? Objective? To explore the effects of group intervention model based on self-disclosure theory on burden of main caregivers among stroke patients. Methods? From January 2015 to January 2016, we selected 60 main caregivers of stroke inpatients from Department of Neurology and Neurological Rehabilitation in Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine as subjects by convenience sampling. All of the patients were divided into observation group and control group according to the admission time, 30 cases in each group. Observation group received group intervention model based on self-disclosure theory. Control group carried out routine nursing instruction. Burden and life quality were evaluated with the Zarit Caregiver Burden Interview (ZBI) and World Health Organzation Quality of Life Assessment Instrument Brief Version (WHOQOL-BREF) before and five weeks after intervention. Results? There were statistical differences in the total score of ZBI and the scores of two dimensions (personal burden and responsibility burden) of main caregivers of stroke patients in observation group before and after intervention (P＜0.05). There was no statistical difference in the total score of ZBI and the scores of two dimensions (personal burden and responsibility burden) of main caregivers of stroke patients in control group before and after intervention (P＞0.05). The differences in the total score of ZBI and the scores of two dimensions of main caregivers of stroke patients were statistical between two groups after intervention (P＜0.05). There were statistical differences in the total score of WHOQOL-BREF and the scores of two dimensions (psychology and social relations) in observation group before and after intervention (P＜0.05). There were statistical differences in the total score of WHOQOL-BREF and the scores of social relations in control group before and after intervention (P＜ 0.05). There were statistical differences in the total score and scores of physiology, psychology and social relations between two groups before and after intervention (P＜ 0.05). Conclusions? The application of group intervention model based on self-disclosure theory in main caregivers of stroke patients can effectively reduce caregivers burden and improve their quality of life.