OBJECTIVE:To investigate the effects of simvastatin on neurologic function and prognosis of patients with cere-bral infraction. METHODS:A total of 82 patients with cerebral infarction selected from our hospital during Jan. 2015 to Jul. 2016 were divided into observation group and control group according to random number table,with 41 cases in each group. Control group received routine thrombolytic therapy and Aspirin enteric-coated tablets 100 mg orally,qd. Observation group was additional-ly given Simvastatin tablets 10 mg,qd,on the basis of control group. After 1 month of treatment,prognosis,ADE as well as NI-HSS scores before and after treatment were compared between 2 groups. Multiple factor Logistic regression analysis was conducted for clinical information of patients. RESULTS:The excellent rate of prognosis in observation group was 80.49％,which was signifi-cantly higher than 68.29％,with statistical significance(P<0.05). The incidence of intracranial and extracranial vascular stenosis, brain-heart syndrome and death in observation group were 36.59％,19.51％,0,which were significantly lower than 46.34％, 36.59％,7.32％ of control group,with statistical significance(P<0.05). At admission,there was no statistical significance in NI-HSS scores between 2 groups(P>0.05). After 1 month of treatment,NIHSS scores of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statistical significance(P<0.05). Age >65 years,NI-HSS score <4 points at admission,combined diabetes,non-use of statins were independent risk factors which affected the survival of patients with cerebral infarction(P<0.05). CONCLUSIONS:Simvastatin can significantly improve the neurologic function and prognosis of patients with cerebral infarction,and reduce the incidence of ADE. Non-use of statins is an independent risk factor which affects the survival of patients.

Objective To investigate radiological diagnosis of ossifying fibroma of long bone.Methods The imaging features in 16 patients with ossifying fibroma of long bone confirmed by pathology and surgery were analysed.All 16 patients underwent radiographic examinations,of them,CT was performed in 8 patients,MR was performed in 3 patients.Results In 16 cases,ossifying fibroma was accurately diagnosed by X-ray in 11/16 cases,by CT in 7/8 cases.MR imaging was commonly superior to CT in showing the relationship between the lesions and isthmus.Conclusion CT scan can improve the diagnosis of ossifying fibroma of long bone,and is better in demonstrating the extension of fesions than X-ray plain film,which is important for guiding clinical treatment,and MRI can be used as an important supplemental method.

Objective To evaluate the efficacy and safety of endoscopic mucosal resection (EMR) for rectal carcinoid tumors. Methods From January 2006 to January 2009, EMR was performed in 28 patients with rectal carcinoids, who were followed up to evaluate the therapeutic effect and safety. Results Tumor diameters varied from 0.4 cm to 1. 2 cm (mean 0.7± 0. 2 cm). Negative resection margin was a-chieved in 26 cases (92. 9% ), tumor margin within 0. 1 cm of resection margin in 1 (7. 1% ) , and two margins coincided in 1 patient (7. 1% ). Hemostasis was performed with metal clips in 14 patients (50% ) and argon plasma coagulation (APC) in 9 (32. 1% ). Except for rectal bleeding in 1 patient (3. 6% ) , no other complications were observed. There was no recurrence in any patients during a follow-up of 6-36 months. Conclusion EMR is a useful and safe method for treatment of small rectal carcinoid tumor which does not cross submucosal layer.

Aim To investigate the effects of the novel compound C333H on reduce blood glucose and lipid in vivo.Methods Normal KM mice,hyperlipidaemia mice and type 2 diabetic mice by intragastric gavage were used and total RNA from liver,adipose and skeletal muscle were isolated for RT-PCR.Results C333H reduced blood lipid level and improved glucose metabolism.In addition,C333H increased expressions of LPL,aP2 and GluT4 at transcriptional level.Conclusion C333H is a novel PPAR?/? agonist,signivicantly reducing blood lipid and glucose,which had potential as a therapy for type 2 diabetes.

The peroxisome prolifrator-activated receptors(PPARs)? and ? constitute a subfamily of nuclear receptors. PPAR? has been shown to be activat ed by the hypolipidemic drugs of the fibrate class; While the antidiabetic TZD a re synthetic ligands for PPAR?. Upon binding and activation by their ligands, t hey regulate the transcription of numerous genes involving lipid metabolism and insulin resistance. The research indicated that PPAR? also plays a key role in lipid metabolism. PPARs therefore constitute interesting targets for the develop ment of single and dual agonists useful in the treatment of obesity and type 2 d iabetes.

