one-to-one teaching model as a control group for 6 months. Their comprehensive competency composed of theoretical knowledge, practical skills and on-site reply examined by the steering group from the Nursing Dept. was compared, in addition to their average core competency score measured with Competency Inventory for Registered Nurse (CIRN).Results The 6 QCC activities for the observation group showed better scores, and the new nurses in this group had better theoretical knowledge, practical skills, on-site reply as well as core competency scores than the new nurses in the control group (P<0.01).Conclusions The QCC teaching model can improve new nurses' theoretical learning, practical ability and core competency and contribute to their better comprehensive quality, thus worthy of further promotion in clinical practice.