Objective To observe the efficacy of compound Kali Ziran tincture combined with narrow-spectrum ultraviolet B in the treatment of vitiligo.Methods All patients were recruited into a treatment group and a control group.The patients in the treatment group were exposed to NB-UVB after treated with compound Kali Ziran tincture for 30 minutes.The patients in the control group were only exposed to NB-UVB for treatment.Results The total effective rate of the treatment group and the control group was 70% and 46.63% separately.Conclusion Compound Kali Ziran tincture combined with narrow-spectrum ultraviolet B has good effect in treating vitiligo.

OBJECTIVE:To study the improving effects of argatroban on the brain damage of model rats with cerebral hemor-rhage. METHODS:50 SD rats were randomly divided into normal control group(equivalent normal saline),model group(equiva-lent normal saline),argatroban high,medium and low dose groups (0.75,1.5,3 mg/kg). All groups,except for normal control group,were reproduced models with cerebral hemorrhage,and the rats in each group were treated by corresponding drugs after 30 min,ip,once a day. The rats were executed after continuous administration for 3 days. The data was detected,including the con-tents of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),activity of cysteine-containing aspartic protease 3(Caspase-3), expressions of Bcl-2,Bax,matrix metalloproteinase-2(MMP-2)and MMP-9,and the phosphorylations of nuclear factor κB(NF-κB) p65 and IκBα. RESULTS:Compared with the normal control group,the contents of TNF-α and IL-1β,the activity of Cas-pase-3,the expressions of MMP-2,MMP-9 and Bax proteins were increased;the expression of Bcl-2 was decreased;and phos-phorylations of NF- κB p65 and IκBα in model group were increased,with significant differences(P<0.01). Compared with the model group,the contents of TNF-α and IL-1β,the activity of Caspase-3,the expressions of MMP-2,MMP-9 and Bax were de-creased;the expression of Bcl-2 was increased;and phosphorylations of NF-κB p65 and IκBα in argatroban low,medium and high dose groups were decreased,with significant differences (P<0.01 or P<0.05). And it was positively correlated with the dose. CONCLUSIONS:Argatroban has dose-dependent inhibition effects on the inflammatory cytokine secretion and apoptosis of brain tissue of model rats with brain hemorrhage,and the mechanism may be related to NF-κB signaling pathway.

Objective: To reclarify the natural change trend of several hormones with age in Chinese population. Methods: A cross-sectional survey was performed including 5 935 healthy individuals (2 286 males and 3 649 females) in the final statistical analysis. All participants received questionnaire survey, anthropometric index and laboratory tests including sex-related hormones, insulin, thyroid hormones, and 25-hydroxyvitamin D [25(OH)D]. Kruskal-Wallis test or One-way ANOVA analysis was used to compare hormone levels in different age groups. Spearman analysis was used to explore the correlation between age and hormone levels. Results: (1) Follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations increased with age from 40 years in both males and females, and stabilized at high levels after the age of 60 in females and 80 in males. Estradiol level in females started to decrease since 40 years old, then stabilized around 70 years. Sex hormone binding globulin level increased significantly with age in males, but decreased in postmenopausal females. (2) Fasting serum insulin gradually decreased with age in males until 60 years, but without obvious change in females. Fasting plasma glucose and HbA_1C increased with age in both males and females. (3) Thyroid stimulating hormone (TSH) increased slowly with age in both males and females. (4) 25(OH)D increased with age in both males and females overall, especially more obvious in males. (5) During 41-60 years, FSH and LH levels in menopausal females were much higher than those in premenopausal females, while estradiol level in menopausal females was much lower. Compared with premenopausal females aged 41-50 years, estradiol level in premenopausal females was much lower in 51-60 years. Conclusion The levels of several important hormones are related with age, revealing a natural change trend as aging in Chinese population. (Chin J Endocrinol Metab, 2018, 34: 555-562)

