The accumulated evidence indicated atherosclerosis (AS) is associated with a chronic inflammatory reaction. Either by secretion of inflammatory mediator or by modulation of expression of adhesive molecules onvascular surface, vascular endothelial cells play a key role in initiation and amplification of inflammation in artery. The NF ?B transcription factor family is a pleiotropic regulatory of endothelial cells activation and the multiple genes relevant inflammatory cytokines are regulated by NF ?B transcriptional activation in endothelial cells. Selective protection of vascular endothelium and regulation of endothelial inflammation may be rational as the target for anti AS.

To investigate the effect of serum uric acid concentration on prenatal outcome in pregnancy induced hypertension (PIH) patients. Methods:Serum uric acid (UA),creatinine (Cr) and urea nitrogen (BUN) were measured in 248PIH patients. The prenatal prognosis was analyzed. Results: Serum UA concentration was closely related to the degree of PIH. The level of UA in severe PIH patients was significantly higher than in mild and moderate PIH patients ( P ＜ 0.01, P＜ 0.01 ). When UA levels rose,the incidences of intrauterine growth retardation,dead fetus,intrauterine distress and newborn mortality increased significantly. The higher the UA level was, the worse the prenatal prognosis was. Conclusion: In PIH patients,the serum UA level is closely related to the prenatal outcome. It can be used to assess the prenatal prognosis and as an index to terminate gestation appropriately

Objective To assess the relationship between the HLA gene sharing of couples and gestational diabetes mellitus (GDM). Methods Thirty GDM women and their husbands served as study group, 40 normal pregnant women and their husbands were selected as control group. All pregnant women were primipara with single fetus. 5 ml cubital venous blood were taken. Genomic DNA was extracted using phenol chloroform method. HLA-DRB alleles type were determined with PCR-SSP. Results The sharing of HLA-DRB1 between couples in GDM group were 33.33%, significantly higher than that of normal pregnancy(12.50%)(P0.05). Conclusions The sharing of HLA-DRB1 between couples may inerease the risk of GDM, It suggested that placenta- and-fetus unit may play roles in GDM.

Objective To investigate the efficacy of acupuncture combined with doctor-nurse cooperation mode on stroke-associated pneumonia in patients with acute stroke. Methods 67 patients of acute stroke within 1 week in our hospital from March, 2013 to January, 2015 were randomly divided into control group (n=35) and treatment group (n=32). Both groups received neurological routine treatment and systematic rehabilitation training by professional physiotherapists under general nursing mode. The treatment group received acupuncture treatment under doctor-nurse cooperation mode additionally. Incidence of stroke-associated pneumonia, swallow function and aspiration rate were recorded. Results Compared with the control group, the incidence of stroke-associated pneumonia significantly decreased in the treat-ment group after treatment (χ2=4.615, P=0.032). The retention volume of epiglottic vallecula and pyriform sinus (tdilute barium=21.01, tthick barium=19.85), the duration of pharynx period (tdilute barium=17.03, tthick barium=13.68), and the start time of pharynx period (tdilute barium=19.63, tthick barium=17.86) were less in the treatment group than in the control group (P<0.05). In the test of dilute barium, the aspiration rate was lower in the treatment group than in the control group (χ2=4.03, P=0.044), however, there was no significant difference between 2 groups in the test of thick bari-um and solid food (P>0.05). Conclusion Acupuncture combined doctor-nurse cooperation mode may decrease the rates of aspiration and stroke-associated pneumonia in acute stroke patients through improving their swallow function.

Objective To explore the effect of cyclogest and femotroneinthreatened abortion treatment and summerize key points of nursing. Methods Forty-two cases of first trimester threatened abortion women were selected from department of gynecology and obstetrics, which were randomly divided into the control group (n=21) and experiment group (n=21)using random digit table. The control group was given femotrone 40mg intramuscular injection each day while the experiment group was given 90 mg of vaginal progesterone suppository (Cyclogest) each day. Compare the improvement of symptoms, the success rate of pregnancy, changes in serum human chorionic gonadotropin (HCG) and progesterone. Results The improvement of symptoms, curative effects and change of HCG of both groups were no significantly difference. But elevatorconcentration of serum progesterone in femotrone group was higher than that of the cyclogest groupwith statistically difference. Conclusions Although cyclogest cannot appear significantly in increasing serum progesterone levels, it has the same effect as femotrone. Recommendations and notes about the use and side effects of cyclogest and femotrone should be provided for education to alleviate concerns of patients.

Natural medicine chemistry is a comprehensive academics which has strong profession and fulfillment.Traditional teaching mode is very difficult to satisfy a teaching demand.The multi-media teaching carries on audio-visual teaching by sketch,animation,voice,video frequency...etc.to promote students to obtain and keep knowledge.It also plays an important role in organizing and managing teaching information,setting up ideal study environment,raising students’study interest.This text mainly focuses on how the multi-media teaching guide the student studying natural medicine chemistry.

