To observe the clinical efficacy of nicorandil for treating the patient with cardiac syndrome X (CSX) and its impact on vascular endothelial function. Methods: A total of 140 CSX patients were randomly divided into 2 groups: Control group, the patients received conventional anti-angina therapy and Nicorandil group, based on conventional anti-angina therapy, the patients received additional oral nicorandil treatment. n=70 in each group. All patients received resting emission computed tomography (ECT) and treadmill exercise ECG stress test (TET). Blood levels of endothelin (ET-1), high-sensitivity C-reactive protein (hs-CRP) and nitric oxide (NO) were examined before and 3 months after treatment. Results: Compared with pre-treatment condition, the attack frequency of angina pectoris and positive rate of ECT were decreased after treatment in both groups, P<0.05; in Nicorandil group, the suspicious positive rate and positive rate of TET were reduced after treatment, P<0.05. Compared with Control group, Nicorandil group had the much lower suspicious positive rate and positive rate of TET after treatment, P<0.05. Blood tests indicated that compared with pre-treatment condition, ET-1 and hs-CRP were decreased, NO was increased after treatment in both groups, all P<0.05; blood levels of ET-1, hs-CRP and NO were different between 2 groups after treatment, all P<0.05. Conclusion: Nicorandil could inhibit inflammatory factors, elevate endothelial function and therefore improve micro vascular angina symptoms, increase exercise tolerance obviously.

Objective To explore the impact of continuing nursing for type 2 diabetes mellitus.Methods The date of 200 diabetic patients was retrospectively analyzed in our hospital,and were divided into two groups.Control group was given common nursing and observation group was given continuing nursing.Self-management ability and SF-36 one day before discharge and 6 months after discharge were compared.Results One day after discharge,Self-management ability of observation group and control group had no significant difference (P ＞ 0.05);After 6 months of discharge,Self-management ability of observation group was obviously higher than control group (P ＜ 0.05).One day after discharge,life quality of the two groups had no significant difference (P ＞ 0.05);After 6 months of discharge,life quality of observation group was better than control group (P ＜ 0.05).Conclusion Continuing nursing can improve self-management skills,prevent complication occurrence,and improve life quality.

Objective To explore the impact of continuing nursing for type 2 diabetes mellitus.Methods The date of 200 diabetic patients was retrospectively analyzed in our hospital,and were divided into two groups.Control group was given common nursing and observation group was given continuing nursing.Self-management ability and SF-36 one day before discharge and 6 months after discharge were compared.Results One day after discharge,Self-management ability of observation group and control group had no significant difference (P ＞ 0.05);After 6 months of discharge,Self-management ability of observation group was obviously higher than control group (P ＜ 0.05).One day after discharge,life quality of the two groups had no significant difference (P ＞ 0.05);After 6 months of discharge,life quality of observation group was better than control group (P ＜ 0.05).Conclusion Continuing nursing can improve self-management skills,prevent complication occurrence,and improve life quality.

Objective To explore the features of frontotemporal lobes'resting-state functional connectivity(rsFC)in preschool children with autism spectrum disorders(ASD)based on functional near-infrared spectroscopy(fNIRS)and to explore the possible neurological markers for early identification of ASD.Methods Sixty-three preschool ASD children and 72 typical development(TD)children were enrolled.Selected bilateral dorsolateral prefrontal cortex(DLPFC),bilateral premotor cortex(PMC),and bilateral temporal lobe(TL)cortex as the regions of interest(ROI).Changes of Oxyhemoglobin in the 6 ROIs in resting-state were measured by using functional near-infrared spectroscopy(fNIRS).Compared the frontotemporal rsFC strength and calculate the laterality index(LI)between two groups.Results Compared with the TD group,rsFC strength was significantly lower in the ASD group(P<0.05),and the differences existed mainly within the left ROIs(0.21±0.11 vs.0.32±0.18),right ROIs(0.16±0.16 vs.0.30±0.14),bilateral DLPFCs(0.20±0.14 vs.0.39±0.17;0.15±0.13 vs.0.36±0.13),bilateral TLs(0.15±0.14 vs.0.28±0.17;0.14±0.15 vs.0.31±0.17),and between the 10 groups of ROIs-ROIs(including right DLPFC-left DLPFC,right DLPFC-right PMC,right DLPFC-left PMC,right DLPFC-right TL,right DLPFC-left TL,left DLPFC-right PMC,left DLPFC-left PMC,left DLPFC-right TL,left DLPFC-left TL,right TL-left TL).There were a significant differences in the rsFC's laterality index of DLPFC and whole-brain between the two groups(t=2.002,P=0.047;t=3.003,P=0.003),and the ASD group showed left-lateralized connectivity.Conclusion Frontotemporal lobe's resting-state functional connectivity is abnormal in preschool children with ASD,characterized by low short-range functional connectivity of bilateral DLPFCs and TLs,low long-range functional connectivity associated with DLPFCs,and left-lateralized connectivity.