Objective: To investigate the effects of calcitonin on human breast cancer cell line T47D. Methods: The inhibition rates of salmon calcitonin (sCT) on T47D cells were measured by MTT methods. Then telomerase activity of T47D cells was detected using PCR ELISA methods. Cell apoptosis was observed by transmission electron microscope (TEM). Animal models in vivo were constructed by implanting T47D cells subcutaneously into nude mice. After injection of sCT for 30 days, tumor diameters were measured. The structure of lumbar 3 were separated and compared by a scanning electron microscope (SEM). Results: The inhibitory effects of sCT on T47D cells was observed by MTT method. The PCR ELISA method discovered that sCT could decrease the telomerase activity of T47D cells. TEM found cell apoptosis induced by sCT. Tumor diameters in sCT treatment group showed no statistical difference compared with the control group. SEM of lumbar 3 discovered that sCT could strengthen the bone structure of nude mice. Conclusions: The decrease of telomerase activity and induction of apoptosis are new mechanisms of sCT inhibition on T47D cells. The tumor inhibition in vivo was not observed. This may be attributed to the complicated endocrine response in vivo . sCT is still effective in strengthening the bone structure of those nude mice without osteoporosis.

Objectiye To evaluate the therapeutic efficacy and safety of (endoscopic sphincterotomy, EST) plus balloon dilation for difficult bile duct stones. Methods Patients with difficult common bile duct stones on endoscopic retrograde cholangiopancreatography (ERCP) from March 2008 to December 2009 were randomly divided into 2 groups to receive EST or EST plus balloon dilation ( EST + EPBD), respectively. The success rate of complete stone removal, number of endoscopic sessions, the rate of using mechanical lithotripsy and the complication rate related to the procedure were compared between the 2 groups. Results Compared with EST alone, EST plus balloon dilation resulted in similar outcomes in terms of overall successful stone removal rate (2/62 vs. 2/61 ) and early complication rate (4/62 vs. 6/61, P ＞0. 05). However,EST group needed more sessions ( EST 15/46 vs. EST + EPBD 5/57, P ＜0. 05) and use of mechanical lithotripsy to achieve complete removal of stones ( EST 12/61 vs. EST + EPBD 4/61, P ＜0. 05 ). Conclusion EST plus balloon dilation is as safe and effective as, but more convenient than EST, for endoscopic removal of common bile duct stones.

Objective To evaluate the efficacy and safety of fluoroscopy guided frequency-doubled double-pulsed laser lithotripsy for removing difficult bile duct stones. Methods From March 2008 to December 2009, patients with difficult bile duct stones were divided into cholangioscopy guided group ( n = 21 )and fluoroscopy guided group ( n = 19) to receive corresponding treatments. The success rate of complete stone removal and the complication rate related to the procedure were compared between the two groups.Results There are no significant differences between 2 groups in regarding of either success rate of complete stone removal ( 19/21, 90. 5% in cholangioscopy guided group vs. 17/19, 89. 5% in fluoroscopy guided group, P ＞0. 05 ) or rate of procedure related complication (4/21, 19. 0% in cholangioscopy guided group vs. 3/19, 15. 8% in fluoroscopic guided group, P = 0. 559 ). Conclusion Frequency-doubled doublepulsed laser lithotripsy guided by cholangioscopy or fluoroscopy are both safe and effective.

OBJECTIVE To establish RAPD typing method for Enterobacter aerogenes,and apply RAPD to study molecular epidemiology of E.aerogenes in a neonatal unit.METHODS Five E.aerogenes strains were isolated from four patients in the same neonatal unit at the same time.These strains were typed by RAPD technique.Antibiotic susceptibility was determined by MIC to evaluate drug-resistance.RESULTS Two strains belonging to a unique RAPD-typed ones were epidemiologically related strains.These strains isolated from two patients who hospitalized in the same neonatal unit for four and ten days,respectively.Five E.aerogenes strains were resistant to aminoglycosides,piperacillin and the third-generation cephalosporins in varying degree.CONCLUSIONS RAPD technique is a very easy and reliable molecular tool in the study of E.aerogenes epidemiology.Antibiotic resistance of E.aerogenes is probably related with the history of using antibiotics.

Objective To investigate waist-to-height ratio(WHtR) and body mass index(BMI) for the screening and prediction of metabolic syndrome and explore the best indicator for predicting metabolic syndrome(MS) in the elderly.Methods A cluster random sampling method was used.5 010 cases aged 60-70 years old of Renqiu permanent residents were selected as a screening subjects.The face to face health questionnaires,anthropometric measurements,and laboratory testing were conducted.Receiver operatiug characteristic (ROC) was used to analyze and calculate the area under the curve(AUC).Results WHtR predict the best point of tangency of MS were 0.54 (men),0.5 5 (women),BMI predict the best point of tangency of MS were 25.25kg/m2 (men),2 5.0 5 kg/m2 (women).In the same gender,the contrast of WHtR and BMI in predicts MS area under the curve,WHtR area under the curve of the larger,WHtR was higher than BMI,WHtR was a better indicator in predicted of MS.Conclusion WHtR and BMI have important roles in the screening and prediction of MS,and WHtR seems to be the best parameter in the screening and prediction of MS in the elderly.