Objective To observe the effect of acupuncture combined with moxibustion on heart rate variability (HRV) in patients with post-stroke depression. Methods 120 patients were divided into control group (n=60) and treatment group (n=60). Both groups took fluoxetine and accepted acupuncture therapy, and the treatment group accepted moxibustion additionally. Hamilton Depression Rating Scale-17 (HAMD-17) and the change of HRV were compared before and after treatment. Results The score of HAMD was lower, and the reductive ratio was higher in the treatment group than in the control group (P<0.05). The standard deviation of the mean of qualified normal sinus interval (SDNN) and standard deviation of sequential five-minute R-R interval means (SDANN) increased in both groups after treatment (P< 0.05), and were higher in the treatment group than in the control group (P<0.05). The root mean square differences of successive R-R intervals (RMSSD) and percentage of differences between adjacent normal sinus intervals greater than 50 ms (PNN50) decreased in both groups after treatment (P<0.05), and were lower in the treatment group than in the control group (P<0.05). The low frequency (LF), high frequency (HF) and LF/HF were higher in both groups after treatment (P<0.05), and were higher in the treatment group than in the control group (P< 0.05). Conclusion Acupuncture combined with moxibustion therapy can better adjust the function of autonomic nerve and reduce depression in patients with post-stroke depression.

Objective To observe the effect of needle warming moxibustion on cognitive dysfunction after stroke. Methods 76 stroke patients with cognitive dysfunction were randomly divided into treatment group (n=38) and control group (n=38). The treatment group received needle warming moxibustion and routine rehabilitation for 4 weeks, while the control group only received routine rehabilitation. They were assessed with Montreal Cognitive Assessment (MoCA) and activities of daily living (ADL) scale before and after treatment. Results The score of MoCA and ADL improved in both groups (P<0.05), and improved more in the treatment group than in the control group (P<0.05) after treatment. Conclusion Needle warming moxibustion could improve cognitive function in patients after stroke and activities of daily living.

Objective To investigate the effectiveness of oxytoein antagonist atosiban in the alternative rescue therapy of preterm labor.MethodsAlternative toeolysis atosiban was given as rescue therapy to 35 women,who had received ritodrine or magnesium sulphate but failed,due to either progression of labour or intolerable adverse events.Atosiban was administered for up to 48 hours.Efficacy and tolerability were assessed based on the proportion of women who did not deliver and did not need alternative toeolytie therapy at 48 hours and 7 days after therapy initiation.The numbers of maternal adverse events and neonatal morbidity were also assessed.ResultsEfficacy and tolerability at 48 hours and 7 days after atosiban nitiation were 77％(27/35)and 60％(21/35).One woman presented drug-related side effects with mild nausea and omiting.Thirty-four women have delivered and one bigemina(28 weeks)is being followed-up.In 34 women,11 delivered before 28 gestational weeks,17 delivered after 28 gestational weeks,3 delivered after 34 weeks and 3 had term delivery.Pregnancies were rolonged by 4 hours to 14+2 weeks.There were nine neonatal deaths,with gestational ages less than 28 weeks at delivery.Conclusion xytocin antagonist atosiban could be given as alternative rescue therapy if therapy with ritodrine or magnesium sulphate fails in the treatment of preterm labor,and it is safe and effective.

Objective To explore the difference in the intensity of brain activation during the recognition of sad facial expression and changes in neuropsychology cognition in patients with a first depressive episode and with recurrent depression.Methods 11 patients with a first major depressive episode,11 patients with recurrent major depression and 11 healthy controls matched in all aspects were scanned to compare the intensity of brain activation in the process of sad and neural facial expression recognition Results Compared with the healthy,first-episode depressed patients showed increased activation in right cuneus(BA18),right fusiform gyrus(BA20),left medial frontal gyrus(BA6),left middle temporal gyrus(BA39),left parahippocampal gyrus(BA30)and decreased activation in right temporal gyrus(BA22),right parahippocampal gyrus(BA27);recurrent depressed patients showed increased activation in right medial frontal gyrus(BA6),right superior temporal gyrus(BA38)but no activation increased.In comparation with the first-episode depressed,the recurrent,showed decreased activation in right middle frontal gyrus(BA6),fight thalamus,right superior temporal gyrus(BA22),right precentral gyras(BA44),right claustrum and increased activation in right parahippocampal gyrus(BA28),right claustrum,right insula(BA13). Conclusion The neural correlates of patients with depression,especially the first-episode depressed for recognition of sad facial expression is different from the healthy with more brain regions involved in the process.There are also differences in the neural basis for recognition of sad facial expression between patients with a first depressive episode and patients with recurrent depression.Performances of brain regions related with emotional recognition de-clined more in the recurrent depressed.