Objective:To explore the effect of computerized cognitive behavioral therapy on perioperative psychosomatic symptoms in patients with gastric cancer.Methods:Using the convenience sampling method, a total of 76 gastric cancer patients who were scheduled to undergo surgical treatment in Gastrointestinal Department of First Hospital of Shanxi Medical University from September 2021 to March 2022 were selected as the research objects. A total of 38 patients admitted from September to December 2021 were set as test group, while 38 patients admitted from January to March 2022 were set as control group. The control group was given routine nursing measures, while the test group was given psychosomatic intervention program of computerized cognitive behavioral therapy based on routine nursing measures. The effects of the intervention were evaluated using Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Visual Analogue Scale (VAS) and Athens Insomnia Scale (AIS). The first time to get out of bed, first postoperative exhaust time and the postoperative length of hospital stay were compared between the two groups.Results:After intervention, the SAS, SDS and AIS score of the test group was lower than that of the control group, and the difference was statistically significant ( P<0.05). VAS score of the test group was lower than that of the control group at different time points after surgery, and the difference was statistically significant ( P<0.05). The first time to get out of bed, the first time to exhaust gas and the postoperative hospital stay in the test group were shorter than those in the control group, and the differences were statistically significant ( P<0.05) . Conclusions:The implementation of computerized cognitive behavioral therapy can effectively improve perioperative psychosomatic symptoms of gastric cancer patients and the postoperative recovery process.