OBJECTIVE:To analyze the status quo and tendency of TCM injection in our hospital. METHODS:Consumption sum,DDDs and DDDC of TCM injections in our hospital from 2006 to 2009 were analyzed statistically. RESULTS:The consumption sum of TCM injections increased year by year. The consumption sum of TCM injection was increased by 40.24% in 2007 and 32.66% in 2008 while it was decreased by 1.84% in 2009. The proportions of consumption sum of TCM injection in total consumption sum of drugs in 4 years were 2.59%,3.43%,3.98% and 3.30% respectively,showing yearly increasing trend. CONCLUSION:The application of TCM injection in our hospital shows a reasonable increase. Clinical pharmacists have rational reaction to ADR and adverse events caused by TCM injections.

Objective To explore serum caspase-3 activity in pulmonary tuberculosis patients.Methods 38 tuberculosis pa-tients in Infectious Disease Department in the First Affiliated Hospital of Guangxi Medical University were recruited and the peripheral venous blood was collected in December,2010.Among them,sputum smear-positive patients which were first treated were 13,sputum smear-negative patients which were first treated were 15,10 cases were drug resistance.In addition, 22 unrelated healthy individuals from a routine health survey were enrolled as controls.Spectrophotometry was used to de-tect serum caspase-3 activity in tuberculosis patients,which was absorbancy-A of 4-nitroaniline generated by caspase-3.Re-sults The activity of caspase-3 in sputum smear-positive patients,sputum smear-negative patients,drug resistance patients, and healthy controls were 37.15±5.06,50.38±6.29,45.32±3.32 and 23.89±2.29,respectively.The caspase-3 activity was significantly different from each other (F=10.68,P<0.01).Compared with the healthy controls,the caspase-3 activity in sputum smear-positive patients (q=3.51,P=0.016),sputum smear-negative patients (q=7.5,P<0.001),drug resist-ance patients (q=5.34,P=0.001)was significantly different.There was no statistical difference among sputum smear-posi-tive patients,sputum smear-negative patients and drug resistance pulmonary tuberculosis patients (P>0.05).In the same way,there was no significant difference in male/female ratio[χ2=0.38 (DL=3),P=0.94]and mean age (F=0.82,P=0.49)among the four group.Conclusion Caspase-3 closely associated with the development of tuberculosis occurrence, which might promote apoptosis of cells through the activation of caspase-3 and produce the body immune process of tubercu-losis.