The target organs of the most common complications in thoracic radiotherapy mainly contain esophagus,lung and cardiovascular system.Studies of influences such as the related physical dose factors and combined chemotherapy and so on,susceptible biomarks,protective factors,become the study focus,which provide the light for clinical prevention and therapy.

OBJECTIVETo evaluate the association of MnSOD single nucleotide polymorphisms (SNPs) with the susceptibility to nasopharyngeal carcinoma (NPC) in Cantonese.

METHODSA total of 105 Cantonese NPC patients and 136 age-matched healthy controls were enrolled in this study. Genotyping of the SNP Ala-9Val of MnSOD gene was performed by PCR and direct sequencing of the PCR products.

RESULTSThe allele frequency of Ala in Cantonese was 19.1%. The frequencies of Val/Val, Val/Ala, and Ala/Ala genotypes were 83.8%, 14.3%, and 1.9% in NPC patients and 80.9%, 16.9%, and 2.2% in healthy individuals, respectively. No significant differences were found in the allele or genotype frequencies between NPC patients and controls. Ala/Val genotype was shown to be significantly less frequent in patients with a positive lymph node status, but the allele Ala was not correlated to lymph node involvement. No significant differences were found in the allele and genotype frequencies in patients with different tumor sizes, metastatic statuses, clinical statuses and histological types.

CONCLUSIONMnSOD Ala-9Val polymorphism can be region- and race-related, and it is not correlated to the genetic susceptibility of NPC in Cantonese.

Adolescent ; Adult ; Aged ; Carcinoma ; Case-Control Studies ; China ; epidemiology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; epidemiology ; genetics ; Polymorphism, Single Nucleotide ; Superoxide Dismutase ; genetics ; Young Adult

The volatile oil of Magnolia liliflora ，as the main active part of the medicinal value ，has rich chemical constituents ， mainly including cineole ，farnesol，α-pinene，β-pinene，terpineol，cadinene，linalool，citronellol，camphor. It has a wide range of pharmacological effects ，mainly anti-inflammatory and anti-allergic effects. Clinically ，it is mainly used to treat acute and chronic rhinitis，allergic rhinitis and sinusitis. This paper summarizes the research reports on the volatile oil of M. liliflora at home and abroad in the past 10 years，compares the chemical constituents of the volatile oil from M. liliflora under different conditions （origin，variety，part and extraction method ），combs its pharmacological effects and clinical application status ，and looks forward to its development prospect ，in order to provide reference for the further development of the medicinal value of the volatile oil from M. liliflora .