Objective:A structural equation model of the influencing factors on caregiver preparedness at discharge of patients with chronic heart failure was constructed based on the individual and family self-management theory, and the main paths influencing caregiver preparedness were explored.Methods:This study was a cross-sectional survey. A total of 345 caregivers of patients with chronic heart failure who were hospitalized in the Fourth Affiliated Hospital of China Medical University from October 2020 to August 2021 were selected as research objects by convenience sampling method, and they were investigated by Caregiver Preparedness Scale, Family APGAR Index, Herth Hope Index, Social Support-Rating Scale, Simplified Coping Style Questionnaire. The influencing factors on caregiver preparedness at discharge of patients with chronic heart failure were analyzed.Results:The total score of Caregiver Preparedness Scale, Family APGAR Index, Herth Hope Index, Social Support-Rating Scale, and Positive and Negative Coping Subscale of Simplified Coping Style Questionnaire in patients with chronic heart failure was (20.79 ± 4.92), (8.05 ± 1.43), (35.34 ± 4.47), (43.89 ± 6.56), (24.38 ± 5.21), (11.21 ± 4.26) points. Caregiver preparedness in patients with chronic heart failure was positively correlated with family function, hope, positive coping and social support ( r values were 0.213-0.383, all P<0.01), and negatively correlated with negative coping ( r=-0.546, P<0.01). Family function and social support in patients with chronic heart failure could directly or indirectly affect caregiver preparedness (total effect value: 0.380, 0.212), hope and negative coping directly affected caregiver preparedness (total effect value: 0.200, -0.433), and could account for 39% of the total variation in caregiver preparedness. Conclusions:Caregiver preparedness of patients with chronic heart failure needs further improvement. The effective ways to improve caregiver preparedness are to pay attention to family function, improve hope level, increase social support and reduce negative coping.

Motabolic bariatric surgery is a fast and effective method for the treatment of obesity and obesity-associated diseases. In order to maintain weight loss and prevent complications, self-management of bariatric and metabolic surgery patients undergoing metabolic bariatric surgery is very important. This paper summarizes the research status, assessment tools and influencing factors of self-management of patients undergoing metabolic bariatric surgery. This paper also puts forward the problems to be solved in current research and practice, aiming to provide a reference for future research and improving the self-management ability of patients undergoing metabolic bariatric surgery.

Magnetic working environment can improve job satisfaction and nursing quality of nurses. Therefore, this article summarizes the concept, development history, core connotation and measurement tools of magnetic hospitals, and discusses related factors that affect the magnetic level of hospitals, aiming to understand the current situation of magnetic hospitals in China and provide reference basis for improving the magnetic level of domestic hospitals, nurse retention rate and nursing quality through the intervention of influencing factors.

The delay of diabetic foot not only brings painful experience to patients, but also increases the care time and caregiver burden, which seriously affects quality of life of patients and caregivers. This article summarized the definition, research tools, current situation, influencing factors, positive feelings of caregivers and intervention measures of caregivers for diabetic foot patients, aiming to provide a theoretical basis for adoption of targeted intervention measures.

Metabolic bariatric surgery (MBS) is the most effective treatment for severe obesity. In order to achieve and maintain a good weight loss effect after MBS and prevent short-term and long-term postoperative complications, postoperative diet and nutrition management is very necessary. This article summarizes the importance of diet and nutrition management, management status, intervention status, and diet management tools for obese patients after MBS, and puts forward the problems to be solved in my country's current diet and nutrition management, so as to provide a reference for future research on diet and nutrition management after MBS.

Body image is a common concept in the field of psychology and an important indicator for evaluating the quality of life of patients after bariatric and metabolic surgery. This paper reviews the concept of body image, the measurement tools, influencing factors and the intervention of the body image after bariatric and metabolic surgery, so as to provide a reference for domestic research on the body image of patients after bariatric and metabolic surgery.

This paper mainly introduced the current status of quality of life among patients after bariatric and metabolic surgery at home and abroad including different assessment tools,changes and influencing factors of quality of life after surgery so as to provide a reference for medical staff of China to improve the quality of life of patients after bariatric and metabolic surgery and develop a specific assessment tool.